UNG Antibody – Rabbit Polyclonal

When misincorporation or cytosine deamination positions the RNA nucleotide uracil into DNA, uracilDNA gycosylase (UDG) excises the uracil via a repair enzymatic pathway. This is done by cleaving the NC1' gylcosylic bond between the base and deoxyribose, in both single and doublestranded DNA. While initiating the first steps of DNA repair, UDG undergoes a conformational change from the "open" unbound state to the "closed" DNAbound state, creating a catalytic center. The bound UDG effectively flips the uridine nucleotide into the catalyic center and cleaves the glycosylic bond to excise the uracil. The opentoclosed conformation change is centered on a B zipper in the UDG. UDG alters the orientation electron orbitals to favor electron transpositions, thus taking advantage of conformational strain to catapult the cleavage of the gylcosylic bond. Two isoforms of UDG, UDG1 and UDG1A, have been characterized. The UDG1 isoform localizes to the mitochondria. UDG1A is a processed isoform containing a unique 44 residue aminoterminus which localizes this isoform to the nucleus

Small volumes of anti-UNG antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS128010 is an antibody targeting UNG. Also known as UNG Polyclonal Antibody. Reactive in Human, mouse, rat. Host: Rabbit.