CIT Antibody – Rabbit Polyclonal

CRIK: an AGC kinase that is a RHO/RAC effector. Binds to the GTP-bound forms of RHO and RAC1. Required for postnatal hippocampal neurogenesis. Rho/CRIK suppresses differentiation and is associated with induction of KyoT1/2, a LIM domain protein gene implicated in integrin-mediated processes and Notch signaling. Plays an important role in the regulation of cytokinesis and the development of the central nervous system. Overexpressed in mantle-cell lymphoma (MCL), an aggressive type of B-cell lymphoma. Three alternatively spliced isoforms have been described.

Protein type: Kinase, protein; EC 2.7.11.1; Protein kinase, Ser/Thr (non-receptor); Protein kinase, AGC; AGC group; DMPK family

Chromosomal Location of Human Ortholog: 12q24

Cellular Component: ruffle; Golgi cisterna; cell soma; membrane; plasma membrane; vacuole; actin cytoskeleton

Molecular Function: protein serine/threonine kinase activity; protein binding; Rho GTPase binding; metal ion binding; SH3 domain binding; ATP binding; PDZ domain binding

Biological Process: positive regulation of cytokinesis; mitosis; mitotic sister chromatid segregation; generation of neurons; regulation of catalytic activity; regulation of actin polymerization and/or depolymerization; dendrite development; cytokinesis; spermatogenesis; negative regulation of dendrite morphogenesis; G2/M transition of mitotic cell cycle; Golgi organization and biogenesis; protein amino acid phosphorylation; mitotic metaphase/anaphase transition