HIP1 Antibody – Rabbit Polyclonal

HIP1: Plays a role in clathrin-mediated endocytosis and trafficking. Involved in regulating AMPA receptor trafficking in the central nervous system in an NMDA-dependent manner. Enhances androgen receptor (AR)-mediated transcription. May act as a proapoptotic protein that induces cell death by acting through the intrinsic apoptosis pathway. Binds 3-phosphoinositides (via ENTH domain). May act through the ENTH domain to promote cell survival by stabilizing receptor tyrosine kinases following ligand-induced endocytosis. May play a functional role in the cell filament networks. May be required for differentiation, proliferation, and/or survival of somatic and germline progenitors. A chromosomal aberration involving HIP1 is found in a form of chronic myelomonocytic leukemia (CMML). Translocation t(5;7)(q33;q11.2) with PDGFRB. The chimeric HIP1-PDGFRB transcript results from an in-frame fusion of the two genes. The reciprocal PDGFRB-HIP1 transcript is not expressed. Belongs to the SLA2 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Apoptosis; Cytoskeletal

Chromosomal Location of Human Ortholog: 7q11.23

Cellular Component: Golgi apparatus; cytoskeleton; intracellular membrane-bound organelle; membrane; clathrin-coated vesicle; cytoplasm; clathrin coated vesicle membrane; nucleus

Molecular Function: protein binding, bridging; protein binding; clathrin binding; structural constituent of cytoskeleton; actin binding; phosphoinositide binding

Biological Process: caspase activation; regulation of apoptosis; clathrin cage assembly; regulation of transcription, DNA-dependent; transcription, DNA-dependent; apoptosis; endocytosis; actin cytoskeleton organization and biogenesis; cell differentiation; positive regulation of receptor-mediated endocytosis

Disease: Prostate Cancer