Ubiquitin Carboxyl-Terminal Hydrolase 2 (USP2) Rat Recombinant Protein

Hydrolase that deubiquitinates polyubiquitinated target proteins such as MDM2, MDM4 and CCND1 (). Isoform 1 and isoform 2 possess both ubiquitin-specific peptidase and isopeptidase activities (PubMed:12107281). Deubiquitinates MDM2 without reversing MDM2-mediated p53/TP53 ubiquitination and thus indirectly promotes p53/TP53 degradation and limits p53 activity (). Has no deubiquitinase activity against p53/TP53 (). Prevents MDM2-mediated degradation of MDM4 (). Plays a role in the G1/S cell-cycle progression in normal and cancer cells (). Regulates the circadian clock by modulating its intrinsic circadian rhythm and its capacity to respond to external cues (PubMed:23213472). Associates with clock proteins and deubiquitinates core clock component PER1 but does not affect its overall stability (PubMed:23213472). Regulates the nucleocytoplasmic shuttling and nuclear retention of PER1 and its repressive role on the clock transcription factors CLOCK and ARNTL/BMAL1 (). Plays a role in the regulation of myogenic differentiation of embryonic muscle cells (PubMed:12107281).