Rabbit Anti-CFL1 Antibody – Cat# MBS128468

Immunohistochemistry of paraffin-embedded human lung carcinoma using Phospho-CFL1-Y139 antibody.

CFL1 Antibody – Rabbit

Name: CFL1 Antibody; Rabbit; Human/Mouse/Rat-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS128468
Price: 245 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS128468

The protein encoded by this gene can polymerize and depolymerize F-actin and G-actin in a pH-dependent manner. Increased phosphorylation of this protein by LIM kinase aids in Rho-induced reorganization of the actin cytoskeleton. Cofilin is a widely… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

CFL1-Y139, Antibody

Full Product Name

Phospho-CFL1-Y139 Polyclonal Antibody

Product Gene Name

anti-CFL1 antibody

Product Synonym Names

Phospho-CFL1-Y139: CFL

Isotype

IgG

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Purity/Purification

Affinity Purification

Concentration

1mg/ml (lot specific)

Preparation and Storage

Store at -20 degree C (regular) or -80 degree C (long term). Avoid freeze / thaw cycles.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Molecular Weight

166

OMIM

601442

3D Structure

ModBase 3D Structure for P23528

Species

Human

Route

Synthetic Peptide

Immunogen

A phospho specific peptide corresponding to residues surrounding Y139 of human CFL1

Calculated Molecular Weight

19kDa

Product Categories/Family for anti-CFL1 antibody

Phosphorylation

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Applications Tested/Suitable for anti-CFL1 antibody

Immunohistochemistry (IHC)

Application Notes for anti-CFL1 antibody

IHC: 1:50 - 1:100

Other Notes

Small volumes of anti-CFL1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CFL1 purchase

MBS128468 is an antibody targeting CFL1. Also known as Phospho-CFL1-Y139 Polyclonal Antibody. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for CFL1. It may not necessarily be applicable to this product.

NCBI GI #

116848

NCBI GeneID

1072

NCBI Accession #

P23528.3

UniProt Primary Accession #

P23528

UniProt Secondary Accession #

Q53Y87; Q9UCA2; B3KUQ1

UniProt Related Accession #

P23528

NCBI Official Full Name

Cofilin-1

NCBI Official Synonym Full Names

cofilin 1 (non-muscle)

NCBI Official Symbol

CFL1

NCBI Official Synonym Symbols

CFL; HEL-S-15

UniProt Protein Name

Cofilin-1

UniProt Synonym Protein Names

18 kDa phosphoprotein; p18; Cofilin, non-muscle isoform

Protein Family

Cofilin

UniProt Gene Name

CFL1

UniProt Synonym Gene Names

CFL; p18

UniProt Entry Name

COF1_HUMAN

NCBI Protein Information

cofilin-1; p18; 18 kDa phosphoprotein; cofilin, non-muscle isoform; epididymis secretory protein Li 15

UniProt Comments for CFL1

Cofilin-1: a cytoskeletal protein that controls actin depolymerization. Has a 5-10-fold higher affinity for ATP-actin monomers than cofilin-1. May promote filament assembly rather than disassembly. Two alternatively spliced variants are described. Isoform b is expressed predominantly in skeletal muscle and heart, while isoform a is expressed in various tissues.

Protein type: Motility/polarity/chemotaxis; Cytoskeletal; Nuclear receptor co-regulator

Chromosomal Location of Human Ortholog: 11q13

Cellular Component: extracellular space; cortical actin cytoskeleton; focal adhesion; nuclear matrix; membrane; cytoplasm; intercellular junction; nucleus; vesicle

Molecular Function: protein binding; actin binding

Biological Process: axon guidance; platelet activation; actin filament depolymerization; positive regulation of actin filament depolymerization; response to virus; negative regulation of cell size; cytoskeleton organization and biogenesis; response to amino acid stimulus; protein amino acid phosphorylation; Rho protein signal transduction; neural fold formation; platelet degranulation; cytokinesis after mitosis; protein import into nucleus; establishment of cell polarity; ephrin receptor signaling pathway; innate immune response; regulation of cell morphogenesis; blood coagulation; actin cytoskeleton organization and biogenesis; neural crest cell migration; negative regulation of apoptosis

Research Articles on CFL1

1. It provides a brief overview of the current knowledge about the central role of cofilin/actin rods formation, where its dysregulation and malfunction might be the trigger to neurodegeneration.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CFL1 antibody

Reference Product	PubMed Publications
LIMK1 antibody	>16 publications with CFL1 and LIMK1
SSH1 antibody	>6 publications with CFL1 and SSH1
PFN1 antibody	>4 publications with CFL1 and PFN1
ACTG1 antibody	>2 publications with CFL1 and ACTG1
ACTB antibody	>2 publications with CFL1 and ACTB

Pathways associated with anti-CFL1 antibody

Products by Pathway	Pathway Diagram
Axon Guidance Pathway antibodies	Axon Guidance Pathway Diagram
Axon Guidance Pathway antibodies	Axon Guidance Pathway Diagram
Axon Guidance Pathway antibodies	Axon Guidance Pathway Diagram
BDNF Signaling Pathway antibodies	BDNF Signaling Pathway Diagram
CDC42 Signaling Events Pathway antibodies	CDC42 Signaling Events Pathway Diagram
CXCR4-mediated Signaling Events Pathway antibodies	CXCR4-mediated Signaling Events Pathway Diagram
Developmental Biology Pathway antibodies	Developmental Biology Pathway Diagram
EPH-Ephrin Signaling Pathway antibodies	EPH-Ephrin Signaling Pathway Diagram
EPHB-mediated Forward Signaling Pathway antibodies	EPHB-mediated Forward Signaling Pathway Diagram
Fc Gamma R-mediated Phagocytosis Pathway antibodies	Fc Gamma R-mediated Phagocytosis Pathway Diagram

Diseases associated with anti-CFL1 antibody

Disease Name	Pubmed Publications
Nervous System Diseases Antibodies	>9 publications with CFL1 and Nervous System Diseases
Neoplasm Metastasis Antibodies	>9 publications with CFL1 and Neoplasm Metastasis
Disease Models, Animal Antibodies	>7 publications with CFL1 and Disease Models, Animal
Breast Neoplasms Antibodies	>7 publications with CFL1 and Breast Neoplasms
Inflammation Antibodies	>5 publications with CFL1 and Inflammation
Neoplasms, Experimental Antibodies	>3 publications with CFL1 and Neoplasms, Experimental
Neoplasm Invasiveness Antibodies	>3 publications with CFL1 and Neoplasm Invasiveness
Cardiovascular Diseases Antibodies	>2 publications with CFL1 and Cardiovascular Diseases
Memory Disorders Antibodies	>2 publications with CFL1 and Memory Disorders
Kidney Diseases Antibodies	>1 publications with CFL1 and Kidney Diseases

Organs/Tissues associated with anti-CFL1 antibody

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>18 publications with CFL1 and Brain
Muscle Antibodies	>14 publications with CFL1 and Muscle
Blood Antibodies	>12 publications with CFL1 and Blood
Nerve Antibodies	>11 publications with CFL1 and Nerve
Lung Antibodies	>8 publications with CFL1 and Lung
Kidney Antibodies	>6 publications with CFL1 and Kidney
Uterus Antibodies	>5 publications with CFL1 and Uterus
Vascular Antibodies	>4 publications with CFL1 and Vascular
Eye Antibodies	>3 publications with CFL1 and Eye
Embryonic Tissue Antibodies	>3 publications with CFL1 and Embryonic Tissue