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Acetyl-Coa Carboxylase 1 (ACACA) Human Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1306882

Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotin-containing enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. There are two ACC forms, alpha and beta,… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Acetyl-CoA carboxylase 1 (ACACA), Recombinant Protein
Full Product Name
Recombinant Human Acetyl-CoA carboxylase 1 (ACACA) , partial
Product Gene Name
ACACA recombinant protein
Product Synonym Gene Name
ACACA
Sequence
PIDRIIEFVP TKTPYDPRWM LAGRPHPTQK GQWLSGFFDY GSFSEIMQPW AQTVVVGRAR LGGIPVGVVA VETRTVELSI PADPANLDSE AKIIQQAGQV WFPDSAFKTY QAIKDFNREG LPLMVFANWR GFSGGMKDMY DQVLKFGAYI VDGLRECCQP VLVYIPPQAE LRGGSWVVID SSINPRHMEM YADRESRGSV LEPEGTVEIK FRRKDLVKTM RRVDPVYIHL AERLGTPELS TAERKELENK LKEREEFLIP IYHQVAVQFA DLHDTPGRMQ EKGVISDILD WKTSRTFFYW RLRRLLLEDL VKKKIHN
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Molecular Weight
269,999 Da
Sequence Positions
1918-2234aa; Partial
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
OMIM
200350
3D Structure
ModBase 3D Structure for Q13085
Species
Human
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of ACACA recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ACACA purchase

MBS1306882 is a recombinant protein targeting ACACA. Also known as Recombinant Human Acetyl-CoA carboxylase 1 (ACACA) , partial. Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for ACACA. It may not necessarily be applicable to this product.

NCBI GI #
38679960
NCBI GeneID
31
NCBI Accession #
NP_942131.1
UniProt Primary Accession #
Q13085
UniProt Secondary Accession #
Q6KEV6; Q6XDA8; Q7Z2G8; Q7Z561; Q7Z563; Q7Z564; Q86WB2; Q86WB3; B2RP68
UniProt Related Accession #
Q13085
GenBank Nucleotide #
NM_198834.2
NCBI Official Full Name
acetyl-CoA carboxylase 1 isoform 1
NCBI Official Synonym Full Names
acetyl-CoA carboxylase alpha
NCBI Official Symbol
ACACA
NCBI Official Synonym Symbols
ACC; ACAC; ACC1; ACCA; ACACAD
UniProt Protein Name
Acetyl-CoA carboxylase 1
UniProt Synonym Protein Names
ACC-alphaIncluding the following 1 domains:Biotin carboxylase (EC:6.3.4.14
UniProt Gene Name
ACACA
UniProt Synonym Gene Names
ACAC; ACC1; ACCA; ACC1
NCBI Protein Information
acetyl-CoA carboxylase 1

NCBI Summary for ACACA

Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotin-containing enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. There are two ACC forms, alpha and beta, encoded by two different genes. ACC-alpha is highly enriched in lipogenic tissues. The enzyme is under long term control at the transcriptional and translational levels and under short term regulation by the phosphorylation/dephosphorylation of targeted serine residues and by allosteric transformation by citrate or palmitoyl-CoA. Multiple alternatively spliced transcript variants divergent in the 5' sequence and encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
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UniProt Comments for ACACA

Catalyzes the rate-limiting reaction in the biogenesis of long-chain fatty acids. Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase.

Research Articles on ACACA

1. Inhibition of Acetyl-CoA Carboxylase 1 (ACC1) and 2 (ACC2) Reduces Proliferation and De Novo Lipogenesis of EGFRvIII Human Glioblastoma Cells

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with ACACA recombinant protein

 Reference Product  PubMed Publications
 PRKAA1 recombinant protein  >2 publications with ACACA and PRKAA1
 PRKAA2 recombinant protein  >1 publications with ACACA and PRKAA2

Pathways associated with ACACA recombinant protein

 Products by Pathway  Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 Activation Of Gene Expression By SREBP (SREBF) Pathway antibodies  Activation Of Gene Expression By SREBP (SREBF) Pathway Diagram
 ChREBP Activates Metabolic Gene Expression Pathway antibodies  ChREBP Activates Metabolic Gene Expression Pathway Diagram
 Fatty Acid Biosynthesis Pathway antibodies  Fatty Acid Biosynthesis Pathway Diagram
 Fatty Acyl-CoA Biosynthesis Pathway antibodies  Fatty Acyl-CoA Biosynthesis Pathway Diagram
 Fatty Acid Biosynthesis Pathway antibodies  Fatty Acid Biosynthesis Pathway Diagram
 Fatty Acid Biosynthesis Pathway antibodies  Fatty Acid Biosynthesis Pathway Diagram
 Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway antibodies  Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway Diagram
 Import Of Palmitoyl-CoA Into The Mitochondrial Matrix Pathway antibodies  Import Of Palmitoyl-CoA Into The Mitochondrial Matrix Pathway Diagram
 Insulin Signaling Pathway antibodies  Insulin Signaling Pathway Diagram

Diseases associated with ACACA recombinant protein

 Disease Name  Pubmed Publications
 Fatty Liver Antibodies  >15 publications with ACACA and Fatty Liver
 Neoplasms Antibodies  >6 publications with ACACA and Neoplasms
 Obesity Antibodies  >6 publications with ACACA and Obesity
 Liver Diseases Antibodies  >4 publications with ACACA and Liver Diseases
 Insulin Resistance Antibodies  >3 publications with ACACA and Insulin Resistance
 Inflammation Antibodies  >3 publications with ACACA and Inflammation
 Hypertriglyceridemia Antibodies  >2 publications with ACACA and Hypertriglyceridemia
 Weight Gain Antibodies  >2 publications with ACACA and Weight Gain
 Hypercholesterolemia Antibodies  >1 publications with ACACA and Hypercholesterolemia
 Hyperlipidemias Antibodies  >1 publications with ACACA and Hyperlipidemias

Organs/Tissues associated with ACACA recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Adipose Tissue Antibodies  >21 publications with ACACA and Adipose Tissue
 Liver Antibodies  >19 publications with ACACA and Liver
 Mammary Gland Antibodies  >16 publications with ACACA and Mammary Gland
 Muscle Antibodies  >14 publications with ACACA and Muscle
 Blood Antibodies  >11 publications with ACACA and Blood
 Connective Tissue Antibodies  >9 publications with ACACA and Connective Tissue
 Vascular Antibodies  >4 publications with ACACA and Vascular
 Brain Antibodies  >4 publications with ACACA and Brain
 Thyroid Antibodies  >3 publications with ACACA and Thyroid
 Pancreas Antibodies  >3 publications with ACACA and Pancreas
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