ZDHHC17 Antibody – Rabbit Polyclonal

HIP14: a palmitoyltransferase specific for a subset of neuronal proteins, including SNAP25, PSD-95, GAD2, SYT1 and Huntingtin. May be involved in the sorting or targeting of critical proteins involved in the initiating events of endocytosis at the plasma membrane. May be involved in the NF-kappa-B signaling pathway. Can cause cellular transformation, and is up-regulated in a number of types of human tumors. Expressed in all brain regions. Expression is highest in the cortex, cerebellum, occipital lobe and caudate, and lowest in the spinal cord. Expression is also seen in testis, pancreas, heart and kidney. Three alternatively spliced isoforms have been described.

Protein type: EC 2.3.1.225; Transferase; Membrane protein, multi-pass; Membrane protein, integral; Tumor suppressor

Chromosomal Location of Human Ortholog: 12q21.2

Cellular Component: Golgi membrane; Golgi apparatus; intracellular membrane-bound organelle; cytoplasm; integral to membrane

Molecular Function: identical protein binding; signal transducer activity; protein binding; zinc ion binding; palmitoyltransferase activity; magnesium ion transmembrane transporter activity; protein-cysteine S-palmitoleyltransferase activity

Biological Process: protein palmitoylation; positive regulation of I-kappaB kinase/NF-kappaB cascade; lipoprotein transport; signal transduction; magnesium ion transport