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NAD-Dependent Protein Deacylase Sirtuin-5, Mitochondrial (SIRT5) Pongo Abelii Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1308253

MBS1308253 is a recombinant protein targeting SIRT5. Also known as Recombinant Pongo abelii NAD-dependent protein deacylase sirtuin-5, mitochondrial (SIRT5). Host: E Coli or Yeast or Baculovirus or Mammalian Cell. More details

$960 / 0.02 mg (E-Coli) +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
NAD-dependent protein deacylase sirtuin-5, mitochondrial (SIRT5), Recombinant Protein
Full Product Name
Recombinant Pongo abelii NAD-dependent protein deacylase sirtuin-5, mitochondrial (SIRT5)
Product Gene Name
SIRT5 recombinant protein
Product Synonym Gene Name
SIRT5
Sequence
SSSMADFRKL FAKAKHIVIM SGAGVSAESG VPTFRGAGGY WRKWQAQDLA TPLAFAHNPS RVWEFYHYRR EVMGSKEPNA GHRAIAECET RLGKQGRRVV VITQNIDELH RKAGTKNLLE IHGSLFKTRC TSCGVVAENY KSPICPALSG KGAPEPGTQD ASIPIEKLPR CEEAGCGGLL RPHVVWFGEN LDPAILEEVD RELAHCDLCL VVGTSSVVYP AAMFAPQVAA RGVPVAEFNT ETTPATNRFR FHFQGPCGTT LPEALARHEN ETVS
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Molecular Weight
32,031 Da
Sequence Positions
37-310, Full length protein
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
3D Structure
ModBase 3D Structure for Q5R6G3
Species
Pongo abelii (Sumatran orangutan)
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of SIRT5 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for SIRT5. It may not necessarily be applicable to this product.

NCBI GI #
197098318
NCBI GeneID
100173543
NCBI Accession #
NP_001126552.1
UniProt Primary Accession #
Q5R6G3
UniProt Secondary Accession #
Q5RCF2
UniProt Related Accession #
Q5R6G3
GenBank Nucleotide #
NM_001133080.1
NCBI Official Full Name
NAD-dependent protein deacylase sirtuin-5, mitochondrial
NCBI Official Symbol
SIRT5
UniProt Protein Name
NAD-dependent protein deacylase sirtuin-5, mitochondrial
UniProt Synonym Protein Names
Regulatory protein SIR2 homolog 5
Protein Family
NAD-dependent protein deacylase sirtuin
UniProt Gene Name
SIRT5
NCBI Protein Information
NAD-dependent protein deacylase sirtuin-5, mitochondrial

UniProt Comments for SIRT5

NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation and deglutarylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting. Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species (). Modulates ketogenesis through the desuccinylation and activation of HMGCS2 (). Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo. Can deacetylate cytochrome c (CYCS) and a number of other proteins in vitro such as Uox ().
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with SIRT5 recombinant protein

 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >4 publications with SIRT5 and Nervous System Diseases
 Liver Diseases Antibodies  >2 publications with SIRT5 and Liver Diseases
 Fatty Liver Antibodies  >2 publications with SIRT5 and Fatty Liver
 Carcinoma, Hepatocellular Antibodies  >2 publications with SIRT5 and Carcinoma, Hepatocellular
 Lung Diseases Antibodies  >1 publications with SIRT5 and Lung Diseases
 Heart Diseases Antibodies  >1 publications with SIRT5 and Heart Diseases
 Adenocarcinoma Antibodies  >1 publications with SIRT5 and Adenocarcinoma
 Abnormalities, Drug-Induced Antibodies  >1 publications with SIRT5 and Abnormalities, Drug-Induced
 Kidney Diseases Antibodies  >1 publications with SIRT5 and Kidney Diseases
 Insulin Resistance Antibodies  >1 publications with SIRT5 and Insulin Resistance

Organs/Tissues associated with SIRT5 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Heart Antibodies  >6 publications with SIRT5 and Heart
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