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CDKN2C Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Special Promotion Catalog #: MBS128141
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The protein encoded by this gene is a member of the INK4 family of cyclin-dependent kinase inhibitors. This protein has been shown to interact with CDK4 or CDK6, and prevent the activation of the CDK kinases, thus function as a cell growth regulator that… More details

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Product Overview

Online Datasheet in PDF
Product Name
CDKN2C, Polyclonal Antibody
Full Product Name
CDKN2C Polyclonal Antibody
Product Gene Name
anti-CDKN2C antibody
Product Synonym Names
p18; INK4C; p18-INK4C
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Purity/Purification
Affinity Purification
Concentration
1mg/ml (lot specific)
Preparation and Storage
Store at -20 degree C (regular) or -80 degree C (long term). Avoid freeze / thaw cycles.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Molecular Weight
168
OMIM
603369
3D Structure
ModBase 3D Structure for P42773
Species
Human
Immunogen
Recombinant protein of human CDKN2C
Calculated Molecular Weight
18kDa

Product Categories/Family for anti-CDKN2C antibody

Polyclonal
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-CDKN2C antibody
Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
Application Notes for anti-CDKN2C antibody
WB: 1:500 - 1:2000
IHC: 1:50 - 1:200
IF: 1:50 - 1:100

Western Blot (WB) of anti-CDKN2C antibody

Western blot analysis of extracts of various cell lines, using CDKN2C antibody at 1:1000 dilution.
Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (MBS128200) at 1:10000 dilution.
Lysates/proteins: 25ug per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Detection: ECL Basic Kit.
Exposure time: 60s.
Rabbit Anti-CDKN2C Polyclonal Antibody – Cat# MBS128141

Immunohistochemistry (IHC) of anti-CDKN2C antibody

Immunohistochemistry of paraffin-embedded rat lung using CDKN2C antibody at dilution of 1:100 (40x lens).
Rabbit Anti-CDKN2C Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS128141

Immunohistochemistry (IHC) of anti-CDKN2C antibody

Immunohistochemistry of paraffin-embedded human stomach using CDKN2C antibody at dilution of 1:100 (40x lens).
Rabbit Anti-CDKN2C Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS128141

Immunohistochemistry (IHC) of anti-CDKN2C antibody

Immunohistochemistry of paraffin-embedded mouse lung using CDKN2C antibody at dilution of 1:100 (40x lens).
Rabbit Anti-CDKN2C Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS128141

Immunofluorescence (IF) of anti-CDKN2C antibody

Immunofluorescence analysis of HeLa cells using CDKN2C antibody. Blue: DAPI for nuclear staining.
Rabbit Anti-CDKN2C Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS128141

Other Notes

Small volumes of anti-CDKN2C antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CDKN2C purchase

MBS128141 is an antibody targeting CDKN2C. Also known as CDKN2C Polyclonal Antibody. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for CDKN2C. It may not necessarily be applicable to this product.

NCBI GI #
1168870
NCBI GeneID
1031
NCBI Accession #
P42773.1
UniProt Primary Accession #
P42773
UniProt Secondary Accession #
Q8TB83
UniProt Related Accession #
P42773
NCBI Official Full Name
Cyclin-dependent kinase 4 inhibitor C
NCBI Official Synonym Full Names
cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
NCBI Official Symbol
CDKN2C
NCBI Official Synonym Symbols
p18; INK4C; p18-INK4C
UniProt Protein Name
Cyclin-dependent kinase 4 inhibitor C
UniProt Synonym Protein Names
Cyclin-dependent kinase 6 inhibitor; p18-INK4c; p18-INK6
Protein Family
Cyclin-dependent kinase 4 inhibitor
UniProt Gene Name
CDKN2C
UniProt Synonym Gene Names
CDKN6
UniProt Entry Name
CDN2C_HUMAN
NCBI Protein Information
cyclin-dependent kinase 4 inhibitor C; p18-INK6; CDK6 inhibitor p18; cyclin-dependent inhibitor; cyclin-dependent kinase 6 inhibitor p18

UniProt Comments for CDKN2C

CDKN2C: Interacts strongly with CDK6, weakly with CDK4. Inhibits cell growth and proliferation with a correlated dependence on endogenous retinoblastoma protein RB. Heterodimer of p18 with CDK6. Highest levels found in skeletal muscle. Also found in pancreas and heart. Belongs to the CDKN2 cyclin-dependent kinase inhibitor family.

Protein type: Protein kinase, regulatory subunit; Inhibitor; Cell cycle regulation

Chromosomal Location of Human Ortholog: 1p32

Cellular Component: cytoplasm; nucleus; cytosol

Molecular Function: cyclin-dependent protein kinase inhibitor activity; protein binding; protein kinase binding

Biological Process: negative regulation of cell proliferation; negative regulation of phosphorylation; oligodendrocyte differentiation; negative regulation of cell growth; mitotic cell cycle; regulation of cyclin-dependent protein kinase activity; cell cycle arrest; G1/S transition of mitotic cell cycle
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Research Articles on CDKN2C

1. this studydemonstrated abundant levels of the critical negative cell-cycle regulators, p27(Kip1), its phosphorylated form, p-p27(S10), p18Ink4c, and GSK-3, in beta-cells of both adult human and mouse pancreatic islets, which contribute to maintenance of beta-cell quiescence.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CDKN2C antibody

 Reference Product  PubMed Publications
 CDKN1B antibody  >132 publications with CDKN2C and CDKN1B
 CDKN1A antibody  >112 publications with CDKN2C and CDKN1A
 CDK4 antibody  >101 publications with CDKN2C and CDK4
 CDK6 antibody  >77 publications with CDKN2C and CDK6
 CDKN2B antibody  >61 publications with CDKN2C and CDKN2B
 CCND1 antibody  >53 publications with CDKN2C and CCND1
 CDKN2D antibody  >41 publications with CDKN2C and CDKN2D
 E2F1 antibody  >7 publications with CDKN2C and E2F1
 SP1 antibody  >4 publications with CDKN2C and SP1

Pathways associated with anti-CDKN2C antibody

 Products by Pathway  Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle, Mitotic Pathway antibodies  Cell Cycle, Mitotic Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cellular Senescence Pathway antibodies  Cellular Senescence Pathway Diagram
 Cellular Responses To Stress Pathway antibodies  Cellular Responses To Stress Pathway Diagram
 Cyclin D Associated Events In G1 Pathway antibodies  Cyclin D Associated Events In G1 Pathway Diagram
 E2F Transcription Factor Network Pathway antibodies  E2F Transcription Factor Network Pathway Diagram
 G1 Phase Pathway antibodies  G1 Phase Pathway Diagram
 G1 To S Cell Cycle Control Pathway antibodies  G1 To S Cell Cycle Control Pathway Diagram

Diseases associated with anti-CDKN2C antibody

 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >35 publications with CDKN2C and Nervous System Diseases
 Brain Diseases Antibodies  >28 publications with CDKN2C and Brain Diseases
 Cell Transformation, Neoplastic Antibodies  >21 publications with CDKN2C and Cell Transformation, Neoplastic
 Adenocarcinoma Antibodies  >17 publications with CDKN2C and Adenocarcinoma
 Cardiovascular Diseases Antibodies  >16 publications with CDKN2C and Cardiovascular Diseases
 Breast Neoplasms Antibodies  >16 publications with CDKN2C and Breast Neoplasms
 Disease Models, Animal Antibodies  >16 publications with CDKN2C and Disease Models, Animal
 Hyperplasia Antibodies  >13 publications with CDKN2C and Hyperplasia
 Neoplasms, Experimental Antibodies  >13 publications with CDKN2C and Neoplasms, Experimental
 Liver Diseases Antibodies  >11 publications with CDKN2C and Liver Diseases

Organs/Tissues associated with anti-CDKN2C antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >41 publications with CDKN2C and Blood
 Brain Antibodies  >31 publications with CDKN2C and Brain
 Bone Antibodies  >25 publications with CDKN2C and Bone
 Bone Marrow Antibodies  >21 publications with CDKN2C and Bone Marrow
 Liver Antibodies  >17 publications with CDKN2C and Liver
 Pancreas Antibodies  >15 publications with CDKN2C and Pancreas
 Muscle Antibodies  >15 publications with CDKN2C and Muscle
 Kidney Antibodies  >11 publications with CDKN2C and Kidney
 Lung Antibodies  >11 publications with CDKN2C and Lung
 Testis Antibodies  >10 publications with CDKN2C and Testis
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