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PDE1B Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Special Promotion Catalog #: MBS127946
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The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE1 subfamily. Members of the PDE1 family are calmodulin-dependent PDEs that are stimulated by a calcium-calmodulin complex. This PDE has dual-specificity… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
PDE1B, Polyclonal Antibody
Full Product Name
PDE1B Polyclonal Antibody
Product Gene Name
anti-PDE1B antibody
Product Synonym Names
PDE1B1; PDES1B
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Purity/Purification
Affinity Purification
Concentration
1mg/ml (lot specific)
Preparation and Storage
Store at -20 degree C (regular) or -80 degree C (long term). Avoid freeze / thaw cycles.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Molecular Weight
536
OMIM
171891
3D Structure
ModBase 3D Structure for Q01064
Species
Human
Immunogen
Recombinant protein of human PDE1B
Calculated Molecular Weight
61kDa

Product Categories/Family for anti-PDE1B antibody

Polyclonal
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-PDE1B antibody
Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
Application Notes for anti-PDE1B antibody
WB: 1:500 - 1:2000
IHC: 1:50 - 1:200
IF: 1:50 - 1:200

Western Blot (WB) of anti-PDE1B antibody

Western blot analysis of extracts of various cell lines, using PDE1B antibody at 1:500 dilution.
Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (MBS128200) at 1:10000 dilution.
Lysates/proteins: 25ug per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Rabbit Anti-PDE1B Polyclonal Antibody – Cat# MBS127946

Immunohistochemistry (IHC) of anti-PDE1B antibody

Immunohistochemistry of paraffin-embedded rat brain using PDE1B antibody at dilution of 1:100 (40x lens).
Rabbit Anti-PDE1B Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS127946

Immunofluorescence (IF) of anti-PDE1B antibody

Immunofluorescence analysis of U2OS cells using PDE1B antibody. Blue: DAPI for nuclear staining.
Rabbit Anti-PDE1B Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS127946

Other Notes

Small volumes of anti-PDE1B antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PDE1B purchase

MBS127946 is an antibody targeting PDE1B. Also known as PDE1B Polyclonal Antibody. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for PDE1B. It may not necessarily be applicable to this product.

NCBI GI #
3183514
NCBI GeneID
5153
NCBI Accession #
Q01064.2
UniProt Primary Accession #
Q01064
UniProt Secondary Accession #
Q92825; Q96KP3
UniProt Related Accession #
Q01064
NCBI Official Full Name
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B
NCBI Official Synonym Full Names
phosphodiesterase 1B, calmodulin-dependent
NCBI Official Symbol
PDE1B
NCBI Official Synonym Symbols
PDE1B1; PDES1B
UniProt Protein Name
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B
UniProt Synonym Protein Names
63 kDa Cam-PDE
UniProt Gene Name
PDE1B
UniProt Synonym Gene Names
PDE1B1; PDES1B; Cam-PDE 1B
UniProt Entry Name
PDE1B_HUMAN
NCBI Protein Information
calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B; cam-PDE 1B; 63 kDa Cam-PDE; calmodulin-stimulated phosphodiesterase PDE1B1; calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase; presumed 63kDa form of the type 1 cyclic nucleotide phosphodiesterase family known as PDE1B

UniProt Comments for PDE1B

PDE1B: Cyclic nucleotide phosphodiesterase with a dual- specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has a preference for cGMP as a substrate. Belongs to the cyclic nucleotide phosphodiesterase family. PDE1 subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.1.4.17; Nucleotide Metabolism - purine; Phosphodiesterase; Apoptosis

Chromosomal Location of Human Ortholog: 12q13

Cellular Component: cell soma; cytosol

Molecular Function: calmodulin binding; 3',5'-cyclic-AMP phosphodiesterase activity; calmodulin-dependent cyclic-nucleotide phosphodiesterase activity; calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity; metal ion binding

Biological Process: epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; nerve growth factor receptor signaling pathway; monocyte differentiation; apoptosis; regulation of neurotransmitter levels; response to amphetamine; cAMP catabolic process; regulation of dopamine metabolic process; locomotory behavior; signal transduction; phospholipase C activation; innate immune response; visual learning; cGMP catabolic process; blood coagulation; serotonin metabolic process
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Research Articles on PDE1B

1. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-PDE1B antibody

 Products by Pathway  Pathway Diagram
 Ca-dependent Events Pathway antibodies  Ca-dependent Events Pathway Diagram
 CaM Pathway antibodies  CaM Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Calmodulin Induced Events Pathway antibodies  Calmodulin Induced Events Pathway Diagram
 Cam-PDE 1 Activation Pathway antibodies  Cam-PDE 1 Activation Pathway Diagram
 DAG And IP3 Signaling Pathway antibodies  DAG And IP3 Signaling Pathway Diagram
 DAP12 Interactions Pathway antibodies  DAP12 Interactions Pathway Diagram
 DAP12 Signaling Pathway antibodies  DAP12 Signaling Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram

Diseases associated with anti-PDE1B antibody

 Disease Name  Pubmed Publications
 Disease Models, Animal Antibodies  >5 publications with PDE1B and Disease Models, Animal
 Nervous System Diseases Antibodies  >5 publications with PDE1B and Nervous System Diseases
 Brain Diseases Antibodies  >3 publications with PDE1B and Brain Diseases
 Cardiovascular Diseases Antibodies  >2 publications with PDE1B and Cardiovascular Diseases
 Cognition Disorders Antibodies  >2 publications with PDE1B and Cognition Disorders
 Neoplasms, Experimental Antibodies  >1 publications with PDE1B and Neoplasms, Experimental
 Fatty Liver Antibodies  >1 publications with PDE1B and Fatty Liver
 Fever Antibodies  >1 publications with PDE1B and Fever
 Carcinoma, Hepatocellular Antibodies  >1 publications with PDE1B and Carcinoma, Hepatocellular

Organs/Tissues associated with anti-PDE1B antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >17 publications with PDE1B and Brain
 Muscle Antibodies  >12 publications with PDE1B and Muscle
 Eye Antibodies  >4 publications with PDE1B and Eye
 Testis Antibodies  >3 publications with PDE1B and Testis
 Spleen Antibodies  >3 publications with PDE1B and Spleen
 Lung Antibodies  >3 publications with PDE1B and Lung
 Kidney Antibodies  >2 publications with PDE1B and Kidney
 Adipose Tissue Antibodies  >2 publications with PDE1B and Adipose Tissue
 Embryonic Tissue Antibodies  >2 publications with PDE1B and Embryonic Tissue
 Pancreas Antibodies  >1 publications with PDE1B and Pancreas
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