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PRKCSH Antibody – Rabbit

For Research Use Only. Not for use in diagnostic procedures. Special Promotion Catalog #: MBS129102
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This gene encodes the beta-subunit of glucosidase II, an N-linked glycan-processing enzyme in the endoplasmic reticulum. The encoded protein is an acidic phosphoprotein known to be a substrate for protein kinase C. Mutations in this gene have been associated… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
PRKCSH, Antibody
Full Product Name
PRKCSH Polyclonal Antibody
Product Gene Name
anti-PRKCSH antibody
Product Synonym Names
PRKCSH; AGE-R2; G19P1; GIIB; PCLD; PCLD1; PLD1; VASAP-60
Isotype
IgG
Host
Rabbit
Form/Format
PBS with 0.02% sodium azide, pH 7.3
Purity/Purification
Affinity purification
Preparation and Storage
Store at 4°C. Avoid freeze/thaw cycles.
Molecular Weight
Observed MW: 80 kDa
Calculated MW: 59 kDa
OMIM
phenotype 177060
3D Structure
ModBase 3D Structure for P14314
Species Reactivity/Cross-Reactivity
Human, Mouse, Rat
Immunogen
A synthetic peptide of human PRKCSH
Category
Primary Antibody

Product Categories/Family for anti-PRKCSH antibody

Polyclonal
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-PRKCSH antibody
Western Blot (WB)
Application Notes for anti-PRKCSH antibody
WB: 1:500-1:1:1000

Western Blot (WB) of anti-PRKCSH antibody

Western blot analysis of extracts of various cell lines, using PRKCSH antibody MBS129102 at 1:1000 dilution.
Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (MBS128200) at 1:10000 dilution.
Lysates/proteins: 25ug per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Detection: ECL Basic Kit (RM00020).
Exposure Time: 5s.
Rabbit Anti-PRKCSH Antibody – Cat# MBS129102

Western Blot (WB) of anti-PRKCSH antibody

Western blot analysis of extracts of Mouse Lung, using PRKCSH antibody MBS129102 at 1:1000 dilution.
Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (MBS128200) at 1:10000 dilution.
Lysates/proteins: 25ug per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Detection: ECL Basic Kit (RM00020).
Exposure Time: 60s.
Rabbit Anti-PRKCSH Antibody, Western Blot (WB) – Cat# MBS129102

Other Notes

Small volumes of anti-PRKCSH antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PRKCSH purchase

MBS129102 is an antibody targeting PRKCSH. Also known as PRKCSH Polyclonal Antibody. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for PRKCSH. It may not necessarily be applicable to this product.

NCBI GI #
116242499
NCBI GeneID
5589
NCBI Accession #
P14314.2
UniProt Primary Accession #
P14314
UniProt Secondary Accession #
Q96BU9; Q96D06; Q9P0W9; A8K318
UniProt Related Accession #
P14314
NCBI Official Full Name
Glucosidase 2 subunit beta
NCBI Official Synonym Full Names
protein kinase C substrate 80K-H
NCBI Official Symbol
PRKCSH
NCBI Official Synonym Symbols
PCLD; PLD1; G19P1; PKCSH; AGE-R2
UniProt Protein Name
Glucosidase 2 subunit beta
UniProt Synonym Protein Names
80K-H protein; Glucosidase II subunit beta; Protein kinase C substrate 60.1 kDa protein heavy chain; PKCSH
Protein Family
Glucosidase
UniProt Gene Name
PRKCSH
UniProt Synonym Gene Names
G19P1; PKCSH
UniProt Entry Name
GLU2B_HUMAN
NCBI Protein Information
glucosidase 2 subunit beta; hepatocystin; AGE-binding receptor 2; glucosidase II subunit beta; protein kinase C substrate, 80 Kda protein; protein kinase C substrate 60.1 kDa protein heavy chain

UniProt Comments for PRKCSH

PRKCSH: Regulatory subunit of glucosidase II. Defects in PRKCSH are a cause of polycystic liver disease (PCLD). PCLD is an autosomal dominant disorder and is characterized by the presence of multiple liver cysts of biliary epithelial origin. PCLD is a distinct clinical and genetic entity that can occur independently from autosomal dominant polycystic kidney disease (ADPKD), which in a considerable but uncertain proportion of cases is associated with hepatic cysts. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: 19p13.2

Cellular Component: endoplasmic reticulum; endoplasmic reticulum lumen; intracellular

Molecular Function: protein kinase C binding; phosphoprotein binding; calcium ion binding

Biological Process: cellular protein metabolic process; protein folding; innate immune response; protein amino acid N-linked glycosylation via asparagine; N-glycan processing; post-translational protein modification

Disease: Polycystic Liver Disease
Show more

Research Articles on PRKCSH

1. Polycystic liver disease is recessive at the cellular level, and loss of functional PRKCSH is an important step in cystogenesis.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-PRKCSH antibody

 Reference Product  PubMed Publications
 SEC63 antibody  >22 publications with PRKCSH and SEC63
 PKD1 antibody  >6 publications with PRKCSH and PKD1
 LGALS3 antibody  >2 publications with PRKCSH and LGALS3
 DDOST antibody  >1 publications with PRKCSH and DDOST

Pathways associated with anti-PRKCSH antibody

 Products by Pathway  Pathway Diagram
 Advanced Glycosylation Endproduct Receptor Signaling Pathway antibodies  Advanced Glycosylation Endproduct Receptor Signaling Pathway Diagram
 Asparagine N-linked Glycosylation Pathway antibodies  Asparagine N-linked Glycosylation Pathway Diagram
 Calnexin/calreticulin Cycle Pathway antibodies  Calnexin/calreticulin Cycle Pathway Diagram
 Defective ALG1 Causes ALG1-CDG (CDG-1k) Pathway antibodies  Defective ALG1 Causes ALG1-CDG (CDG-1k) Pathway Diagram
 Defective ALG11 Causes ALG11-CDG (CDG-1p) Pathway antibodies  Defective ALG11 Causes ALG11-CDG (CDG-1p) Pathway Diagram
 Defective ALG12 Causes ALG12-CDG (CDG-1g) Pathway antibodies  Defective ALG12 Causes ALG12-CDG (CDG-1g) Pathway Diagram
 Defective ALG14 Causes Congenital Myasthenic Syndrome (ALG14-CMS) Pathway antibodies  Defective ALG14 Causes Congenital Myasthenic Syndrome (ALG14-CMS) Pathway Diagram
 Defective ALG2 Causes ALG2-CDG (CDG-1i) Pathway antibodies  Defective ALG2 Causes ALG2-CDG (CDG-1i) Pathway Diagram
 Defective ALG3 Causes ALG3-CDG (CDG-1d) Pathway antibodies  Defective ALG3 Causes ALG3-CDG (CDG-1d) Pathway Diagram
 Defective ALG6 Causes ALG6-CDG (CDG-1c) Pathway antibodies  Defective ALG6 Causes ALG6-CDG (CDG-1c) Pathway Diagram

Diseases associated with anti-PRKCSH antibody

 Disease Name  Pubmed Publications
 Polycystic liver disease Antibodies  >36 publications with PRKCSH and Polycystic liver disease
 Kidney Diseases Antibodies  >26 publications with PRKCSH and Kidney Diseases
 Polycystic Kidney Diseases Antibodies  >25 publications with PRKCSH and Polycystic Kidney Diseases
 Hypertension Antibodies  >4 publications with PRKCSH and Hypertension
 Cardiovascular Diseases Antibodies  >3 publications with PRKCSH and Cardiovascular Diseases
 Liver Neoplasms Antibodies  >2 publications with PRKCSH and Liver Neoplasms
 Heart Diseases Antibodies  >2 publications with PRKCSH and Heart Diseases
 Nervous System Diseases Antibodies  >2 publications with PRKCSH and Nervous System Diseases
 Carcinoma, Hepatocellular Antibodies  >2 publications with PRKCSH and Carcinoma, Hepatocellular
 Brain Diseases Antibodies  >2 publications with PRKCSH and Brain Diseases

Organs/Tissues associated with anti-PRKCSH antibody

 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >39 publications with PRKCSH and Liver
 Kidney Antibodies  >30 publications with PRKCSH and Kidney
 Brain Antibodies  >12 publications with PRKCSH and Brain
 Blood Antibodies  >8 publications with PRKCSH and Blood
 Muscle Antibodies  >5 publications with PRKCSH and Muscle
 Nerve Antibodies  >4 publications with PRKCSH and Nerve
 Parathyroid Antibodies  >3 publications with PRKCSH and Parathyroid
 Vascular Antibodies  >2 publications with PRKCSH and Vascular
 Embryonic Tissue Antibodies  >2 publications with PRKCSH and Embryonic Tissue
 Ovary Antibodies  >2 publications with PRKCSH and Ovary
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