Rabbit Anti-HSD11B1 Polyclonal Antibody – Cat# MBS129838

Western blot analysis of extracts of mouse liver, using HSD11B1 antibody at 1:1000 dilution.
Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (MBS128200) at 1:10000 dilution.
Lysates/proteins: 25ug per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Detection: ECL Enhanced Kit.
Exposure time: 90s.

HSD11B1 Antibody – Rabbit Polyclonal

Name: HSD11B1 Antibody; Polyclonal; Rabbit; Human/Mouse-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS129838
Price: 225 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS129838

The protein encoded by this gene is a microsomal enzyme that catalyzes the conversion of the stress hormone cortisol to the inactive metabolite cortisone. In addition, the encoded protein can catalyze the reverse reaction, the conversion of cortisone to… More details

$225 / 0.02 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

HSD11B1, Polyclonal Antibody

Full Product Name

HSD11B1 Polyclonal Antibody

Product Gene Name

anti-HSD11B1 antibody

Product Synonym Names

11-beta-HSD1;11-DH;CORTRD2;HDL;HSD11;HSD11B;HS D11L;SDR26C1

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human, Mouse

Purity/Purification

Affinity Purification

Concentration

1mg/ml (lot specific)

Preparation and Storage

Store at -20 degree C. Avoid freeze / thaw cycles.

OMIM

gene 604931

3D Structure

ModBase 3D Structure for P28845

Immunogen

Recombinant protein of human HSD11B1

Calculated Molecular Weight

32kDa

Observed Molecular Weight

32kDa

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Product Categories/Family for anti-HSD11B1 antibody

Polyclonal

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Applications Tested/Suitable for anti-HSD11B1 antibody

Western Blot (WB)

Application Notes for anti-HSD11B1 antibody

WB: 1:500 - 1:2000

Other Notes

Small volumes of anti-HSD11B1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for HSD11B1 purchase

MBS129838 is an antibody targeting HSD11B1. Also known as HSD11B1 Polyclonal Antibody. Reactive in Human, Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for HSD11B1. It may not necessarily be applicable to this product.

NCBI GI #

118569

NCBI GeneID

3290

NCBI Accession #

P28845.3

UniProt Primary Accession #

P28845

UniProt Secondary Accession #

B2R9Z1; D3DT89

UniProt Related Accession #

P28845

NCBI Official Full Name

Corticosteroid 11-beta-dehydrogenase isozyme 1

NCBI Official Synonym Full Names

hydroxysteroid (11-beta) dehydrogenase 1

NCBI Official Symbol

HSD11B1

NCBI Official Synonym Symbols

HDL; 11-DH; HSD11; HSD11B; HSD11L; CORTRD2; SDR26C1; 11-beta-HSD1

UniProt Protein Name

Corticosteroid 11-beta-dehydrogenase isozyme 1

UniProt Synonym Protein Names

11-beta-hydroxysteroid dehydrogenase 1; 11-DH; 11-beta-HSD1

Protein Family

Corticosteroid 11-beta-dehydrogenase isozyme

UniProt Gene Name

HSD11B1

UniProt Synonym Gene Names

HSD11; HSD11L; 11-DH; 11-beta-HSD1

UniProt Entry Name

DHI1_HUMAN

NCBI Protein Information

corticosteroid 11-beta-dehydrogenase isozyme 1; short chain dehydrogenase/reductase family 26C, member 1

UniProt Comments for HSD11B1

HSD11B1: Catalyzes reversibly the conversion of cortisol to the inactive metabolite cortisone. Catalyzes reversibly the conversion of 7-ketocholesterol to 7-beta-hydroxycholesterol. In intact cells, the reaction runs only in one direction, from 7- ketocholesterol to 7-beta-hydroxycholesterol. Defects in HSD11B1 are a cause of cortisone reductase deficiency (CRD). In CRD, activation of cortisone to cortisol does not occur, resulting in adrenocorticotropin-mediated androgen excess and a phenotype resembling polycystic ovary syndrome (PCOS). Belongs to the short-chain dehydrogenases/reductases (SDR) family.

Protein type: Lipid Metabolism - androgen and estrogen; Lipid Metabolism - C21-steroid hormone; Endoplasmic reticulum; EC 1.1.1.146; Membrane protein, integral; Oxidoreductase

Chromosomal Location of Human Ortholog: 1q32-q41

Cellular Component: endoplasmic reticulum membrane; membrane; integral to membrane

Molecular Function: 11-beta-hydroxysteroid dehydrogenase activity

Biological Process: steroid metabolic process; glucocorticoid biosynthetic process; lung development

Disease: Cortisone Reductase Deficiency 2

Research Articles on HSD11B1

1. Development of specific inhibitors targeting 11beta-HSD1 might be a promising way to improve impaired insulin-stimulated glucose uptake.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-HSD11B1 antibody

Reference Product	PubMed Publications
CYP11B1 antibody	>4 publications with HSD11B1 and CYP11B1
AKR1C4 antibody	>4 publications with HSD11B1 and AKR1C4
HSD3B1 antibody	>4 publications with HSD11B1 and HSD3B1
CYP11B2 antibody	>4 publications with HSD11B1 and CYP11B2
HSD3B2 antibody	>3 publications with HSD11B1 and HSD3B2
AKR1D1 antibody	>1 publications with HSD11B1 and AKR1D1

Pathways associated with anti-HSD11B1 antibody

Products by Pathway	Pathway Diagram
C21-Steroid Hormone Biosynthesis, Progesterone => Cortisol/cortisone Pathway antibodies	C21-Steroid Hormone Biosynthesis, Progesterone => Cortisol/cortisone Pathway Diagram
C21-Steroid Hormone Biosynthesis, Progesterone => Cortisol/cortisone Pathway antibodies	C21-Steroid Hormone Biosynthesis, Progesterone => Cortisol/cortisone Pathway Diagram
Chemical Carcinogenesis Pathway antibodies	Chemical Carcinogenesis Pathway Diagram
Chemical Carcinogenesis Pathway antibodies	Chemical Carcinogenesis Pathway Diagram
Glucocorticoid & Mineralcorticoid Metabolism Pathway antibodies	Glucocorticoid & Mineralcorticoid Metabolism Pathway Diagram
Glucocorticoid Biosynthesis Pathway antibodies	Glucocorticoid Biosynthesis Pathway Diagram
Metabolic Pathways antibodies	Metabolic Pathways Diagram
Metabolism Pathway antibodies	Metabolism Pathway Diagram
Metabolism Of Lipids And Lipoproteins Pathway antibodies	Metabolism Of Lipids And Lipoproteins Pathway Diagram
Metabolism Of Steroid Hormones And Vitamin D Pathway antibodies	Metabolism Of Steroid Hormones And Vitamin D Pathway Diagram

Diseases associated with anti-HSD11B1 antibody

Disease Name	Pubmed Publications
Obesity Antibodies	>84 publications with HSD11B1 and Obesity
Insulin Resistance Antibodies	>52 publications with HSD11B1 and Insulin Resistance
Hypertension Antibodies	>32 publications with HSD11B1 and Hypertension
Cardiovascular Diseases Antibodies	>22 publications with HSD11B1 and Cardiovascular Diseases
Liver Diseases Antibodies	>18 publications with HSD11B1 and Liver Diseases
Inflammation Antibodies	>18 publications with HSD11B1 and Inflammation
Obesity, Abdominal Antibodies	>17 publications with HSD11B1 and Obesity, Abdominal
Weight Gain Antibodies	>12 publications with HSD11B1 and Weight Gain
Necrosis Antibodies	>11 publications with HSD11B1 and Necrosis
Cortisone reductase deficiency Antibodies	>11 publications with HSD11B1 and Cortisone reductase deficiency

Organs/Tissues associated with anti-HSD11B1 antibody

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>75 publications with HSD11B1 and Blood
Liver Antibodies	>61 publications with HSD11B1 and Liver
Connective Tissue Antibodies	>51 publications with HSD11B1 and Connective Tissue
Ovary Antibodies	>25 publications with HSD11B1 and Ovary
Kidney Antibodies	>21 publications with HSD11B1 and Kidney
Brain Antibodies	>18 publications with HSD11B1 and Brain
Muscle Antibodies	>14 publications with HSD11B1 and Muscle
Lung Antibodies	>13 publications with HSD11B1 and Lung
Placenta Antibodies	>10 publications with HSD11B1 and Placenta
Uterus Antibodies	>8 publications with HSD11B1 and Uterus