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PIK3R3 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Special Promotion Catalog #: MBS129084
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PIK3R3 (phosphoinositide-3-kinase, regulatory subunit 3 (gamma)) is a protein-coding gene. GO annotations related to this gene include 1-phosphatidylinositol-3-kinase activity and phosphatidylinositol 3-kinase regulator activity. An important paralog of this… More details

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Product Overview

Product Name
PIK3R3, Polyclonal Antibody
Full Product Name
PIK3R3 Polyclonal Antibody
Product Gene Name
anti-PIK3R3 antibody
Product Synonym Names
p55; p55-GAMMA
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Purity/Purification
Affinity Purification
Concentration
1mg/ml (lot specific)
Preparation and Storage
Store at -20 degree C (regular) or -80 degree C (long term). Avoid freeze / thaw cycles.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Molecular Weight
461
OMIM
606076
3D Structure
ModBase 3D Structure for Q92569
Species
Human
Route
Synthetic Peptide
Immunogen
A synthetic peptide of human PIK3R3
Calculated Molecular Weight
54kDa

Product Categories/Family for anti-PIK3R3 antibody

Polyclonal
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-PIK3R3 antibody
Western Blot (WB), Immunoprecipitation (IP)
Application Notes for anti-PIK3R3 antibody
WB: 1:500 - 1:2000
IP: 1:20 - 1:50

Western Blot (WB) of anti-PIK3R3 antibody

Western blot analysis of extracts of MDA-MB-453 cells, using PIK3R3 antibody.
Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (MBS128200) at 1:10000 dilution.
Lysates/proteins: 25ug per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Rabbit Anti-PIK3R3 Polyclonal Antibody – Cat# MBS129084

Other Notes

Small volumes of anti-PIK3R3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PIK3R3 purchase

MBS129084 is an antibody targeting PIK3R3. Also known as PIK3R3 Polyclonal Antibody. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for PIK3R3. It may not necessarily be applicable to this product.

NCBI GI #
317373310
NCBI GeneID
8503
NCBI Accession #
Q92569.2
UniProt Primary Accession #
Q92569
UniProt Secondary Accession #
O60482; Q5T4P1; Q5T4P2; B2R9C1; D3DQ12
UniProt Related Accession #
Q92569
NCBI Official Full Name
Phosphatidylinositol 3-kinase regulatory subunit gamma
NCBI Official Synonym Full Names
phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
NCBI Official Symbol
PIK3R3
NCBI Official Synonym Symbols
p55; p55PIK; p55-GAMMA
UniProt Protein Name
Phosphatidylinositol 3-kinase regulatory subunit gamma
UniProt Synonym Protein Names
Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma; PI3-kinase subunit p55-gamma; PtdIns-3-kinase regulatory subunit p55-gamma; p55PIK
Protein Family
Phosphatidylinositol 3-kinase regulatory
UniProt Gene Name
PIK3R3
UniProt Synonym Gene Names
PI3-kinase regulatory subunit gamma; PI3K regulatory subunit gamma; PtdIns-3-kinase regulatory subunit gamma; PI3-kinase subunit p55-gamma; PtdIns-3-kinase regulatory subunit p55-gamma
UniProt Entry Name
P55G_HUMAN
NCBI Protein Information
phosphatidylinositol 3-kinase regulatory subunit gamma; PI3-kinase subunit p55-gamma; PI3K regulatory subunit gamma; PI3-kinase regulatory subunit gamma; ptdIns-3-kinase regulatory subunit p55-gamma; phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma; phosphoinositide-3-kinase, regulatory subunit, polypeptide 3 (p55, gamma); phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 3 (p55, gamma)

UniProt Comments for PIK3R3

PIK3R3: Binds to activated (phosphorylated) protein-tyrosine kinases through its SH2 domain and regulates their kinase activity. During insulin stimulation, it also binds to IRS-1. Heterodimer of a regulatory subunit PIK3R3 and a p110 catalytic subunit (PIK3CA, PIK3CB or PIK3CD). Interacts with AXL. Highest levels in brain and testis. Lower levels in adipose tissue, kidney, heart, lung and skeletal muscle. Belongs to the PI3K p85 subunit family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Motility/polarity/chemotaxis; Kinase, lipid

Chromosomal Location of Human Ortholog: 1p34.1

Cellular Component: cytosol; phosphoinositide 3-kinase complex

Molecular Function: protein binding; 1-phosphatidylinositol-3-kinase activity; phosphoinositide 3-kinase regulator activity

Biological Process: phospholipid metabolic process; phosphatidylinositol biosynthetic process; insulin receptor signaling pathway; regulation of phosphoinositide 3-kinase activity
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Research Articles on PIK3R3

1. Containing the N24 of PI3K-p55PIK.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-PIK3R3 antibody

 Reference Product  PubMed Publications
 PIK3CG antibody  >4 publications with PIK3R3 and PIK3CG
 PIK3CB antibody  >3 publications with PIK3R3 and PIK3CB
 PIK3CA antibody  >3 publications with PIK3R3 and PIK3CA
 PTEN antibody  >1 publications with PIK3R3 and PTEN
 IRS1 antibody  >1 publications with PIK3R3 and IRS1
 IGF1R antibody  >1 publications with PIK3R3 and IGF1R

Pathways associated with anti-PIK3R3 antibody

 Products by Pathway  Pathway Diagram
 3-phosphoinositide Biosynthesis Pathway antibodies  3-phosphoinositide Biosynthesis Pathway Diagram
 3-phosphoinositide Biosynthesis Pathway antibodies  3-phosphoinositide Biosynthesis Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 Acute Myeloid Leukemia Pathway antibodies  Acute Myeloid Leukemia Pathway Diagram
 Acute Myeloid Leukemia Pathway antibodies  Acute Myeloid Leukemia Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Adrenergic Signaling In Cardiomyocytes Pathway antibodies  Adrenergic Signaling In Cardiomyocytes Pathway Diagram
 Adrenergic Signaling In Cardiomyocytes Pathway antibodies  Adrenergic Signaling In Cardiomyocytes Pathway Diagram

Diseases associated with anti-PIK3R3 antibody

 Disease Name  Pubmed Publications
 Neoplasms, Experimental Antibodies  >2 publications with PIK3R3 and Neoplasms, Experimental
 Brain Diseases Antibodies  >2 publications with PIK3R3 and Brain Diseases
 Adenocarcinoma Antibodies  >2 publications with PIK3R3 and Adenocarcinoma
 Breast Neoplasms Antibodies  >2 publications with PIK3R3 and Breast Neoplasms
 Inflammation Antibodies  >2 publications with PIK3R3 and Inflammation
 Nervous System Diseases Antibodies  >2 publications with PIK3R3 and Nervous System Diseases
 Cardiovascular Diseases Antibodies  >1 publications with PIK3R3 and Cardiovascular Diseases
 Disease Models, Animal Antibodies  >1 publications with PIK3R3 and Disease Models, Animal
 Fatty Liver Antibodies  >1 publications with PIK3R3 and Fatty Liver
 Necrosis Antibodies  >1 publications with PIK3R3 and Necrosis

Organs/Tissues associated with anti-PIK3R3 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >6 publications with PIK3R3 and Blood
 Lung Antibodies  >6 publications with PIK3R3 and Lung
 Vascular Antibodies  >4 publications with PIK3R3 and Vascular
 Prostate Antibodies  >3 publications with PIK3R3 and Prostate
 Liver Antibodies  >3 publications with PIK3R3 and Liver
 Heart Antibodies  >2 publications with PIK3R3 and Heart
 Stomach Antibodies  >2 publications with PIK3R3 and Stomach
 Muscle Antibodies  >2 publications with PIK3R3 and Muscle
 Brain Antibodies  >2 publications with PIK3R3 and Brain
 Thyroid Antibodies  >1 publications with PIK3R3 and Thyroid
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