Rabbit Anti-TBX5 Polyclonal Antibody – Cat# MBS128641

Western blot analysis of extracts of HeLa cells, using TBX5 antibody.
Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (MBS128200) at 1:10000 dilution.
Lysates/proteins: 25ug per lane.
Blocking buffer: 3% nonfat dry milk in TBST.

TBX5 Antibody – Rabbit Polyclonal

Name: TBX5 Antibody; Polyclonal; Rabbit; Human/Mouse/Rat-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS128641
Price: 360 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS128641

This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene is closely linked to related… More details

DISCONTINUED
Click here to view our similar product(s) OR click here to contact our technical support team for suitable replacement.

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

TBX5, Polyclonal Antibody

Full Product Name

TBX5 Polyclonal Antibody

Product Gene Name

anti-TBX5 antibody

Product Synonym Names

HOS

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Purity/Purification

Affinity Purification

Concentration

1mg/ml (lot specific)

Preparation and Storage

Store at -20 degree C (regular) or -80 degree C (long term). Avoid freeze / thaw cycles.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Molecular Weight

518

OMIM

phenotype 601620

3D Structure

ModBase 3D Structure for Q99593

Species

Human

Immunogen

Recombinant protein of human TBX5

Calculated Molecular Weight

57kDa

Product Categories/Family for anti-TBX5 antibody

Polyclonal

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Applications Tested/Suitable for anti-TBX5 antibody

Western Blot (WB)

Application Notes for anti-TBX5 antibody

WB: 1:200-1:2000

Other Notes

Small volumes of anti-TBX5 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TBX5 purchase

MBS128641 is an antibody targeting TBX5. Also known as TBX5 Polyclonal Antibody. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for TBX5. It may not necessarily be applicable to this product.

NCBI GI #

12644474

NCBI GeneID

6910

NCBI Accession #

Q99593.2

UniProt Primary Accession #

Q99593

UniProt Secondary Accession #

O15301; Q96TB0; Q9Y4I2; A6ND77

UniProt Related Accession #

Q99593

NCBI Official Full Name

T-box transcription factor TBX5

NCBI Official Synonym Full Names

T-box 5

NCBI Official Symbol

TBX5

NCBI Official Synonym Symbols

HOS

UniProt Protein Name

T-box transcription factor TBX5

Protein Family

T-box transcription factor

UniProt Gene Name

TBX5

UniProt Synonym Gene Names

T-box protein 5

UniProt Entry Name

TBX5_HUMAN

NCBI Protein Information

T-box transcription factor TBX5; T-box protein 5

UniProt Comments for TBX5

TBX5: Involved in the transcriptional regulation of genes required for mesoderm differentiation. Probably plays a role in limb pattern formation. Defects in TBX5 are the cause of Holt-Oram syndrome (HOS). HOS is a developmental disorder affecting the heart and upper limbs. It is characterized by thumb anomaly and atrial septal defects. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: DNA-binding; Transcription factor

Chromosomal Location of Human Ortholog: 12q24.1

Cellular Component: nucleoplasm; transcription factor complex; cytoplasm; nucleus

Molecular Function: protein binding; DNA binding; sequence-specific DNA binding; transcription factor activity; transcription factor binding

Biological Process: embryonic forelimb morphogenesis; pericardium development; transcription initiation from RNA polymerase II promoter; heart development; positive regulation of transcription, DNA-dependent; pattern specification process; cardiac muscle cell differentiation; forelimb morphogenesis; negative regulation of cell proliferation; cell-cell signaling; apoptotic nuclear changes; negative regulation of cardiac muscle cell proliferation; positive regulation of cardioblast differentiation; morphogenesis of an epithelium; gene expression; positive regulation of transcription from RNA polymerase II promoter; negative regulation of cell migration; lung development; embryonic limb morphogenesis; positive regulation of cardiac muscle cell proliferation

Disease: Holt-oram Syndrome

Research Articles on TBX5

1. Our results indicate that rs3825214 conferred a significant risk of lone AF in this Chinese Han population.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-TBX5 antibody

Reference Product	PubMed Publications
NKX2-5 antibody	>120 publications with TBX5 and NKX2-5
GATA4 antibody	>111 publications with TBX5 and GATA4
FGF10 antibody	>23 publications with TBX5 and FGF10
NPPA antibody	>16 publications with TBX5 and NPPA
SALL4 antibody	>15 publications with TBX5 and SALL4
BMP2 antibody	>9 publications with TBX5 and BMP2
GJA5 antibody	>2 publications with TBX5 and GJA5
WWTR1 antibody	>1 publications with TBX5 and WWTR1

Pathways associated with anti-TBX5 antibody

Products by Pathway	Pathway Diagram
Cardiac Progenitor Differentiation Pathway antibodies	Cardiac Progenitor Differentiation Pathway Diagram
Gene Expression Pathway antibodies	Gene Expression Pathway Diagram
Generic Transcription Pathway antibodies	Generic Transcription Pathway Diagram
Heart Development Pathway antibodies	Heart Development Pathway Diagram
YAP1- And WWTR1 (TAZ)-stimulated Gene Expression Pathway antibodies	YAP1- And WWTR1 (TAZ)-stimulated Gene Expression Pathway Diagram

Diseases associated with anti-TBX5 antibody

Disease Name	Pubmed Publications
Heart Diseases Antibodies	>148 publications with TBX5 and Heart Diseases
Heart Defects, Congenital Antibodies	>142 publications with TBX5 and Heart Defects, Congenital
Holt-Oram syndrome Antibodies	>111 publications with TBX5 and Holt-Oram syndrome
Limb Deformities, Congenital Antibodies	>56 publications with TBX5 and Limb Deformities, Congenital
Heart Septal Defects, Atrial Antibodies	>41 publications with TBX5 and Heart Septal Defects, Atrial
Heart Septal Defects, Ventricular Antibodies	>22 publications with TBX5 and Heart Septal Defects, Ventricular
Eye Abnormalities Antibodies	>9 publications with TBX5 and Eye Abnormalities
Disease Models, Animal Antibodies	>9 publications with TBX5 and Disease Models, Animal
Abnormalities, Drug-Induced Antibodies	>7 publications with TBX5 and Abnormalities, Drug-Induced
Fibrosis Antibodies	>4 publications with TBX5 and Fibrosis

Organs/Tissues associated with anti-TBX5 antibody

Organ/Tissue Name	Pubmed Publications
Heart Antibodies	>319 publications with TBX5 and Heart
Embryonic Tissue Antibodies	>125 publications with TBX5 and Embryonic Tissue
Lung Antibodies	>12 publications with TBX5 and Lung
Liver Antibodies	>4 publications with TBX5 and Liver
Trachea Antibodies	>3 publications with TBX5 and Trachea
Uncharacterized Tissue Antibodies	>1 publications with TBX5 and Uncharacterized Tissue
Prostate Antibodies	>1 publications with TBX5 and Prostate
Esophagus Antibodies	>1 publications with TBX5 and Esophagus