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CROT Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Special Promotion Catalog #: MBS129667
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This gene encodes a member of the carnitine/choline acetyltransferase family. The encoded protein converts 4,8-dimethylnonanoyl-CoA to its corresponding carnitine ester. This transesterification occurs in the peroxisome and is necessary for transport of… More details

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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
CROT, Polyclonal Antibody
Full Product Name
CROT Polyclonal Antibody
Product Gene Name
anti-CROT antibody
Product Synonym Names
COT
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Purity/Purification
Affinity Purification
Concentration
1mg/ml (lot specific)
Preparation and Storage
Store at -20 degree C (regular) or -80 degree C (long term). Avoid freeze / thaw cycles.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Molecular Weight
612
OMIM
606090
3D Structure
ModBase 3D Structure for Q9UKG9
Species
Human
Immunogen
Recombinant protein of human CROT
Calculated Molecular Weight
66kDa

Product Categories/Family for anti-CROT antibody

Polyclonal
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-CROT antibody
Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-CROT antibody
WB: 1:500-1:2000
IHC: 1:50-1:200

Western Blot (WB) of anti-CROT antibody

Western blot analysis of extracts of rat liver, using CROT antibody at 1:3000 dilution.
Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (MBS128200) at 1:10000 dilution.
Lysates/proteins: 25ug per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Detection: ECL Basic Kit.
Exposure time: 5s.
Rabbit Anti-CROT Polyclonal Antibody – Cat# MBS129667

Other Notes

Small volumes of anti-CROT antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CROT purchase

MBS129667 is an antibody targeting CROT. Also known as CROT Polyclonal Antibody. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for CROT. It may not necessarily be applicable to this product.

NCBI GI #
48429265
NCBI GeneID
54677
NCBI Accession #
Q9UKG9.2
UniProt Primary Accession #
Q9UKG9
UniProt Secondary Accession #
Q86V17; Q8IUW9; Q9Y6I2; A4D1D6; E7EQF2
UniProt Related Accession #
Q9UKG9
NCBI Official Full Name
Peroxisomal carnitine O-octanoyltransferase
NCBI Official Synonym Full Names
carnitine O-octanoyltransferase
NCBI Official Symbol
CROT
NCBI Official Synonym Symbols
COT
UniProt Protein Name
Peroxisomal carnitine O-octanoyltransferase
Protein Family
Peroxisomal carnitine O-octanoyltransferase
UniProt Gene Name
CROT
UniProt Synonym Gene Names
COT; COT
UniProt Entry Name
OCTC_HUMAN
NCBI Protein Information
peroxisomal carnitine O-octanoyltransferase; peroxisomal carnitine acyltransferase

UniProt Comments for CROT

CROT: Beta-oxidation of fatty acids. The highest activity concerns the C6 to C10 chain length substrate. Converts the end product of pristanic acid beta oxidation, 4,8-dimethylnonanoyl- CoA, to its corresponding carnitine ester. Belongs to the carnitine/choline acetyltransferase family.

Protein type: EC 2.3.1.137; Transferase

Chromosomal Location of Human Ortholog: 7q21.1

Cellular Component: peroxisomal matrix; intracellular membrane-bound organelle; mitochondrion; peroxisome

Molecular Function: carnitine O-octanoyltransferase activity; receptor binding

Biological Process: coenzyme A metabolic process; fatty acid beta-oxidation using acyl-CoA oxidase; generation of precursor metabolites and energy; fatty acid beta-oxidation; carnitine metabolic process; cellular lipid metabolic process; fatty acid metabolic process; medium-chain fatty acid metabolic process; fatty acid transport
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Research Articles on CROT

1. These results suggest that CROT activity, by controlling the peroxisomal amount of medium chain acyls, may control the peroxisomal oxidative pathway.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-CROT antibody

 Products by Pathway  Pathway Diagram
 Beta-oxidation Of Pristanoyl-CoA Pathway antibodies  Beta-oxidation Of Pristanoyl-CoA Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Lipids And Lipoproteins Pathway antibodies  Metabolism Of Lipids And Lipoproteins Pathway Diagram
 Peroxisomal Lipid Metabolism Pathway antibodies  Peroxisomal Lipid Metabolism Pathway Diagram
 Peroxisome Pathway antibodies  Peroxisome Pathway Diagram
 Peroxisome Pathway antibodies  Peroxisome Pathway Diagram

Diseases associated with anti-CROT antibody

 Disease Name  Pubmed Publications
 Fatty Liver Antibodies  >6 publications with CROT and Fatty Liver
 Atherosclerosis Antibodies  >5 publications with CROT and Atherosclerosis
 Cardiovascular Diseases Antibodies  >4 publications with CROT and Cardiovascular Diseases
 Nervous System Diseases Antibodies  >3 publications with CROT and Nervous System Diseases
 Cell Transformation, Neoplastic Antibodies  >2 publications with CROT and Cell Transformation, Neoplastic
 Liver Diseases Antibodies  >2 publications with CROT and Liver Diseases
 Inflammation Antibodies  >2 publications with CROT and Inflammation
 Neoplasms, Experimental Antibodies  >2 publications with CROT and Neoplasms, Experimental
 Carcinoma, Hepatocellular Antibodies  >1 publications with CROT and Carcinoma, Hepatocellular
 Atrophy Antibodies  >1 publications with CROT and Atrophy

Organs/Tissues associated with anti-CROT antibody

 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >8 publications with CROT and Liver
 Bone Antibodies  >5 publications with CROT and Bone
 Blood Antibodies  >3 publications with CROT and Blood
 Mouth Antibodies  >3 publications with CROT and Mouth
 Skin Antibodies  >2 publications with CROT and Skin
 Muscle Antibodies  >2 publications with CROT and Muscle
 Bone Marrow Antibodies  >2 publications with CROT and Bone Marrow
 Kidney Antibodies  >2 publications with CROT and Kidney
 Brain Antibodies  >1 publications with CROT and Brain
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