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ALDH6A1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Special Promotion Catalog #: MBS129898
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This gene encodes a member of the aldehyde dehydrogenase protein family. The encoded protein is a mitochondrial methylmalonate semialdehyde dehydrogenase that plays a role in the valine and pyrimidine catabolic pathways. This protein catalyzes the… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
ALDH6A1, Polyclonal Antibody
Full Product Name
ALDH6A1 Polyclonal Antibody
Product Gene Name
anti-ALDH6A1 antibody
Product Synonym Names
MMSDH; MMSADHA
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Purity/Purification
Affinity Purification
Concentration
1mg/ml (lot specific)
Preparation and Storage
Store at -20 degree C (regular) or -80 degree C (long term). Avoid freeze / thaw cycles.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Molecular Weight
535
OMIM
gene 614105
3D Structure
ModBase 3D Structure for Q02252
Species
Human
Immunogen
Recombinant protein of human ALDH6A1
Calculated Molecular Weight
58kDa

Product Categories/Family for anti-ALDH6A1 antibody

Polyclonal
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-ALDH6A1 antibody
Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-ALDH6A1 antibody
WB: 1:500 - 1:2000
IHC: 1:50 - 1:200

Western Blot (WB) of anti-ALDH6A1 antibody

Western blot analysis of extracts of various cell lines, using ALDH6A1 antibody at 1:1000 dilution.
Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (MBS128200) at 1:10000 dilution.
Lysates/proteins: 25ug per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Detection: ECL Basic Kit.
Exposure time: 1s.
Rabbit Anti-ALDH6A1 Polyclonal Antibody – Cat# MBS129898

Other Notes

Small volumes of anti-ALDH6A1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ALDH6A1 purchase

MBS129898 is an antibody targeting ALDH6A1. Also known as ALDH6A1 Polyclonal Antibody. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for ALDH6A1. It may not necessarily be applicable to this product.

NCBI GI #
12643424
NCBI GeneID
4329
NCBI Accession #
Q02252.2
UniProt Primary Accession #
Q02252
UniProt Secondary Accession #
Q9UKM8; B2R609; B4DFS8; J3KNU8
UniProt Related Accession #
Q02252
NCBI Official Full Name
Methylmalonate-semialdehyde dehydrogenase
NCBI Official Synonym Full Names
aldehyde dehydrogenase 6 family, member A1
NCBI Official Symbol
ALDH6A1
NCBI Official Synonym Symbols
MMSDH; MMSADHA
UniProt Protein Name
Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial
UniProt Synonym Protein Names
Aldehyde dehydrogenase family 6 member A1
UniProt Gene Name
ALDH6A1
UniProt Synonym Gene Names
MMSDH; MMSDH; Malonate-semialdehyde dehydrogenase [acylating]
UniProt Entry Name
MMSA_HUMAN
NCBI Protein Information
methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial; methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial; mitochondrial acylating methylmalonate-semialdehyde dehydrogenase

UniProt Comments for ALDH6A1

ALDH6A1: Plays a role in valine and pyrimidine metabolism. Binds fatty acyl-CoA. Defects in ALDH6A1 are the cause of methylmalonate semialdehyde dehydrogenase deficiency (MMSDHD). This is characterized by elevated beta-alanine, 3-hydroxypropionic acid, and both isomers of 3-amino and 3-hydroxyisobutyric acids in urine organic acids. Belongs to the aldehyde dehydrogenase family.

Protein type: Carbohydrate Metabolism - inositol phosphate; EC 1.2.1.27; EC 1.2.1.18; Mitochondrial; Oxidoreductase; Carbohydrate Metabolism - propanoate; Amino Acid Metabolism - valine, leucine and isoleucine degradation

Chromosomal Location of Human Ortholog: 14q24.3

Cellular Component: nucleoplasm; mitochondrion; mitochondrial matrix

Molecular Function: aldehyde dehydrogenase (NAD) activity; acyl-CoA binding; methylmalonate-semialdehyde dehydrogenase (acylating) activity; malonate-semialdehyde dehydrogenase (acetylating) activity

Biological Process: valine catabolic process; thymine metabolic process; brown fat cell differentiation; thymine catabolic process; valine metabolic process; branched chain family amino acid catabolic process

Disease: Methylmalonate Semialdehyde Dehydrogenase Deficiency
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Research Articles on ALDH6A1

1. Mutation analysis in the ALDH6A1 gene can reveal a cause of 3-hydroxyisobutyric aciduria, which may present with only slightly increased urinary levels of 3-hydroxyisobutyric acid, if a patient is metabolically stable [case reports]

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-ALDH6A1 antibody

 Reference Product  PubMed Publications
 ALDH2 antibody  >1 publications with ALDH6A1 and ALDH2
 ALDH1B1 antibody  >1 publications with ALDH6A1 and ALDH1B1
 HIBADH antibody  >1 publications with ALDH6A1 and HIBADH

Pathways associated with anti-ALDH6A1 antibody

 Products by Pathway  Pathway Diagram
 Branched-chain Amino Acid Catabolism Pathway antibodies  Branched-chain Amino Acid Catabolism Pathway Diagram
 Carbon Metabolism Pathway antibodies  Carbon Metabolism Pathway Diagram
 Carbon Metabolism Pathway antibodies  Carbon Metabolism Pathway Diagram
 Inositol Phosphate Metabolism Pathway antibodies  Inositol Phosphate Metabolism Pathway Diagram
 Inositol Phosphate Metabolism Pathway antibodies  Inositol Phosphate Metabolism Pathway Diagram
 Malonate Semialdehyde Pathway, Propanoyl-CoA => Acetyl-CoA antibodies  Malonate Semialdehyde Pathway, Propanoyl-CoA => Acetyl-CoA Diagram
 Malonate Semialdehyde Pathway, Propanoyl-CoA => Acetyl-CoA antibodies  Malonate Semialdehyde Pathway, Propanoyl-CoA => Acetyl-CoA Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Amino Acids And Derivatives Pathway antibodies  Metabolism Of Amino Acids And Derivatives Pathway Diagram

Diseases associated with anti-ALDH6A1 antibody

 Disease Name  Pubmed Publications
 Weight Loss Antibodies  >1 publications with ALDH6A1 and Weight Loss
 Liver Neoplasms Antibodies  >1 publications with ALDH6A1 and Liver Neoplasms
 Liver Diseases Antibodies  >1 publications with ALDH6A1 and Liver Diseases
 Carcinoma, Hepatocellular Antibodies  >1 publications with ALDH6A1 and Carcinoma, Hepatocellular
 Kidney Diseases Antibodies  >1 publications with ALDH6A1 and Kidney Diseases
 Amino Acid Metabolism, Inborn Errors Antibodies  >1 publications with ALDH6A1 and Amino Acid Metabolism, Inborn Errors

Organs/Tissues associated with anti-ALDH6A1 antibody

 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >2 publications with ALDH6A1 and Liver
 Brain Antibodies  >2 publications with ALDH6A1 and Brain
 Vascular Antibodies  >1 publications with ALDH6A1 and Vascular
 Kidney Antibodies  >1 publications with ALDH6A1 and Kidney
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