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SF3B2 Antibody – Rabbit

For Research Use Only. Not for use in diagnostic procedures. Special Promotion Catalog #: MBS129733
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This gene encodes subunit 2 of the splicing factor 3b protein complex. Splicing factor 3b,together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclearribonucleoproteins complex (U2 snRNP). The splicing factor 3b/3a complex binds pre-mRNA… More details

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Testing Data View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
SF3B2, Antibody
Full Product Name
SF3B2 Polyclonal Antibody
Product Gene Name
anti-SF3B2 antibody
Product Synonym Names
Cus1; SF3b1; SAP145; SF3B145; SF3b150
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
PBS with 0.02% sodium azide,50% glycerol,pH7.3
Purity/Purification
Affinity purification
Preparation and Storage
Store at -20°C. Avoid freeze / thaw cycles.
Molecular Weight
Observed MW: 140kDa
Calculated MW: 100kDa
OMIM
phenotype 608761
3D Structure
ModBase 3D Structure for Q13435
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids616-895 of human SF3B2 (NP_006833.2).

Product Categories/Family for anti-SF3B2 antibody

Polyclonal
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-SF3B2 antibody
Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
Application Notes for anti-SF3B2 antibody
WB 1:500 - 1:2000
IHC 1:50 - 1:200
IF 1:50 - 1:200

Western Blot (WB) of anti-SF3B2 antibody

Western blot analysis of extracts of various cell lines, using SF3B2 antibody (MBS129733) at 1:1000 dilution.
Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (MBS128200) at 1:10000 dilution.
Lysates/proteins: 25ug per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Detection: ECL Basic Kit.
Exposure time: 5s.
Rabbit Anti-SF3B2 Antibody – Cat# MBS129733

Immunohistochemistry (IHC) of anti-SF3B2 antibody

Immunohistochemistry of paraffin-embedded rat heart using SF3B2 antibody(MBS129733) at dilution of 1:100 (40x lens).
Rabbit Anti-SF3B2 Antibody, Immunohistochemistry (IHC) – Cat# MBS129733

Immunohistochemistry (IHC) of anti-SF3B2 antibody

Immunohistochemistry of paraffin-embedded human lung cancer using SF3B2 antibody (MBS129733) at dilution of1:100 (40x lens).
Rabbit Anti-SF3B2 Antibody, Immunohistochemistry (IHC) – Cat# MBS129733

Immunohistochemistry (IHC) of anti-SF3B2 antibody

Immunohistochemistry of paraffin-embedded mouse Intestine using SF3B2 antibody (MBS129733) at dilution of 1:100 (40xlens).
Rabbit Anti-SF3B2 Antibody, Immunohistochemistry (IHC) – Cat# MBS129733

Immunofluorescence (IF) of anti-SF3B2 antibody

Immunofluorescence analysis of A-549cells using SF3B2 antibody (MBS129733)
Rabbit Anti-SF3B2 Antibody, Immunofluorescence (IF) – Cat# MBS129733

Other Notes

Small volumes of anti-SF3B2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SF3B2 purchase

MBS129733 is an antibody targeting SF3B2. Also known as SF3B2 Polyclonal Antibody. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for SF3B2. It may not necessarily be applicable to this product.

NCBI GI #
56404957
NCBI GeneID
10992
NCBI Accession #
Q9GZV3.1
UniProt Primary Accession #
Q13435
UniProt Secondary Accession #
Q53TF2
UniProt Related Accession #
Q9GZV3
NCBI Official Full Name
High affinity choline transporter 1
NCBI Official Synonym Full Names
solute carrier family 5 (sodium/choline cotransporter), member 7
NCBI Official Symbol
SLC5A7
NCBI Official Synonym Symbols
CHT; CHT1; hCHT; HMN7A
UniProt Protein Name
High affinity choline transporter 1
UniProt Synonym Protein Names
Hemicholinium-3-sensitive choline transporter; CHT; Solute carrier family 5 member 7
Protein Family
Splicing factor
UniProt Gene Name
SLC5A7
UniProt Synonym Gene Names
CHT1; CHT
UniProt Entry Name
SC5A7_HUMAN
NCBI Protein Information
high affinity choline transporter 1; solute carrier family 5 member 7; hemicholinium-3-sensitive choline transporter; solute carrier family 5 (choline transporter), member 7; high affinity choline transporter; hemicholinium-3-sensitive choline transporter

NCBI Summary for SF3B2

Choline is a direct precursor of acetylcholine (ACh), a neurotransmitter of the central and peripheral nervous system that regulates a variety of autonomic, cognitive, and motor functions. SLC5A7 is a Na(+)- and Cl(-)- dependent high-affinity transporter that mediates the uptake of choline for acetylcholine synthesis in cholinergic neurons (Apparsundaram et al., 2000 [PubMed 11027560]).[supplied by OMIM, Mar 2008]
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UniProt Comments for SF3B2

SLC5A7: Imports choline from the extracellular space to the neuron with high affinity. Choline uptake is the rate-limiting step in acetylcholine synthesis. Sodium ion- and chloride ion- dependent. Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.

Protein type: Membrane protein, multi-pass; Membrane protein, integral; Transporter; Transporter, SLC family

Chromosomal Location of Human Ortholog: 2q12

Cellular Component: cell soma; integral to membrane; plasma membrane

Molecular Function: choline binding; choline transmembrane transporter activity; choline:sodium symporter activity

Biological Process: synaptic transmission; acetylcholine biosynthetic process; neurotransmitter secretion; sodium ion transport; neuromuscular synaptic transmission; choline transport; transmembrane transport; synaptic transmission, cholinergic

Disease: Neuronopathy, Distal Hereditary Motor, Type Viia
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Research Articles on SF3B2

1. [review] The critical role of CHT in maintaining cholinergic transmission indicates that it could be a target for therapeutic intervention to promote acetylcholine synthesis, the accomplishment of which has not been adequately addressed.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-SF3B2 antibody

 Reference Product  PubMed Publications
 CHAT antibody  >8 publications with SF3B2 and CHAT
 SLC18A3 antibody  >5 publications with SF3B2 and SLC18A3
 NEDD4 antibody  >1 publications with SF3B2 and NEDD4

Pathways associated with anti-SF3B2 antibody

 Products by Pathway  Pathway Diagram
 Acetylcholine Neurotransmitter Release Cycle Pathway antibodies  Acetylcholine Neurotransmitter Release Cycle Pathway Diagram
 Choline Metabolism In Cancer Pathway antibodies  Choline Metabolism In Cancer Pathway Diagram
 Choline Metabolism In Cancer Pathway antibodies  Choline Metabolism In Cancer Pathway Diagram
 Cholinergic Synapse Pathway antibodies  Cholinergic Synapse Pathway Diagram
 Monoamine Transport Pathway antibodies  Monoamine Transport Pathway Diagram
 Neuronal System Pathway antibodies  Neuronal System Pathway Diagram
 Neurotransmitter Release Cycle Pathway antibodies  Neurotransmitter Release Cycle Pathway Diagram
 SLC-mediated Transmembrane Transport Pathway antibodies  SLC-mediated Transmembrane Transport Pathway Diagram
 Transmembrane Transport Of Small Molecules Pathway antibodies  Transmembrane Transport Of Small Molecules Pathway Diagram
 Transmission Across Chemical Synapses Pathway antibodies  Transmission Across Chemical Synapses Pathway Diagram

Diseases associated with anti-SF3B2 antibody

 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >5 publications with SF3B2 and Nervous System Diseases
 Movement Disorders Antibodies  >2 publications with SF3B2 and Movement Disorders
 Learning Disorders Antibodies  >2 publications with SF3B2 and Learning Disorders
 Memory Disorders Antibodies  >2 publications with SF3B2 and Memory Disorders
 Inflammation Antibodies  >2 publications with SF3B2 and Inflammation
 Neurobehavioral Manifestations Antibodies  >1 publications with SF3B2 and Neurobehavioral Manifestations
 Neurodegenerative Diseases Antibodies  >1 publications with SF3B2 and Neurodegenerative Diseases
 Colonic Neoplasms Antibodies  >1 publications with SF3B2 and Colonic Neoplasms
 Lung Diseases Antibodies  >1 publications with SF3B2 and Lung Diseases
 Brain Diseases Antibodies  >1 publications with SF3B2 and Brain Diseases

Organs/Tissues associated with anti-SF3B2 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >11 publications with SF3B2 and Brain
 Nerve Antibodies  >6 publications with SF3B2 and Nerve
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