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MLPH Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Special Promotion Catalog #: MBS129843
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This gene encodes a member of the exophilin subfamily of Rab effector proteins. The protein forms a ternary complex with the small Ras-related GTPase Rab27A in its GTP-bound form and the motor protein myosin Va. A similar protein complex in mouse functions to… More details

$225 / 0.02 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
MLPH, Polyclonal Antibody
Full Product Name
MLPH Polyclonal Antibody
Product Gene Name
anti-MLPH antibody
Product Synonym Names
SLAC2-A
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Purity/Purification
Affinity Purification
Concentration
1mg/ml (lot specific)
Preparation and Storage
Store at -20 degree C (regular) or -80 degree C (long term). Avoid freeze / thaw cycles.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Molecular Weight
600
OMIM
gene 609227
3D Structure
ModBase 3D Structure for Q9BV36
Species
Human
Immunogen
Recombinant protein of human MLPH
Calculated Molecular Weight
65kDa

Product Categories/Family for anti-MLPH antibody

Polyclonal
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-MLPH antibody
Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-MLPH antibody
WB: 1:500 - 1:2000
IHC: 1:50 - 1:200

Western Blot (WB) of anti-MLPH antibody

Western blot analysis of extracts of various cell lines, using MLPH antibody at 1:1000 dilution.
Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (MBS128200) at 1:10000 dilution.
Lysates/proteins: 25ug per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Detection: ECL Basic Kit.
Exposure time: 90s.
Rabbit Anti-MLPH Polyclonal Antibody – Cat# MBS129843

Other Notes

Small volumes of anti-MLPH antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for MLPH purchase

MBS129843 is an antibody targeting MLPH. Also known as MLPH Polyclonal Antibody. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for MLPH. It may not necessarily be applicable to this product.

NCBI GI #
32129730
NCBI GeneID
79083
NCBI Accession #
Q9BV36.1
UniProt Primary Accession #
Q9BV36
UniProt Secondary Accession #
Q9HA71; B3KSS2; B4DKW7; G5E9G5
UniProt Related Accession #
Q9BV36
NCBI Official Full Name
Melanophilin
NCBI Official Synonym Full Names
melanophilin
NCBI Official Symbol
MLPH
NCBI Official Synonym Symbols
SLAC2-A
UniProt Protein Name
Melanophilin
UniProt Synonym Protein Names
Exophilin-3; Slp homolog lacking C2 domains a; SlaC2-a; Synaptotagmin-like protein 2a
Protein Family
Melanophilin
UniProt Gene Name
MLPH
UniProt Synonym Gene Names
SLAC2A; SlaC2-a
UniProt Entry Name
MELPH_HUMAN
NCBI Protein Information
melanophilin; exophilin-3; synaptotagmin-like protein 2a; slp homolog lacking C2 domains a

UniProt Comments for MLPH

MLPH: Rab effector protein involved in melanosome transport. Serves as link between melanosome-bound RAB27A and the motor protein MYO5A. Defects in MLPH are a cause of Griscelli syndrome type 3 (GS3). GS3 is a rare autosomal recessive disorder characterized by pigmentary dilution of the skin and hair, the presence of large clumps of pigment in hair shafts, and an accumulation of melanosomes in melanocytes, without other clinical manifestations. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: 2q37.3

Cellular Component: cortical actin cytoskeleton; perinuclear region of cytoplasm; dendrite; stress fiber; microtubule organizing center

Molecular Function: microtubule plus-end binding; metal ion binding; myosin V binding; actin binding; Rab GTPase binding

Biological Process: melanocyte differentiation; melanosome localization; protein targeting

Disease: Griscelli Syndrome, Type 3
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Research Articles on MLPH

1. The results showed that Rab27A(Q78L) is unable to localize on mature melanosomes and that its inhibitory activity on melanosome transport is completely dependent on its binding to the Rab27A effector Slac2-a/melanophilin.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-MLPH antibody

 Reference Product  PubMed Publications
 RAB27A antibody  >56 publications with MLPH and RAB27A
 MYO5A antibody  >34 publications with MLPH and MYO5A
 RAB27B antibody  >6 publications with MLPH and RAB27B
 SYTL2 antibody  >3 publications with MLPH and SYTL2

Pathways associated with anti-MLPH antibody

 Products by Pathway  Pathway Diagram
 Deregulation Of Rab And Rab Effector Genes In Bladder Cancer Pathway antibodies  Deregulation Of Rab And Rab Effector Genes In Bladder Cancer Pathway Diagram

Diseases associated with anti-MLPH antibody

 Disease Name  Pubmed Publications
 Griscelli syndrome type 3 Antibodies  >3 publications with MLPH and Griscelli syndrome type 3
 Disease Models, Animal Antibodies  >2 publications with MLPH and Disease Models, Animal
 Inflammation Antibodies  >2 publications with MLPH and Inflammation
 Lung Diseases Antibodies  >2 publications with MLPH and Lung Diseases
 Premature Birth Antibodies  >1 publications with MLPH and Premature Birth
 Urinary Bladder Neoplasms Antibodies  >1 publications with MLPH and Urinary Bladder Neoplasms
 Congenital Abnormalities Antibodies  >1 publications with MLPH and Congenital Abnormalities
 Cell Transformation, Neoplastic Antibodies  >1 publications with MLPH and Cell Transformation, Neoplastic
 Adenocarcinoma Antibodies  >1 publications with MLPH and Adenocarcinoma
 Lung Neoplasms Antibodies  >1 publications with MLPH and Lung Neoplasms

Organs/Tissues associated with anti-MLPH antibody

 Organ/Tissue Name  Pubmed Publications
 Skin Antibodies  >19 publications with MLPH and Skin
 Lung Antibodies  >11 publications with MLPH and Lung
 Heart Antibodies  >8 publications with MLPH and Heart
 Brain Antibodies  >7 publications with MLPH and Brain
 Eye Antibodies  >2 publications with MLPH and Eye
 Nerve Antibodies  >2 publications with MLPH and Nerve
 Bladder Antibodies  >1 publications with MLPH and Bladder
 Vascular Antibodies  >1 publications with MLPH and Vascular
 Mouth Antibodies  >1 publications with MLPH and Mouth
 Kidney Antibodies  >1 publications with MLPH and Kidney
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