Sentrin-Specific Protease 8 (SENP8) Human Recombinant Protein

Protease that catalyzes two essential functions in the NEDD8 pathway: processing of full-length NEDD8 to its mature form and deconjugation of NEDD8 from targeted proteins such as cullins or p53.

NEDP1, a highly conserved cysteine protease that deneddylates cullins.Mendoza H.M., Shen L.-N., Botting C., Lewis A., Chen J., Ink B., Hay R.T.J. Biol. Chem. 278:25637-25643(2003) Identification of SENP8, a novel member of the sentrin-specific protease family.Gong L., Yeh E.T.H. Identification of FKSG8, a novel gene encoding a protein with cysteine protease activity.Wang Y.-G. DEN1 is a dual function protease capable of processing the C-terminus of Nedd8 and deconjugating hyper-neddylated CUL1.Wu K., Yamoah K., Dolios G., Gan-Erdene T., Tan P., Chen A., Lee C.-G., Wei N., Wilkinson K.D., Wang R., Pan Z.-Q.J. Biol. Chem. 278:28882-28891(2003) Identification and characterization of DEN1, a deneddylase of the ULP family.Gan-Erdene T., Nagamalleswari K., Yin L., Wu K., Pan Z.-Q., Wilkinson K.D.J. Biol. Chem. 278:28892-28900(2003) Mdm2-mediated NEDD8 conjugation of p53 inhibits its transcriptional activity.Xirodimas D.P., Saville M.K., Bourdon J.-C., Hay R.T., Lane D.P.Cell 118:83-97(2004) Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.Anal. Chem. 81:4493-4501(2009) Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) Structural basis of NEDD8 ubiquitin discrimination by the deneddylating enzyme NEDP1.Shen L.-N., Liu H., Dong C., Xirodimas D.P., Naismith J.H., Hay R.T.EMBO J. 24:1341-1351(2005) Structure of a complex between Nedd8 and the Ulp/Senp protease family member Den1.Reverter D., Wu K., Erdene T.G., Pan Z.-Q., Wilkinson K.D., Lima C.D.J. Mol. Biol. 345:141-151(2005)

Small volumes of SENP8 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS1307410 is a recombinant protein targeting SENP8. Also known as Recombinant Human Sentrin-specific protease 8. Host: E Coli or Yeast or Baculovirus or Mammalian Cell.