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E3 Ubiquitin-Protein Ligase Praja-1 (PJA1) Human Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1290494

MBS1290494 is a recombinant protein targeting PJA1. Also known as Recombinant Human E3 ubiquitin-protein ligase Praja-1 (PJA1). Host: E Coli or Yeast or Baculovirus or Mammalian Cell. More details

$1455 / 0.02 mg (E-Coli) +1 FREE 8GB USB
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
E3 ubiquitin-protein ligase Praja-1 (PJA1), Recombinant Protein
Full Product Name
Recombinant Human E3 ubiquitin-protein ligase Praja-1 (PJA1)
Product Gene Name
PJA1 recombinant protein
Product Synonym Gene Name
PJA1
Sequence
MGQESSKPVW PNPTGGYQSN TGRRYGRRHA YVSFRPPTSQ RERIASQRKT NSEVPMHRSA PSQTTKRSRS PFSTTRRSWD DSESSGTNLN IDNEDYSRYP PREYRASGSR RGMAYGHIDS YGADDSEEEG AGPVERPPVR GKTGKFKDDK LYDPEKGARS LAGPPPHFSS FSRDVREERD KLDPVPAARC SASRADFLPQ SSVASQSSSE GKLATKGDSS ERERREQNLP ARPSRAPVSI CGGGENTSKS AEEPVVRPKI RNLASPNCVK PKIFFDTDDD DDMPHSTSRW RDTANDNEGH SDGLARRGRG ESSSGYPEPK YPEDKREARS DQVKPEKVPR RRRTMADPDF WTHSDDYYKY CDEDSDSDKE WIAALRRKYR SREQTLSSSG ESWETLPGKE EREPPQAKVS ASTGTSPGPG ASASAGAGAG ASAGSNGSNY LEEVREPSLQ EEQASLEEGE IPWLQYHEND SSSEGDNDSG HELMQPGVFM LDGNNNLEDD SSVSEDLEVD WSLFDGFADG LGVAEAISYV DPQFLTYMAL EERLAQAMET ALAHLESLAV DVEVANPPAS KESIDALPEI LVTEDHGAVG QEMCCPICCS EYVKGEVATE LPCHHYFHKP CVSIWLQKSG TCPVCRCMFP PPL
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Molecular Weight
64,729 Da
Sequence Positions
1-643, Full length protein
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
OMIM
300420
3D Structure
ModBase 3D Structure for Q8NG27
Species
Human
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of PJA1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for PJA1. It may not necessarily be applicable to this product.

NCBI GI #
74048537
NCBI GeneID
64219
NCBI Accession #
NP_001027568.1
UniProt Primary Accession #
Q8NG27
UniProt Secondary Accession #
Q5JUT8; Q5JUT9; Q8NG28; Q9HAC1; A2A322
UniProt Related Accession #
Q8NG27
GenBank Nucleotide #
NM_001032396.2
NCBI Official Full Name
E3 ubiquitin-protein ligase Praja-1 isoform b
NCBI Official Synonym Full Names
praja ring finger ubiquitin ligase 1
NCBI Official Symbol
PJA1
NCBI Official Synonym Symbols
RNF70; PRAJA1
UniProt Protein Name
E3 ubiquitin-protein ligase Praja-1
UniProt Synonym Protein Names
RING finger protein 70; RING-type E3 ubiquitin transferase Praja-1Curated
Protein Family
E3 ubiquitin-protein ligase
UniProt Gene Name
PJA1
UniProt Synonym Gene Names
RNF70; Praja1
NCBI Protein Information
E3 ubiquitin-protein ligase Praja-1

NCBI Summary for PJA1

This gene encodes an enzyme that has E2-dependent E3 ubiquitin-protein ligase activity. This enzyme belongs to a class of ubiquitin ligases that include a RING finger motif, and it can interact with the E2 ubiquitin-conjugating enzyme UbcH5B. This gene is located in an area of chromosome X where several X-linked cognitive disability disorders have been associated, and it has also been found as part of a contiguous gene deletion associated with craniofrontonasal syndrome, though a direct link to any disorder has yet to be demonstrated. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]
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UniProt Comments for PJA1

Has E2-dependent E3 ubiquitin-protein ligase activity. Ubiquitinates MAGED1 antigen leading to its subsequent degradation by proteasome (). May be involved in protein sorting.

Research Articles on PJA1

1. Data provide clues into novel aspects of Praja1 function.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with PJA1 recombinant protein

 Reference Product  PubMed Publications
 MAGED1 recombinant protein  >1 publications with PJA1 and MAGED1

Pathways associated with PJA1 recombinant protein

 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Antigen Processing: Ubiquitination & Proteasome Degradation Pathway antibodies  Antigen Processing: Ubiquitination & Proteasome Degradation Pathway Diagram
 Class I MHC Mediated Antigen Processing & Presentation Pathway antibodies  Class I MHC Mediated Antigen Processing & Presentation Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram

Diseases associated with PJA1 recombinant protein

 Disease Name  Pubmed Publications
 Congenital Abnormalities Antibodies  >3 publications with PJA1 and Congenital Abnormalities
 CRANIOFRONTONASAL SYNDROME Antibodies  >2 publications with PJA1 and CRANIOFRONTONASAL SYNDROME
 Anemia Antibodies  >1 publications with PJA1 and Anemia
 Neoplasms Antibodies  >1 publications with PJA1 and Neoplasms

Organs/Tissues associated with PJA1 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >4 publications with PJA1 and Brain
 Liver Antibodies  >2 publications with PJA1 and Liver
 Vascular Antibodies  >1 publications with PJA1 and Vascular
 Nerve Antibodies  >1 publications with PJA1 and Nerve
 Kidney Antibodies  >1 publications with PJA1 and Kidney
 Testis Antibodies  >1 publications with PJA1 and Testis
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