Rabbit Anti-IL10RA Antibody – Cat# MBS128551

Western blot analysis of extracts from HeLa cells, using Phospho-IL10RA-S319/S323 antibody.
Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (MBS128200) at 1:10000 dilution.
Lysates/proteins: 25ug per lane.
Blocking buffer: 3% BSA.

S319/S323 (IL10RA) Antibody – Rabbit

Name: IL10RA Antibody; Rabbit; Human-Reactive; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS128551
Price: 440 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS128551

The protein encoded by this gene is a receptor for interleukin 10. This protein is structurally related to interferon receptors. It has been shown to mediate the immunosuppressive signal of interleukin 10, and thus inhibits the synthesis of proinflammatory… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

IL10RA-S319/S323, Antibody

Full Product Name

Phospho-IL10RA-S319/S323 Polyclonal Antibody

Product Gene Name

anti-IL10RA antibody

Product Synonym Names

Phospho-IL10RA-S319/S323: CD210; IL10R; CD210a; CDW210A; HIL-10R; IL-10R1

Isotype

IgG

Host

Rabbit

Species Reactivity

Human

Purity/Purification

Affinity Purification

Concentration

1mg/ml (lot specific)

Preparation and Storage

Store at -20 degree C (regular) or -80 degree C (long term). Avoid freeze / thaw cycles.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Molecular Weight

578

OMIM

gene 613148

3D Structure

ModBase 3D Structure for Q13651

Species

Human

Route

Synthetic Peptide

Immunogen

A phospho specific peptide corresponding to residues surrounding S319/S323 of human IL10RA

Calculated Molecular Weight

63kDa

Product Categories/Family for anti-IL10RA antibody

Phosphorylation

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Applications Tested/Suitable for anti-IL10RA antibody

Western Blot (WB)

Application Notes for anti-IL10RA antibody

WB: 1:500 - 1:2000

Other Notes

Small volumes of anti-IL10RA antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for IL10RA purchase

MBS128551 is an antibody targeting IL10RA. Also known as Phospho-IL10RA-S319/S323 Polyclonal Antibody. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for IL10RA. It may not necessarily be applicable to this product.

NCBI GI #

322510034

NCBI GeneID

3587

NCBI Accession #

Q13651.2

UniProt Primary Accession #

Q13651

UniProt Secondary Accession #

A8K6I0; B0YJ27

UniProt Related Accession #

Q13651

NCBI Official Full Name

Interleukin-10 receptor subunit alpha

NCBI Official Synonym Full Names

interleukin 10 receptor, alpha

NCBI Official Symbol

IL10RA

NCBI Official Synonym Symbols

CD210; IL10R; CD210a; CDW210A; HIL-10R; IL-10R1

UniProt Protein Name

Interleukin-10 receptor subunit alpha

UniProt Synonym Protein Names

CDw210a; Interleukin-10 receptor subunit 1; IL-10R subunit 1; IL-10R1; CD_antigen: CD210

Protein Family

Interleukin-10 receptor

UniProt Gene Name

IL10RA

UniProt Synonym Gene Names

IL10R; IL-10 receptor subunit alpha; IL-10R subunit alpha; IL-10RA; IL-10R subunit 1; IL-10R1

UniProt Entry Name

I10R1_HUMAN

NCBI Protein Information

interleukin-10 receptor subunit alpha; IL-10RA; IL-10R subunit 1; IL-10R subunit alpha; IL-10 receptor subunit alpha; interleukin-10 receptor subunit 1; interleukin-10 receptor alpha chain

UniProt Comments for IL10RA

IL10RA: a receptor for interleukin 10 structurally related to interferon receptors. Mediates the immunosuppressive signal of interleukin 10, and thus inhibits the synthesis of proinflammatory cytokines. This receptor is reported to promote survival of progenitor myeloid cells through the insulin receptor substrate-2/PI 3-kinase/AKT pathway. Activation of this receptor leads to tyrosine phosphorylation of JAK1 and TYK2 kinases.

Protein type: Receptor, cytokine; Membrane protein, integral

Chromosomal Location of Human Ortholog: 11q23

Cellular Component: plasma membrane; integral to membrane

Molecular Function: protein binding; interleukin-10 binding; signal transducer activity; interleukin-10 receptor activity; receptor activity

Biological Process: cytokine and chemokine mediated signaling pathway; response to lipopolysaccharide

Disease: Inflammatory Bowel Disease 28, Autosomal Recessive

Research Articles on IL10RA

1. Very early onset inflammatory bowel disease associated with aberrant trafficking of IL-10R1 and cure by T cell replete haploidentical bone marrow transplantation.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-IL10RA antibody

Reference Product	PubMed Publications
IL10 antibody	>32 publications with IL10RA and IL10
IL10RB antibody	>16 publications with IL10RA and IL10RB
JAK1 antibody	>1 publications with IL10RA and JAK1

Pathways associated with anti-IL10RA antibody

Products by Pathway	Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Epstein-Barr Virus Infection Pathway antibodies	Epstein-Barr Virus Infection Pathway Diagram
Epstein-Barr Virus Infection Pathway antibodies	Epstein-Barr Virus Infection Pathway Diagram
Jak-STAT Signaling Pathway antibodies	Jak-STAT Signaling Pathway Diagram
Jak-STAT Signaling Pathway antibodies	Jak-STAT Signaling Pathway Diagram
Toxoplasmosis Pathway antibodies	Toxoplasmosis Pathway Diagram
Toxoplasmosis Pathway antibodies	Toxoplasmosis Pathway Diagram
Tuberculosis Pathway antibodies	Tuberculosis Pathway Diagram
Tuberculosis Pathway antibodies	Tuberculosis Pathway Diagram

Diseases associated with anti-IL10RA antibody

Disease Name	Pubmed Publications
Inflammation Antibodies	>15 publications with IL10RA and Inflammation
Necrosis Antibodies	>6 publications with IL10RA and Necrosis
Skin Diseases Antibodies	>3 publications with IL10RA and Skin Diseases
Brain Diseases Antibodies	>2 publications with IL10RA and Brain Diseases
Liver Diseases Antibodies	>2 publications with IL10RA and Liver Diseases
Lung Diseases Antibodies	>1 publications with IL10RA and Lung Diseases
Disease Models, Animal Antibodies	>1 publications with IL10RA and Disease Models, Animal
Prenatal Exposure Delayed Effects Antibodies	>1 publications with IL10RA and Prenatal Exposure Delayed Effects
Kidney Diseases Antibodies	>1 publications with IL10RA and Kidney Diseases
Hyperplasia Antibodies	>1 publications with IL10RA and Hyperplasia

Organs/Tissues associated with anti-IL10RA antibody

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>19 publications with IL10RA and Blood
Skin Antibodies	>5 publications with IL10RA and Skin
Bone Antibodies	>4 publications with IL10RA and Bone
Intestine Antibodies	>4 publications with IL10RA and Intestine
Vascular Antibodies	>3 publications with IL10RA and Vascular
Brain Antibodies	>3 publications with IL10RA and Brain
Lung Antibodies	>2 publications with IL10RA and Lung
Tonsil Antibodies	>1 publications with IL10RA and Tonsil
Pancreas Antibodies	>1 publications with IL10RA and Pancreas
Pharynx Antibodies	>1 publications with IL10RA and Pharynx