GSK3B Antibody – Rabbit

GSK3B: a proline-directed protein kinase of the GSK family. Phosphorylates and inactivates glycogen synthase. Participates in the Wnt signaling pathway. Involved in energy metabolism, neuronal cell development, and body pattern formation

Protein type: Protein kinase, CMGC; Kinase, protein; EC 2.7.11.1; EC 2.7.11.26; Protein kinase, Ser/Thr (non-receptor); CMGC group; GSK family; GSK subfamily

Chromosomal Location of Human Ortholog: 3q13.3

Cellular Component: nucleoplasm; centrosome; growth cone; cell soma; perinuclear region of cytoplasm; cytoplasm; dendritic spine; plasma membrane; dendritic shaft; ribonucleoprotein complex; nucleus; beta-catenin destruction complex; cytosol; lipid raft

Molecular Function: p53 binding; beta-catenin binding; protein kinase binding; integrin binding; NF-kappaB binding; ionotropic glutamate receptor binding; protein serine/threonine kinase activity; protein binding; ubiquitin protein ligase binding; tau-protein kinase activity; kinase activity; tau protein binding; ATP binding

Biological Process: fat cell differentiation; glycogen metabolic process; circadian rhythm; axon guidance; negative regulation of MAP kinase activity; re-entry into mitotic cell cycle; genetic imprinting; nerve growth factor receptor signaling pathway; positive regulation of protein binding; protein amino acid autophosphorylation; positive regulation of axon extension; response to lithium ion; Wnt receptor signaling pathway through beta-catenin; protein amino acid phosphorylation; positive regulation of protein export from nucleus; protein export from nucleus; negative regulation of protein binding; positive regulation of cell-matrix adhesion; ER overload response; myoblast fusion; negative regulation of glycogen biosynthetic process; response to drug; epidermal growth factor receptor signaling pathway; regulation of microtubule-based process; cell migration; phosphoinositide-mediated signaling; fibroblast growth factor receptor signaling pathway; hippocampus development; negative regulation of dendrite morphogenesis; negative regulation of NFAT protein import into nucleus; positive regulation of peptidyl-serine phosphorylation; organ morphogenesis; peptidyl-serine phosphorylation; negative regulation of neuron maturation; positive regulation of protein complex assembly; establishment of cell polarity; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of protein catabolic process; innate immune response; epithelial to mesenchymal transition; positive regulation of transcription from RNA polymerase II promoter; negative regulation of protein complex assembly; regulation of neuronal synaptic plasticity; negative regulation of apoptosis