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N-Lysine Methyltransferase SETD8 (SETD8) Bovine Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1292641

MBS1292641 is a recombinant protein targeting SETD8. Also known as Recombinant Bovine N-lysine methyltransferase SETD8 (SETD8). Host: E Coli or Yeast or Baculovirus or Mammalian Cell. More details

$1070 / 0.02 mg (E-Coli) +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
N-lysine methyltransferase SETD8 (SETD8), Recombinant Protein
Full Product Name
Recombinant Bovine N-lysine methyltransferase SETD8 (SETD8)
Product Gene Name
SETD8 recombinant protein
Product Synonym Gene Name
SETD8
Sequence
MARGRKMSKP RAVEAAAAAA AVAATAPGPE MVERRGPGRP RTNGENVFTG QSKIYTYMSP NKCSGMRSPL QEENSVAQYE VKCQGKPLAG IYRKRDEKRN SGNAIRSSMK AEEQKIKDAR RGPLAPFPNQ KSEAAEPPKT PTSSCDTPNA AAAKQGLKKP VRGKQAPRKK AQGKTQQNRK LTDFYPVRRS SRKSKAELQS EERKRIDELI ESGKEEGMKI DLIDGKGRGV IATKQFSRGE FVVEYHGDLI EITDAKKREA LYAQDPSTGC YMYYFQYLSK TYCVDATRET NRLGRLINHS KCGNCQTKLH DIDGVPHLIL IASRDIEAGE ELLYDYGDRS RASIEAYPWL KH
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Molecular Weight
39,277 Da
Sequence Positions
1-352, full length protein
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
3D Structure
ModBase 3D Structure for Q2YDJ8
Species
Bovine
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of SETD8 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for SETD8. It may not necessarily be applicable to this product.

NCBI GI #
114053187
NCBI GeneID
532622
NCBI Accession #
NP_001039795.1
UniProt Primary Accession #
Q2YDJ8
UniProt Related Accession #
Q2YDJ8
GenBank Nucleotide #
NM_001046330.1
NCBI Official Full Name
N-lysine methyltransferase KMT5A
NCBI Official Symbol
KMT5A
NCBI Official Synonym Symbols
SETD8
UniProt Protein Name
N-lysine methyltransferase KMT5A
UniProt Synonym Protein Names
H4-K20-HMTase KMT5A; Histone-lysine N-methyltransferase KMT5A (EC:2.1.1.43); Lysine-specific methylase 5A
UniProt Gene Name
KMT5A
UniProt Synonym Gene Names
PR-Set7; PR/SET07
NCBI Protein Information
N-lysine methyltransferase KMT5A

UniProt Comments for SETD8

Protein-lysine N-methyltransferase that monomethylates both histones and non-histone proteins. Specifically monomethylates 'Lys-20' of histone H4 (H4K20me1). H4K20me1 is enriched during mitosis and represents a specific tag for epigenetic transcriptional repression. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. Required for cell proliferation, probably by contributing to the maintenance of proper higher-order structure of DNA during mitosis. Involved in chromosome condensation and proper cytokinesis. Nucleosomes are preferred as substrate compared to free histones. Mediates monomethylation of p53/TP53 at 'Lys-382', leading to repress p53/TP53-target genes. Plays a negative role in TGF-beta response regulation and a positive role in cell migration ().
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with SETD8 recombinant protein

 Reference Product  PubMed Publications
 PCNA recombinant protein  >10 publications with SETD8 and PCNA
 TP53 recombinant protein  >6 publications with SETD8 and TP53
 SETD7 recombinant protein  >2 publications with SETD8 and SETD7

Pathways associated with SETD8 recombinant protein

 Products by Pathway  Pathway Diagram
 Lysine Degradation Pathway antibodies  Lysine Degradation Pathway Diagram
 Lysine Degradation Pathway antibodies  Lysine Degradation Pathway Diagram

Diseases associated with SETD8 recombinant protein

 Disease Name  Pubmed Publications
 Skin Diseases Antibodies  >4 publications with SETD8 and Skin Diseases
 Fetal Growth Retardation Antibodies  >1 publications with SETD8 and Fetal Growth Retardation
 Liver Neoplasms Antibodies  >1 publications with SETD8 and Liver Neoplasms
 Liver Diseases Antibodies  >1 publications with SETD8 and Liver Diseases
 Carcinoma, Hepatocellular Antibodies  >1 publications with SETD8 and Carcinoma, Hepatocellular

Organs/Tissues associated with SETD8 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >3 publications with SETD8 and Brain
 Liver Antibodies  >3 publications with SETD8 and Liver
 Skin Antibodies  >2 publications with SETD8 and Skin
 Intestine Antibodies  >2 publications with SETD8 and Intestine
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