GRIN2A Antibody – Rabbit Polyclonal

NMDAR2A: a subunit of N-methyl-D-aspartate (NMDA) receptors, members of the glutamate receptor channel superfamily. Possesses high calcium permeability and voltage-dependent sensitivity to magnesium and is modulated by glycine. Plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. Mediates neuronal functions in glutamate neurotransmission.

Protein type: Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 16p13.2

Cellular Component: presynaptic membrane; postsynaptic membrane; synaptic vesicle; cell surface; integral to plasma membrane; endoplasmic reticulum; dendrite; plasma membrane; cell junction; N-methyl-D-aspartate selective glutamate receptor complex

Molecular Function: protein binding; extracellular-glutamate-gated ion channel activity; zinc ion binding; N-methyl-D-aspartate selective glutamate receptor activity; calcium channel activity

Biological Process: response to drug; synaptic transmission, glutamatergic; startle response; positive regulation of apoptosis; glutamate signaling pathway; response to amphetamine; regulation of synaptic plasticity; sleep; sensory perception of pain; dopamine metabolic process; memory; synaptic transmission; protein localization; response to ethanol; learning and/or memory; neurogenesis; directional locomotion; transport; ionotropic glutamate receptor signaling pathway; response to wounding; visual learning; regulation of sensory perception of pain; negative regulation of protein catabolic process; regulation of excitatory postsynaptic membrane potential; serotonin metabolic process

Disease: Epilepsy, Focal, With Speech Disorder And With Or Without Mental Retardation