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AGTR2 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Special Promotion Catalog #: MBS129780
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The protein encoded by this gene belongs to the G-protein coupled receptor 1 family, and functions as a receptor for angiotensin II. It is an intergral membrane protein that is highly expressed in fetus, but scantily in adult tissues, except brain, adrenal… More details

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Product Overview

Product Name
AGTR2, Polyclonal Antibody
Full Product Name
AGTR2 Polyclonal Antibody
Product Gene Name
anti-AGTR2 antibody
Product Synonym Names
AT2; ATGR2; MRX88
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Purity/Purification
Affinity Purification
Concentration
1mg/ml (lot specific)
Preparation and Storage
Store at -20 degree C (regular) or -80 degree C (long term). Avoid freeze / thaw cycles.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Molecular Weight
363
OMIM
300034
3D Structure
ModBase 3D Structure for P50052
Species
Human
Route
Synthetic Peptide
Immunogen
A synthetic peptide of human AGTR2
Calculated Molecular Weight
41kDa

Product Categories/Family for anti-AGTR2 antibody

Polyclonal
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-AGTR2 antibody
Immunohistochemistry (IHC)
Application Notes for anti-AGTR2 antibody
IHC: 1:20 - 1:100

Other Notes

Small volumes of anti-AGTR2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for AGTR2 purchase

MBS129780 is an antibody targeting AGTR2. Also known as AGTR2 Polyclonal Antibody. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for AGTR2. It may not necessarily be applicable to this product.

NCBI GI #
1703214
NCBI GeneID
186
NCBI Accession #
P50052.1
UniProt Primary Accession #
P50052
UniProt Secondary Accession #
Q13016; Q6FGY7; B2R9V1
UniProt Related Accession #
P50052; AAB34100
NCBI Official Full Name
Type-2 angiotensin II receptor
NCBI Official Synonym Full Names
angiotensin II receptor, type 2
NCBI Official Symbol
AGTR2
NCBI Official Synonym Symbols
AT2; ATGR2; MRX88
UniProt Protein Name
Type-2 angiotensin II receptor
UniProt Synonym Protein Names
Angiotensin II type-2 receptor; AT2
Protein Family
Type-2 angiotensin II receptor
UniProt Gene Name
AGTR2
UniProt Synonym Gene Names
AT2
UniProt Entry Name
AGTR2_HUMAN
NCBI Protein Information
type-2 angiotensin II receptor; angiotensin II type-2 receptor

UniProt Comments for AGTR2

AT2: Receptor for angiotensin II. Cooperates with MTUS1 to inhibit ERK2 activation and cell proliferation. Defects in AGTR2 are the cause of mental retardation X- linked type 88 (MRX88). Mental retardation is characterized by significantly below average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. Belongs to the G-protein coupled receptor 1 family.

Protein type: Membrane protein, multi-pass; GPCR, family 1; Membrane protein, integral; Receptor, GPCR

Chromosomal Location of Human Ortholog: Xq22-q23

Cellular Component: integral to plasma membrane; perinuclear region of cytoplasm; extracellular region; plasma membrane

Molecular Function: protein binding; receptor antagonist activity; angiotensin type II receptor activity; peptide hormone binding; transcription factor binding

Biological Process: positive regulation of phosphoprotein phosphatase activity; negative regulation of icosanoid secretion; regulation of transcription factor import into nucleus; positive regulation of nitric oxide biosynthetic process; negative regulation of heart rate; negative regulation of nerve growth factor receptor signaling pathway; positive regulation of transcription, DNA-dependent; renin-angiotensin regulation of aldosterone production; dopamine biosynthetic process; positive regulation of vasodilation; angiotensin mediated vasodilation involved in regulation of systemic arterial blood pressure; cerebellar cortex development; cell surface receptor linked signal transduction; regulation of systemic arterial blood pressure by circulatory renin-angiotensin; regulation of blood pressure; positive regulation of cell proliferation; inflammatory response; cellular sodium ion homeostasis; positive regulation of nitric-oxide synthase activity; negative regulation of blood vessel endothelial cell migration; response to organic nitrogen; brain renin-angiotensin system; G-protein coupled receptor protein signaling pathway; negative regulation of fibroblast proliferation; G-protein signaling, coupled to cGMP nucleotide second messenger; blood vessel remodeling; brain development; negative regulation of cell growth; nitric oxide mediated signal transduction; positive regulation of cytokine secretion
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Research Articles on AGTR2

1. We concluded that ATR1 CC genotype and ATR2 G allele increased the susceptibility of Egyptian males to have coronary artery disease .

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-AGTR2 antibody

 Reference Product  PubMed Publications
 AGTR1 antibody  >62 publications with AGTR2 and AGTR1
 BDKRB2 antibody  >60 publications with AGTR2 and BDKRB2
 POMC antibody  >10 publications with AGTR2 and POMC
 ADORA1 antibody  >1 publications with AGTR2 and ADORA1
 ADCY2 antibody  >1 publications with AGTR2 and ADCY2
 KNG1 antibody  >1 publications with AGTR2 and KNG1

Pathways associated with anti-AGTR2 antibody

 Products by Pathway  Pathway Diagram
 ACE Inhibitor Pathway antibodies  ACE Inhibitor Pathway Diagram
 Adrenergic Signaling In Cardiomyocytes Pathway antibodies  Adrenergic Signaling In Cardiomyocytes Pathway Diagram
 Adrenergic Signaling In Cardiomyocytes Pathway antibodies  Adrenergic Signaling In Cardiomyocytes Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway antibodies  Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 G Alpha (i) Signalling Events Pathway antibodies  G Alpha (i) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 GPCRs, Class A Rhodopsin-like Pathway antibodies  GPCRs, Class A Rhodopsin-like Pathway Diagram

Diseases associated with anti-AGTR2 antibody

 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >1030 publications with AGTR2 and Cardiovascular Diseases
 Hypertension Antibodies  >867 publications with AGTR2 and Hypertension
 Heart Diseases Antibodies  >466 publications with AGTR2 and Heart Diseases
 Hypertrophy Antibodies  >287 publications with AGTR2 and Hypertrophy
 Kidney Diseases Antibodies  >267 publications with AGTR2 and Kidney Diseases
 Disease Models, Animal Antibodies  >216 publications with AGTR2 and Disease Models, Animal
 Heart Failure Antibodies  >179 publications with AGTR2 and Heart Failure
 Fibrosis Antibodies  >164 publications with AGTR2 and Fibrosis
 Myocardial Infarction Antibodies  >157 publications with AGTR2 and Myocardial Infarction
 Cardiomegaly Antibodies  >156 publications with AGTR2 and Cardiomegaly

Organs/Tissues associated with anti-AGTR2 antibody

 Organ/Tissue Name  Pubmed Publications
 Heart Antibodies  >745 publications with AGTR2 and Heart
 Kidney Antibodies  >654 publications with AGTR2 and Kidney
 Brain Antibodies  >337 publications with AGTR2 and Brain
 Lung Antibodies  >69 publications with AGTR2 and Lung
 Uterus Antibodies  >44 publications with AGTR2 and Uterus
 Testis Antibodies  >7 publications with AGTR2 and Testis
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