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Leucine-Rich PPR Motif-Containing Protein, Mitochondrial (LRPPRC) Mouse Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1281129

This gene encodes a protein that is leucine-rich and is thought to play a role in regulating the interaction of the cytoskeleton with a variety of cellular processes. Mutations in this gene are associated with the French-Canadian type of Leigh syndrome.… More details

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Product Overview

Online Datasheet in PDF
Product Name
Leucine-rich PPR motif-containing protein, mitochondrial (Lrpprc), Recombinant Protein
Full Product Name
Recombinant Mouse Leucine-rich PPR motif-containing protein, mitochondrial (Lrpprc) , partial
Product Gene Name
Lrpprc recombinant protein
Product Synonym Gene Name
Lrpprc
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Molecular Weight
156,615 Da
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
3D Structure
ModBase 3D Structure for Q6PB66
Species
Mouse
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of Lrpprc recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Lrpprc purchase

MBS1281129 is a recombinant protein targeting Lrpprc. Also known as Recombinant Mouse Leucine-rich PPR motif-containing protein, mitochondrial (Lrpprc) , partial. Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for Lrpprc. It may not necessarily be applicable to this product.

NCBI GI #
134031976
NCBI GeneID
72416
NCBI Accession #
NP_082509.2
UniProt Primary Accession #
Q6PB66
UniProt Secondary Accession #
Q8K4V0; Q9CRX4
UniProt Related Accession #
Q6PB66
GenBank Nucleotide #
NM_028233.2
NCBI Official Full Name
leucine-rich PPR motif-containing protein, mitochondrial
NCBI Official Synonym Full Names
leucine-rich PPR-motif containing
NCBI Official Symbol
Lrpprc
NCBI Official Synonym Symbols
Lsfc; Gp130; C76645; Lrp130; 3110001K13Rik
UniProt Protein Name
Leucine-rich PPR motif-containing protein, mitochondrial
UniProt Synonym Protein Names
130 kDa leucine-rich protein; LRP 130; mLRP130
Protein Family
Leucine-rich PPR motif-containing protein
UniProt Gene Name
Lrpprc
UniProt Synonym Gene Names
Lrp130; LRP 130; mLRP130
NCBI Protein Information
leucine-rich PPR motif-containing protein, mitochondrial

UniProt Comments for Lrpprc

May play a role in RNA metabolism in both nuclei and mitochondria. In the nucleus binds to HNRPA1-associated poly(A) mRNAs and is part of nmRNP complexes at late stages of mRNA maturation which are possibly associated with nuclear mRNA export. May bind mature mRNA in the nucleus outer membrane. In mitochondria binds to poly(A) mRNA. Plays a role in translation or stability of mitochondrially encoded cytochrome c oxidase (COX) subunits. May be involved in transcription regulation. Cooperates with PPARGC1A to regulate certain mitochondrially encoded genes and gluconeogenic genes and may regulate docking of PPARGC1A to transcription factors. Seems to be involved in the transcription regulation of the multidrug-related genes MDR1 and MVP. Part of a nuclear factor that binds to the invMED1 element of MDR1 and MVP gene promoters (). Binds single-stranded DNA.
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Research Articles on Lrpprc

1. Data suggest NT-Pgc-1alpha (alternative splicing isoform of nuclear protein Pgc-1alpha) is located in mitochondrial matrix in brown adipocytes, specifically enriched at D-loop region of mitochondrial DNA at promoter region of Lrpprc (leucine-rich PPR-motif containing protein); expression of NT-Pgc-1alpha (rather than Pgc-1alpha) in brown adipocytes appears to induce expression of electron transport chain complex proteins.
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with Lrpprc recombinant protein

 Products by Pathway  Pathway Diagram
 TNF-alpha NF-kB Signaling Pathway antibodies  TNF-alpha NF-kB Signaling Pathway Diagram

Diseases associated with Lrpprc recombinant protein

 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >10 publications with Lrpprc and Nervous System Diseases
 Brain Diseases Antibodies  >9 publications with Lrpprc and Brain Diseases
 Neoplasms Antibodies  >6 publications with Lrpprc and Neoplasms
 Liver Neoplasms Antibodies  >4 publications with Lrpprc and Liver Neoplasms
 Liver Diseases Antibodies  >4 publications with Lrpprc and Liver Diseases
 Adenocarcinoma Antibodies  >3 publications with Lrpprc and Adenocarcinoma
 Carcinoma, Hepatocellular Antibodies  >2 publications with Lrpprc and Carcinoma, Hepatocellular
 Leigh syndrome , French Canadian type Antibodies  >2 publications with Lrpprc and Leigh syndrome , French Canadian type
 Congenital Abnormalities Antibodies  >1 publications with Lrpprc and Congenital Abnormalities
 Carcinoma, Squamous Cell Antibodies  >1 publications with Lrpprc and Carcinoma, Squamous Cell

Organs/Tissues associated with Lrpprc recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >10 publications with Lrpprc and Liver
 Heart Antibodies  >6 publications with Lrpprc and Heart
 Muscle Antibodies  >3 publications with Lrpprc and Muscle
 Brain Antibodies  >3 publications with Lrpprc and Brain
 Adipose Tissue Antibodies  >1 publications with Lrpprc and Adipose Tissue
 Blood Antibodies  >1 publications with Lrpprc and Blood
 Skin Antibodies  >1 publications with Lrpprc and Skin
 Kidney Antibodies  >1 publications with Lrpprc and Kidney
 Eye Antibodies  >1 publications with Lrpprc and Eye
 Embryonic Tissue Antibodies  >1 publications with Lrpprc and Embryonic Tissue
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