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PSMC3 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Special Promotion Catalog #: MBS129431
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The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2… More details

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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
PSMC3, Polyclonal Antibody
Full Product Name
PSMC3 Polyclonal Antibody
Product Gene Name
anti-PSMC3 antibody
Product Synonym Names
TBP1
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Purity/Purification
Affinity Purification
Concentration
1mg/ml (lot specific)
Preparation and Storage
Store at -20 degree C (regular) or -80 degree C (long term). Avoid freeze / thaw cycles.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Molecular Weight
439
OMIM
186852
3D Structure
ModBase 3D Structure for P17980
Species
Human
Immunogen
Recombinant protein of human PSMC3
Calculated Molecular Weight
49kDa

Product Categories/Family for anti-PSMC3 antibody

Polyclonal
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-PSMC3 antibody
Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
Application Notes for anti-PSMC3 antibody
WB: 1:500 - 1:2000
IHC: 1:50 - 1:200
IF: 1:50 - 1:200

Western Blot (WB) of anti-PSMC3 antibody

Western blot analysis of extracts of various cell lines, using PSMC3 antibody at 1:1000 dilution.
Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (MBS128200) at 1:10000 dilution.
Lysates/proteins: 25ug per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Rabbit Anti-PSMC3 Polyclonal Antibody – Cat# MBS129431

Immunohistochemistry (IHC) of anti-PSMC3 antibody

Immunohistochemistry of paraffin-embedded rat intestine using PSMC3 Antibody at dilution of 1:200 (40x lens).
Rabbit Anti-PSMC3 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS129431

Immunohistochemistry (IHC) of anti-PSMC3 antibody

Immunohistochemistry of paraffin-embedded rat liver using PSMC3 Antibody at dilution of 1:100 (40x lens).
Rabbit Anti-PSMC3 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS129431

Immunohistochemistry (IHC) of anti-PSMC3 antibody

Immunohistochemistry of paraffin-embedded rat kidney using PSMC3 Antibody at dilution of 1:100 (40x lens).
Rabbit Anti-PSMC3 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS129431

Immunofluorescence (IF) of anti-PSMC3 antibody

Immunofluorescence analysis of MCF-7 cells using PSMC3 antibody.
Rabbit Anti-PSMC3 Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS129431

Other Notes

Small volumes of anti-PSMC3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PSMC3 purchase

MBS129431 is an antibody targeting PSMC3. Also known as PSMC3 Polyclonal Antibody. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for PSMC3. It may not necessarily be applicable to this product.

NCBI GI #
20532406
NCBI GeneID
5702
NCBI Accession #
P17980.3
UniProt Primary Accession #
P17980
UniProt Secondary Accession #
Q3B757; Q3B865; Q53HU5; Q6GPG8; Q6IBS1; Q96HD3; B2R8V1
UniProt Related Accession #
P17980
NCBI Official Full Name
26S protease regulatory subunit 6A
NCBI Official Synonym Full Names
proteasome (prosome, macropain) 26S subunit, ATPase, 3
NCBI Official Symbol
PSMC3
NCBI Official Synonym Symbols
TBP1
UniProt Protein Name
26S protease regulatory subunit 6A
UniProt Synonym Protein Names
26S proteasome AAA-ATPase subunit RPT5; Proteasome 26S subunit ATPase 3; Proteasome subunit P50; Tat-binding protein 1; TBP-1
Protein Family
26S protease regulatory
UniProt Gene Name
PSMC3
UniProt Synonym Gene Names
TBP1; TBP-1
UniProt Entry Name
PRS6A_HUMAN
NCBI Protein Information
26S protease regulatory subunit 6A; TBP-1; Tat-binding protein 1; proteasome subunit P50; proteasome 26S subunit ATPase 3; 26S proteasome AAA-ATPase subunit RPT5; human immunodeficiency virus tat transactivator binding protein-1

UniProt Comments for PSMC3

RPT5: The 26S protease is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex. In case of HIV-1 infection, suppresses Tat-mediated transactivation. Belongs to the AAA ATPase family.

Protein type: Proteasome complex; Transcription, coactivator/corepressor; Nuclear receptor co-regulator

Chromosomal Location of Human Ortholog: 11p11.2

Cellular Component: proteasome complex; nucleoplasm; membrane; perinuclear region of cytoplasm; nucleus; cytosol

Molecular Function: protein binding; ATPase activity; transcription coactivator activity; transcription corepressor activity; ATP binding

Biological Process: positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle; negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle; blastocyst development; protein polyubiquitination; viral reproduction; apoptosis; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; regulation of apoptosis; antigen processing and presentation of peptide antigen via MHC class I; regulation of ubiquitin-protein ligase activity during mitotic cell cycle; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; antigen processing and presentation of exogenous peptide antigen via MHC class I; gene expression; mitotic cell cycle; regulation of amino acid metabolic process; G1/S transition of mitotic cell cycle; negative regulation of apoptosis
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Research Articles on PSMC3

1. These data suggest the existence of a negative feedback loop involving Akt/PKB that might act as a sensor to modulate TBP-1 levels in proliferating cells.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-PSMC3 antibody

 Reference Product  PubMed Publications
 PSMC2 antibody  >3 publications with PSMC3 and PSMC2
 PSMC4 antibody  >2 publications with PSMC3 and PSMC4
 PSMC5 antibody  >2 publications with PSMC3 and PSMC5
 PSMD9 antibody  >1 publications with PSMC3 and PSMD9
 PSMC1 antibody  >1 publications with PSMC3 and PSMC1

Pathways associated with anti-PSMC3 antibody

 Products by Pathway  Pathway Diagram
 AMER1 Mutants Destabilize The Destruction Complex Pathway antibodies  AMER1 Mutants Destabilize The Destruction Complex Pathway Diagram
 APC Truncation Mutants Are Not K63 Polyubiquitinated Pathway antibodies  APC Truncation Mutants Are Not K63 Polyubiquitinated Pathway Diagram
 APC Truncation Mutants Have Impaired AXIN Binding Pathway antibodies  APC Truncation Mutants Have Impaired AXIN Binding Pathway Diagram
 APC/C-mediated Degradation Of Cell Cycle Proteins Pathway antibodies  APC/C-mediated Degradation Of Cell Cycle Proteins Pathway Diagram
 APC/C:Cdc20 Mediated Degradation Of Securin Pathway antibodies  APC/C:Cdc20 Mediated Degradation Of Securin Pathway Diagram
 APC/C:Cdc20 Mediated Degradation Of Mitotic Proteins Pathway antibodies  APC/C:Cdc20 Mediated Degradation Of Mitotic Proteins Pathway Diagram
 APC/C:Cdh1 Mediated Degradation Of Cdc20 And Other APC/C:Cdh1 Targeted Proteins In Late Mitosis/early G1 Pathway antibodies  APC/C:Cdh1 Mediated Degradation Of Cdc20 And Other APC/C:Cdh1 Targeted Proteins In Late Mitosis/early G1 Pathway Diagram
 APC:Cdc20 Mediated Degradation Of Cell Cycle Proteins Prior To Satisfation Of The Cell Cycle Checkpoint Pathway antibodies  APC:Cdc20 Mediated Degradation Of Cell Cycle Proteins Prior To Satisfation Of The Cell Cycle Checkpoint Pathway Diagram
 AUF1 (hnRNP D0) Destabilizes MRNA Pathway antibodies  AUF1 (hnRNP D0) Destabilizes MRNA Pathway Diagram
 AXIN Missense Mutants Destabilize The Destruction Complex Pathway antibodies  AXIN Missense Mutants Destabilize The Destruction Complex Pathway Diagram

Diseases associated with anti-PSMC3 antibody

 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >4 publications with PSMC3 and Nervous System Diseases
 Brain Diseases Antibodies  >4 publications with PSMC3 and Brain Diseases
 Immune System Diseases Antibodies  >3 publications with PSMC3 and Immune System Diseases
 Necrosis Antibodies  >3 publications with PSMC3 and Necrosis
 HIV Infections Antibodies  >3 publications with PSMC3 and HIV Infections
 Infertility, Male Antibodies  >1 publications with PSMC3 and Infertility, Male
 Prostatic Diseases Antibodies  >1 publications with PSMC3 and Prostatic Diseases
 Carcinoma, Hepatocellular Antibodies  >1 publications with PSMC3 and Carcinoma, Hepatocellular
 Kidney Diseases Antibodies  >1 publications with PSMC3 and Kidney Diseases

Organs/Tissues associated with anti-PSMC3 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >8 publications with PSMC3 and Brain
 Testis Antibodies  >7 publications with PSMC3 and Testis
 Blood Antibodies  >5 publications with PSMC3 and Blood
 Thyroid Antibodies  >4 publications with PSMC3 and Thyroid
 Muscle Antibodies  >2 publications with PSMC3 and Muscle
 Stomach Antibodies  >1 publications with PSMC3 and Stomach
 Bladder Antibodies  >1 publications with PSMC3 and Bladder
 Ovary Antibodies  >1 publications with PSMC3 and Ovary
 Uterus Antibodies  >1 publications with PSMC3 and Uterus
 Kidney Antibodies  >1 publications with PSMC3 and Kidney
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