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Histone Deacetylase 1 (HDAC1) Bovine Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1297273

Histone acetylation and deacetylation, catalyzed by multisubunit complexes, play a key role in the regulation of eukaryotic gene expression. This protein belongs to the histone deacetylaseacucapha family and is a component of the histone deacetylase complex.… More details

$1265 / 0.02 mg (E-Coli) +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Histone deacetylase 1 (HDAC1), Recombinant Protein
Full Product Name
Recombinant Bovine Histone deacetylase 1 (HDAC1)
Product Gene Name
HDAC1 recombinant protein
Product Synonym Gene Name
HDAC1
Sequence
MAQTQGTKRK VCYYYDGDVG NYYYGQGHPM KPHRIRMTHN LLLNYGLYRK MEIYRPHKAN AEEMTKYHSD DYIKFLRSIR PDNMSEYSKQ MQRFNVGEDC PVFDGLFEFC QLSTGGSVAS AVKLNKQQTD IAVNWAGGLH HAKKSEASGF CYVNDIVLAI LELLKYHQRV LYIDIDIHHG DGVEEAFYTT DRVMTVSFHK YGEYFPGTGD LRDIGAGKGK YYAVNYPLRD GIDDESYEAI FKPVMSKVME MFQPSAVVLQ CGSDSLSGDR LGCFNLTIKG HAKCVEFVKS FNLPMLMLGG GGYTIRNVAR CWTYETAVAL DTEIPNELPY NDYFEYFGPD FKLHISPSNM TNQNTNEYLE KIKQRLFENL RMLPHAPGVQ MQAIPEDAIP EESGDEDEED PDKRISICSS DKRIACEEEF SDSDEEGEGG RKNSSNFKKA KRVKTEDEKE KDPEEKKEVT EEEKTKEEKQ EAKGVKEEVK LA
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Molecular Weight
55,106 Da
Sequence Positions
1-482, full length protein
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
3D Structure
ModBase 3D Structure for Q32PJ8
Species
Bovine
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of HDAC1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for HDAC1 purchase

MBS1297273 is a recombinant protein targeting HDAC1. Also known as Recombinant Bovine Histone deacetylase 1 (HDAC1). Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for HDAC1. It may not necessarily be applicable to this product.

NCBI GI #
82697313
NCBI GeneID
404126
NCBI Accession #
NP_001032521.1
UniProt Primary Accession #
Q32PJ8
UniProt Related Accession #
Q32PJ8
GenBank Nucleotide #
NM_001037444.2
NCBI Official Full Name
histone deacetylase 1
NCBI Official Synonym Full Names
histone deacetylase 1
NCBI Official Symbol
HDAC1
UniProt Protein Name
Histone deacetylase 1
UniProt Gene Name
HDAC1
UniProt Synonym Gene Names
HD1
NCBI Protein Information
histone deacetylase 1

UniProt Comments for HDAC1

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates SP proteins, SP1 and SP3, and regulates their function. Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST-mediated transcription in resting neurons. Upon calcium stimulation, HDAC1 is released from the complex and CREBBP is recruited, which facilitates transcriptional activation. Deacetylates TSHZ3 and regulates its transcriptional repressor activity. Deacetylates 'Lys-310' in RELA and thereby inhibits the transcriptional activity of NF-kappa-B. Deacetylates NR1D2 and abrogates the effect of KAT5-mediated relieving of NR1D2 transcription repression activity. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. Involved in CIART-mediated transcriptional repression of the circadian transcriptional activator: CLOCK-ARNTL/BMAL1 heterodimer. Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex or CRY1 through histone deacetylation.
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Research Articles on HDAC1

1. The effect of p53 expression on the development of cloned embryos, and its interaction with HDAC1 and DNMT3A are reported.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with HDAC1 recombinant protein

 Reference Product  PubMed Publications
 SIN3A recombinant protein  >82 publications with HDAC1 and SIN3A
 RBL2 recombinant protein  >12 publications with HDAC1 and RBL2
 CTBP1 recombinant protein  >8 publications with HDAC1 and CTBP1
 SMAD4 recombinant protein  >8 publications with HDAC1 and SMAD4
 RB1 recombinant protein  >6 publications with HDAC1 and RB1
 KAT2B recombinant protein  >3 publications with HDAC1 and KAT2B
 TGIF1 recombinant protein  >2 publications with HDAC1 and TGIF1
 RBPJ recombinant protein  >2 publications with HDAC1 and RBPJ

Pathways associated with HDAC1 recombinant protein

 Products by Pathway  Pathway Diagram
 AMER1 Mutants Destabilize The Destruction Complex Pathway antibodies  AMER1 Mutants Destabilize The Destruction Complex Pathway Diagram
 APC Truncation Mutants Are Not K63 Polyubiquitinated Pathway antibodies  APC Truncation Mutants Are Not K63 Polyubiquitinated Pathway Diagram
 APC Truncation Mutants Have Impaired AXIN Binding Pathway antibodies  APC Truncation Mutants Have Impaired AXIN Binding Pathway Diagram
 AXIN Missense Mutants Destabilize The Destruction Complex Pathway antibodies  AXIN Missense Mutants Destabilize The Destruction Complex Pathway Diagram
 AXIN Mutants Destabilize The Destruction Complex, Activating WNT Signaling Pathway antibodies  AXIN Mutants Destabilize The Destruction Complex, Activating WNT Signaling Pathway Diagram
 Alcoholism Pathway antibodies  Alcoholism Pathway Diagram
 Alcoholism Pathway antibodies  Alcoholism Pathway Diagram
 Androgen Receptor Signaling Pathway antibodies  Androgen Receptor Signaling Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle, Mitotic Pathway antibodies  Cell Cycle, Mitotic Pathway Diagram

Diseases associated with HDAC1 recombinant protein

 Disease Name  Pubmed Publications
 Adenocarcinoma Antibodies  >92 publications with HDAC1 and Adenocarcinoma
 Breast Neoplasms Antibodies  >86 publications with HDAC1 and Breast Neoplasms
 Inflammation Antibodies  >58 publications with HDAC1 and Inflammation
 Necrosis Antibodies  >55 publications with HDAC1 and Necrosis
 Nervous System Diseases Antibodies  >55 publications with HDAC1 and Nervous System Diseases
 Liver Diseases Antibodies  >52 publications with HDAC1 and Liver Diseases
 Disease Models, Animal Antibodies  >44 publications with HDAC1 and Disease Models, Animal
 Liver Neoplasms Antibodies  >41 publications with HDAC1 and Liver Neoplasms
 Neoplasm Metastasis Antibodies  >40 publications with HDAC1 and Neoplasm Metastasis
 Cell Transformation, Neoplastic Antibodies  >39 publications with HDAC1 and Cell Transformation, Neoplastic

Organs/Tissues associated with HDAC1 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >79 publications with HDAC1 and Liver
 Brain Antibodies  >70 publications with HDAC1 and Brain
 Lung Antibodies  >60 publications with HDAC1 and Lung
 Muscle Antibodies  >47 publications with HDAC1 and Muscle
 Kidney Antibodies  >36 publications with HDAC1 and Kidney
 Skin Antibodies  >22 publications with HDAC1 and Skin
 Testis Antibodies  >10 publications with HDAC1 and Testis
 Ovary Antibodies  >8 publications with HDAC1 and Ovary
 Cartilage Antibodies  >8 publications with HDAC1 and Cartilage
 Intestine Antibodies  >8 publications with HDAC1 and Intestine
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