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PHB2 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Special Promotion Catalog #: MBS129441
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Background: Protein with pleiotropic attributes mediated in a cell-compartment- and tissue-specific manner, which include the plasma membrane-associated cell signaling functions, mitochondrial chaperone, and transcriptional co-regulator of transcription… More details

$225 / 0.02 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
PHB2, Polyclonal Antibody
Full Product Name
PHB2 Polyclonal Antibody
Product Gene Name
anti-PHB2 antibody
Product Synonym Names
PHB2;BAP;BCAP37;Bap37;PNAS-141;REA;hBAP;p22
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Form/Format
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Purity/Purification
Affinity Purification
Concentration
1mg/ml (lot specific)
Preparation and Storage
Store at -20 degree C (regular) or -80 degree C (long term). Avoid freeze / thaw cycles.
Molecular Weight
Observed MW: 32kDa
Calculated MW: 29kDa/33kDa
OMIM
610704
3D Structure
ModBase 3D Structure for Q99623
Species
Human
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1-299 of human Prohibitin 2 (Prohibitin 2 (PHB2)) (NP_001138303.1).
Cross-Reactivity
Human, Mouse, Rat

Product Categories/Family for anti-PHB2 antibody

Polyclonal
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-PHB2 antibody
Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP)
Application Notes for anti-PHB2 antibody
WB 1:500 - 1:2000
IHC 1:50 - 1:100
IF 1:50 - 1:100
IP 1:50 - 1:200

Western Blot (WB) of anti-PHB2 antibody

Western blot analysis of extracts of various cell lines, using PHB2 antibody at 1:1000 dilution.
Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (MBS128200) at 1:10000 dilution.
Lysates/proteins: 25ug per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Detection: ECL Basic Kit.
Exposure time: 90s.
Rabbit Anti-PHB2 Polyclonal Antibody – Cat# MBS129441

Immuoprecipitation (IP) of anti-PHB2 antibody

mmunoprecipitation analysis of 300ug extracts of A-549 cells using 3ug Prohibitin 2 (PHB2) antibody(MBS129441). Western blot was performed from the immunoprecipitate using Prohibitin 2 (PHB2) antibody (MBS129441) at a dilition of 1:1000
Rabbit Anti-PHB2 Polyclonal Antibody, Immuoprecipitation (IP) – Cat# MBS129441

Immunohistochemistry (IHC) of anti-PHB2 antibody

Immunohistochemistry of paraffin-embedded human esophagus using PHB2 antibody at dilution of 1:100 (40x lens).
Rabbit Anti-PHB2 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS129441

Other Notes

Small volumes of anti-PHB2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PHB2 purchase

MBS129441 is an antibody targeting PHB2. Also known as PHB2 Polyclonal Antibody. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for PHB2. It may not necessarily be applicable to this product.

NCBI GI #
74752151
NCBI GeneID
11331
NCBI Accession #
Q99623.2
UniProt Primary Accession #
Q99623
UniProt Secondary Accession #
Q2YDA4; Q7KYU3; Q92978; B4DP75
UniProt Related Accession #
Q99623
NCBI Official Full Name
Prohibitin-2
NCBI Official Synonym Full Names
prohibitin 2
NCBI Official Symbol
PHB2
NCBI Official Synonym Symbols
BAP; REA; p22; Bap37; BCAP37; PNAS-141
UniProt Protein Name
Prohibitin-2
UniProt Synonym Protein Names
B-cell receptor-associated protein BAP37; D-prohibitin; Repressor of estrogen receptor activity
Protein Family
Prohibitin
UniProt Gene Name
PHB2
UniProt Entry Name
PHB2_HUMAN
NCBI Protein Information
prohibitin-2; PHB2; D-prohibitin; B-cell associated protein; repressor of estrogen receptor activity; B-cell receptor-associated protein BAP37

UniProt Comments for PHB2

BAP37: a protein of the band 7 family. This family includes the prohibitins, cytoplasmic anti-proliferative proteins and stomatin, an erythrocyte membrane protein. A repressor of estrogen receptor (ER) activity. Reverses steroid receptor coactivator 1 enhancement of ER activity. May play a role in determining the sensitivity of estrogen target cells to antiestrogen and estrogen therapy.

Protein type: Mitochondrial; Nuclear receptor co-regulator; Transcription, coactivator/corepressor

Chromosomal Location of Human Ortholog: 12p13

Cellular Component: protein complex; nuclear matrix; mitochondrion; mitochondrial inner membrane; nucleus

Molecular Function: protein binding; estrogen receptor binding

Biological Process: transcription, DNA-dependent; negative regulation of transcription, DNA-dependent; negative regulation of mammary gland epithelial cell proliferation; negative regulation of estrogen receptor signaling pathway
Show more

Research Articles on PHB2

1. PHB2 in hepatocellular carcinoma supports the development and progression of hepatocellular malignancy.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-PHB2 antibody

 Reference Product  PubMed Publications
 PHB antibody  >22 publications with PHB2 and PHB
 ESR1 antibody  >3 publications with PHB2 and ESR1
 AKT1 antibody  >1 publications with PHB2 and AKT1

Diseases associated with anti-PHB2 antibody

 Disease Name  Pubmed Publications
 Weight Loss Antibodies  >4 publications with PHB2 and Weight Loss
 Liver Diseases Antibodies  >3 publications with PHB2 and Liver Diseases
 Breast Neoplasms Antibodies  >3 publications with PHB2 and Breast Neoplasms
 Inflammation Antibodies  >3 publications with PHB2 and Inflammation
 Carcinoma, Hepatocellular Antibodies  >2 publications with PHB2 and Carcinoma, Hepatocellular
 Atrophy Antibodies  >2 publications with PHB2 and Atrophy
 Liver Neoplasms Antibodies  >2 publications with PHB2 and Liver Neoplasms
 Neoplasms, Experimental Antibodies  >1 publications with PHB2 and Neoplasms, Experimental
 Precancerous Conditions Antibodies  >1 publications with PHB2 and Precancerous Conditions
 Hypertrophy Antibodies  >1 publications with PHB2 and Hypertrophy

Organs/Tissues associated with anti-PHB2 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >9 publications with PHB2 and Blood
 Muscle Antibodies  >7 publications with PHB2 and Muscle
 Liver Antibodies  >4 publications with PHB2 and Liver
 Heart Antibodies  >4 publications with PHB2 and Heart
 Brain Antibodies  >2 publications with PHB2 and Brain
 Prostate Antibodies  >1 publications with PHB2 and Prostate
 Ovary Antibodies  >1 publications with PHB2 and Ovary
 Uterus Antibodies  >1 publications with PHB2 and Uterus
 Intestine Antibodies  >1 publications with PHB2 and Intestine
 Uncharacterized Tissue Antibodies  >1 publications with PHB2 and Uncharacterized Tissue
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