VAMP3 Antibody – Rabbit Polyclonal

Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. This gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. Because of its high homology to other known VAMPs, its broad tissue distribution, and its subcellular localization, the protein encoded by this gene was shown to be the human equivalent of the rodent cellubrevin. In platelets the protein resides on a compartment that is not mobilized to the plasma membrane on calcium or thrombin stimulation. [provided by RefSeq, Jul 2008]

VAMP3: SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network. Belongs to the synaptobrevin family.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 1p36.23

Cellular Component: neuron projection; cell surface; intracellular membrane-bound organelle; clathrin-coated vesicle; integral to membrane; clathrin coated vesicle membrane; cytosol; secretory granule; SNARE complex; synaptic vesicle; recycling endosome; apical plasma membrane; plasma membrane; intracellular; cell junction

Molecular Function: SNAP receptor activity; SNARE binding; protein binding; syntaxin-1 binding

Biological Process: vesicle fusion; vesicle-mediated transport; exocytosis; neurotransmitter secretion; Golgi to plasma membrane protein transport; protein complex assembly; positive regulation of immunoglobulin secretion; positive regulation of receptor recycling; retrograde transport, endosome to Golgi; vesicle docking during exocytosis; calcium ion-dependent exocytosis