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TLR4 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Special Promotion Catalog #: MBS129143
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The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
TLR4, Polyclonal Antibody
Full Product Name
TLR4
Product Gene Name
anti-TLR4 antibody
Product Synonym Names
TLR4;ARMD10;CD284;TLR-4;TOLL
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Form/Format
PBS with 0.02% sodium azide, 50% glycerol, pH 7.3.
Purity/Purification
Affinity Purification
Preparation and Storage
Store at -20°C. Avoid freeze/thaw cycles.
Molecular Weight
Observed MW: 98KDa
Calculated MW: 73kDa/91kDa/95kDa
Chromosome Location
Chromosome: 9; NC_000009.11 (120466453..120479769). Location: 9q33.1
OMIM
603030
3D Structure
ModBase 3D Structure for O00206
Immunogen
A synthetic peptide corresponding to a sequence within the amino acids 500-600 of human TLR4 (NP_612564.1).
Species Reactivity/Cross-Reactivity
Human, Mouse, Rat
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-TLR4 antibody
Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
Application Notes for anti-TLR4 antibody
Recommended Dilutions:
WB: 1:500-1:2000
IF: 1:50-1:200

Western Blot (WB) of anti-TLR4 antibody

Western blot analysis of extracts of A-549 cells, using TLR4 antibody (MBS129143) at 1:1000 dilution.
Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (MBS128200) at 1:10000 dilution.
Lysates/proteins: 25ug per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Detection: ECL Enhanced Kit.
Exposure time: 5min.
Rabbit Anti-TLR4 Polyclonal Antibody – Cat# MBS129143

Immunohistochemistry (IHC) of anti-TLR4 antibody

Immunohistochemistry of paraffin-embedded rat spleen using TLR4 antibody (MBS129143) at dilution of 1:100 (40x lens).
Rabbit Anti-TLR4 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS129143

Immunohistochemistry (IHC) of anti-TLR4 antibody

Immunohistochemistry of paraffin-embedded mouse spleen using TLR4 antibody (MBS129143) at dilution of 1:100 (40x lens).
Rabbit Anti-TLR4 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS129143

Immunofluorescence (IF) of anti-TLR4 antibody

Immunofluorescence analysis of HeLa cells using TLR4 antibody (MBS129143) at dilution of 1:100. Blue: DAPI for nuclear staining.
Rabbit Anti-TLR4 Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS129143

Immunofluorescence (IF) of anti-TLR4 antibody

Immunofluorescence analysis of HeLa cells using TLR4 Rabbit pAb (MBS129143) at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining.
Rabbit Anti-TLR4 Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS129143

Immunofluorescence (IF) of anti-TLR4 antibody

Immunofluorescence analysis of THP-1 cells using TLR4 Rabbit pAb (MBS129143) at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining.
Rabbit Anti-TLR4 Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS129143

Other Notes

Small volumes of anti-TLR4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TLR4 purchase

MBS129143 is an antibody targeting TLR4. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for TLR4. It may not necessarily be applicable to this product.

NCBI GI #
4507533
NCBI GeneID
7099
NCBI Accession #
NP_003257.1
UniProt Primary Accession #
O00206
UniProt Secondary Accession #
Q5VZI8; Q5VZI9; Q9UK78; Q9UM57; A8K1Y8; A9XLP9; A9XLQ0; A9XLQ1; B4E194; D1CS52; D1CS53
UniProt Related Accession #
O00206
GenBank Nucleotide #
NM_003266.3
NCBI Official Full Name
toll-like receptor 4 isoform C
NCBI Official Synonym Full Names
toll-like receptor 4
NCBI Official Symbol
TLR4
NCBI Official Synonym Symbols
TOLL; CD284; TLR-4; ARMD10
UniProt Protein Name
Toll-like receptor 4
UniProt Synonym Protein Names
hToll
Protein Family
Toll-like receptor
UniProt Gene Name
TLR4
UniProt Entry Name
TLR4_HUMAN
NCBI Protein Information
toll-like receptor 4; hToll; homolog of Drosophila toll

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-TLR4 antibody

 Products by Pathway  Pathway Diagram
 Activated TLR4 Signalling Pathway antibodies  Activated TLR4 Signalling Pathway Diagram
 Activation Of IRF3/IRF7 Mediated By TBK1/IKK Epsilon Pathway antibodies  Activation Of IRF3/IRF7 Mediated By TBK1/IKK Epsilon Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Chagas Disease (American Trypanosomiasis) Pathway antibodies  Chagas Disease (American Trypanosomiasis) Pathway Diagram
 Chagas Disease (American Trypanosomiasis) Pathway antibodies  Chagas Disease (American Trypanosomiasis) Pathway Diagram
 HIF-1 Signaling Pathway antibodies  HIF-1 Signaling Pathway Diagram
 Hepatitis B Pathway antibodies  Hepatitis B Pathway Diagram
 IKK Complex Recruitment Mediated By RIP1 Pathway antibodies  IKK Complex Recruitment Mediated By RIP1 Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram

Diseases associated with anti-TLR4 antibody

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >3097 publications with TLR4 and Inflammation
 Necrosis Antibodies  >2154 publications with TLR4 and Necrosis
 Sepsis Antibodies  >678 publications with TLR4 and Sepsis
 Neoplasms Antibodies  >496 publications with TLR4 and Neoplasms
 Liver Diseases Antibodies  >357 publications with TLR4 and Liver Diseases
 Atherosclerosis Antibodies  >343 publications with TLR4 and Atherosclerosis
 Drug Toxicity Antibodies  >332 publications with TLR4 and Drug Toxicity
 Heart Diseases Antibodies  >219 publications with TLR4 and Heart Diseases
 Fibrosis Antibodies  >175 publications with TLR4 and Fibrosis
 Carcinoma Antibodies  >170 publications with TLR4 and Carcinoma

Organs/Tissues associated with anti-TLR4 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >3292 publications with TLR4 and Blood
 Lung Antibodies  >805 publications with TLR4 and Lung
 Liver Antibodies  >729 publications with TLR4 and Liver
 Bone Antibodies  >723 publications with TLR4 and Bone
 Bone Marrow Antibodies  >616 publications with TLR4 and Bone Marrow
 Vascular Antibodies  >504 publications with TLR4 and Vascular
 Intestine Antibodies  >457 publications with TLR4 and Intestine
 Brain Antibodies  >447 publications with TLR4 and Brain
 Spleen Antibodies  >365 publications with TLR4 and Spleen
 Kidney Antibodies  >353 publications with TLR4 and Kidney
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