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BRCA1-A Complex Subunit RAP80 (UIMC1) Mouse Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1296309

MBS1296309 is a recombinant protein targeting Uimc1. Also known as Recombinant Mouse BRCA1-A complex subunit RAP80 (Uimc1). Host: E Coli or Yeast or Baculovirus or Mammalian Cell. More details

$1585 / 0.02 mg (E-Coli) +1 FREE 8GB USB
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
BRCA1-A complex subunit RAP80 (Uimc1), Recombinant Protein
Full Product Name
Recombinant Mouse BRCA1-A complex subunit RAP80 (Uimc1)
Product Gene Name
Uimc1 recombinant protein
Product Synonym Gene Name
Uimc1
Sequence
MPRRKKKIKE ASESQNLEKK DLETSSCVSI KKKRRLEDLL IVISDSDGEE TKEENGLQKT KTKQSNRSKC LAKRKVAHMS EEEQFALALK MSEQEAREVN NQEEKEEELL RKAIAESLNS CWSSAASATR SRPLAAELSS HSHQENTKDS GTTEGVWQLV PPSLCKGSHV SQGNEAEQRK EPWDHNENTE EEPVSGSSGS WDQSSQPVFE NENVKCFDRC TGHLAEHTQC GKPQESTGSG YAFSKAVQGR GDTSRQCLPI PADTKGLQDT GGTVHYYWGI PFCPAGVDPN QYTNVILCQL EVYQKSLKMA QRQLVKKRGF GEPVLPRPPF LIQNECGQED QTSDKNEGIS EDMGDEAKEE RQESRASVWH SETKDFQKSP IKSLKQKLLL EEEPTTSRGQ SSQGLFVEET SEEGLKSSEG DNSVPTTQSI AALTSKRSLV LMPESSAEEI TVCPETQLSF LEPLDLNRED SPDSRELPIE VRMAVGDKQV ANREDCMKEN PPPAVSSSTR VSCPLCNQDF PPTKIEQHAM YCNGLMEQET VLTRRRREAK NKSDGRTAAQ PALDANRKEK CYLCKSLVPL GEYQCHVEAC LQLAKVDRED GIEGTRRPRV CAPVEGKQQQ RLKKSKDKGH SQGRLLSLLE QSEHRTTGVE KKPKYSEVRT FRMPSPEVEE ASCSREMQST LSQLNLNESP IKSFVPVSEA TNCLVDFKEQ FAFRSRTKSG RGRRRKS
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Molecular Weight
50,382 Da
Sequence Positions
1-727, Full length protein
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
3D Structure
ModBase 3D Structure for Q5U5Q9
Species
Mouse
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of Uimc1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for Uimc1. It may not necessarily be applicable to this product.

NCBI GI #
652698318
NCBI GeneID
20184
NCBI Accession #
NP_001280589.1
UniProt Primary Accession #
Q5U5Q9
UniProt Secondary Accession #
Q3TU77; Q60811; Q8C3Z8; Q8C719; Q8K1X7
UniProt Related Accession #
Q5U5Q9
GenBank Nucleotide #
NM_001293660.1
NCBI Official Full Name
BRCA1-A complex subunit RAP80 isoform 2
NCBI Official Synonym Full Names
ubiquitin interaction motif containing 1
NCBI Official Symbol
Uimc1
NCBI Official Synonym Symbols
RIP110; Rxrip110; 9430016E08Rik; D330018D10Rik; D630032M02Rik
UniProt Protein Name
BRCA1-A complex subunit RAP80
UniProt Synonym Protein Names
Receptor-associated protein 80; Ubiquitin interaction motif-containing protein 1
Protein Family
BRCA1-A complex
UniProt Gene Name
Uimc1
UniProt Synonym Gene Names
Rap80; Rip110; Rxrip110
NCBI Protein Information
BRCA1-A complex subunit RAP80

UniProt Comments for Uimc1

Ubiquitin-binding protein. Specifically recognizes and binds 'Lys-63'-linked ubiquitin (PubMed:19536136). Plays a central role in the BRCA1-A complex by specifically binding 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. Also weakly binds monoubiquitin but with much less affinity than 'Lys-63'-linked ubiquitin. May interact with monoubiquitinated histones H2A and H2B; the relevance of such results is however unclear in vivo. Does not bind Lys-48'-linked ubiquitin. May indirectly act as a transcriptional repressor by inhibiting the interaction of NR6A1 with the corepressor NCOR1 ().
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Research Articles on Uimc1

1. Data indicate that RAP80-deficiency promotes genomic instability and causes an increase in cancer risk consistent with the concept that RAP80 exhibits a tumor suppressor function.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with Uimc1 recombinant protein

 Reference Product  PubMed Publications
 Rnf8 recombinant protein  >1 publications with Uimc1 and Rnf8
 Fam175a recombinant protein  >1 publications with Uimc1 and Fam175a

Pathways associated with Uimc1 recombinant protein

 Products by Pathway  Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle Checkpoints Pathway antibodies  Cell Cycle Checkpoints Pathway Diagram
 G2/M Checkpoints Pathway antibodies  G2/M Checkpoints Pathway Diagram
 G2/M DNA Damage Checkpoint Pathway antibodies  G2/M DNA Damage Checkpoint Pathway Diagram

Diseases associated with Uimc1 recombinant protein

 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >1 publications with Uimc1 and Cardiovascular Diseases

Organs/Tissues associated with Uimc1 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Testis Antibodies  >1 publications with Uimc1 and Testis
 Blood Antibodies  >1 publications with Uimc1 and Blood
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