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SCN4B Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Special Promotion Catalog #: MBS127969
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MBS127969 is an antibody targeting SCN4B. Also known as SCN4B Polyclonal Antibody. Reactive in Human, Mouse, Rat. Host: Rabbit. More details

$225 / 0.02 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
SCN4B, Polyclonal Antibody
Full Product Name
SCN4B Polyclonal Antibody
Product Gene Name
anti-SCN4B antibody
Product Synonym Names
Gm1471
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Purity/Purification
Affinity Purification
Concentration
1mg/ml (lot specific)
Preparation and Storage
Store at -20 degree C (regular) or -80 degree C (long term). Avoid freeze / thaw cycles.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Molecular Weight
228
3D Structure
ModBase 3D Structure for Q7M729
Species
Mouse
Immunogen
Recombinant protein of mouse SCN4B
Calculated Molecular Weight
25kDa

Product Categories/Family for anti-SCN4B antibody

Polyclonal
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-SCN4B antibody
Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-SCN4B antibody
WB: 1:500 - 1:2000
IHC: 1:50 - 1:200

Western Blot (WB) of anti-SCN4B antibody

Western blot analysis of extracts of various cell lines, using SCN4B antibody at 1:1000 dilution.
Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (MBS128200) at 1:10000 dilution.
Lysates/proteins: 25ug per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Detection: ECL Basic Kit.
Exposure time: 90s.
Rabbit Anti-SCN4B Polyclonal Antibody – Cat# MBS127969

Other Notes

Small volumes of anti-SCN4B antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for SCN4B. It may not necessarily be applicable to this product.

NCBI GI #
57012678
NCBI GeneID
399548
NCBI Accession #
Q7M729.1
UniProt Primary Accession #
Q7M729
UniProt Related Accession #
Q7M729
NCBI Official Full Name
Sodium channel subunit beta-4
NCBI Official Synonym Full Names
sodium channel, type IV, beta
NCBI Official Symbol
Scn4b
NCBI Official Synonym Symbols
Gm1471
UniProt Protein Name
Sodium channel subunit beta-4
Protein Family
Sodium channel
UniProt Gene Name
Scn4b
UniProt Synonym Gene Names
Gm1471
UniProt Entry Name
SCN4B_MOUSE
NCBI Protein Information
sodium channel subunit beta-4; sodium channel beta 4 subunit; sodium channel accessory subunit; sodium channel, type IV, beta polypeptide; voltage gated sodium channel beta 4 subunit

UniProt Comments for SCN4B

SCN4B: Modulates channel gating kinetics. Causes negative shifts in the voltage dependence of activation of certain alpha sodium channels, but does not affect the voltage dependence of inactivation. Defects in SCN4B are the cause of long QT syndrome type 10 (LQT10). Long QT syndromes are heart disorders characterized by a prolonged QT interval on the ECG and polymorphic ventricular arrhythmias. They cause syncope and sudden death in response to excercise or emotional stress. They can present with a sentinel event of sudden cardiac death in infancy. Belongs to the sodium channel auxiliary subunit SCN4B (TC 8.A.17) family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Cellular Component: voltage-gated sodium channel complex; membrane; integral to membrane; plasma membrane; intrinsic to plasma membrane

Molecular Function: sodium channel regulator activity; voltage-gated sodium channel activity; voltage-gated ion channel activity; sodium channel activity

Biological Process: transport; sodium ion transport; ion transport; cardiac muscle contraction
Show more

Research Articles on SCN4B

1. NaVbeta4 plays a blocking role that indicates the relative importance of different residues in inducing open-channel block.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-SCN4B antibody

 Products by Pathway  Pathway Diagram
 Adrenergic Signaling In Cardiomyocytes Pathway antibodies  Adrenergic Signaling In Cardiomyocytes Pathway Diagram
 Adrenergic Signaling In Cardiomyocytes Pathway antibodies  Adrenergic Signaling In Cardiomyocytes Pathway Diagram

Diseases associated with anti-SCN4B antibody

 Disease Name  Pubmed Publications
 Heart Diseases Antibodies  >15 publications with SCN4B and Heart Diseases
 Congenital Abnormalities Antibodies  >7 publications with SCN4B and Congenital Abnormalities
 Heart Defects, Congenital Antibodies  >7 publications with SCN4B and Heart Defects, Congenital
 Long Qt Syndrome 10 Antibodies  >2 publications with SCN4B and Long Qt Syndrome 10
 Abnormalities, Drug-Induced Antibodies  >1 publications with SCN4B and Abnormalities, Drug-Induced
 Nerve Degeneration Antibodies  >1 publications with SCN4B and Nerve Degeneration
 Neurobehavioral Manifestations Antibodies  >1 publications with SCN4B and Neurobehavioral Manifestations
 Fibrosis Antibodies  >1 publications with SCN4B and Fibrosis
 Inflammation Antibodies  >1 publications with SCN4B and Inflammation

Organs/Tissues associated with anti-SCN4B antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >19 publications with SCN4B and Brain
 Muscle Antibodies  >6 publications with SCN4B and Muscle
 Kidney Antibodies  >3 publications with SCN4B and Kidney
 Spinal Cord Antibodies  >2 publications with SCN4B and Spinal Cord
 Eye Antibodies  >1 publications with SCN4B and Eye
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