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PRKCA-Binding Protein (PICK1) Bovine Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1310746

This protein contains a PDZ domain, through which it interacts with protein kinase C, alpha (PRKCA). This protein may function as an adaptor that binds to and organizes the subcellular localization of a variety of membrane proteins. It has been shown to… More details

$1160 / 0.02 mg (E-Coli) +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
PRKCA-binding protein (PICK1), Recombinant Protein
Full Product Name
Recombinant Bovine PRKCA-binding protein (PICK1)
Product Gene Name
PICK1 recombinant protein
Product Synonym Gene Name
PICK1
Sequence
MFADLGYDIE EDKLGIPTVP GKVTLQKDAQ NLIGISIGGG AQYCPCLYIV QVFDNTPAAL DGTVAAGDEI TGVNGRSIKG KTKVEVAKMI QEVKGEVTIH YNKLQADPKQ GMSLDIVLKK VKHRLVENMS SGTADALGLS RAILCNDGLV KRLEELERTA ELYKGMTEHT KNLLRAFYEL SQTHRAFGDV FSVIGVREPQ PAASEAFVKF ADAHRSIEKF GIRLLKTIKP MLTDLNTYLN KAIPDTRLTI KKYLDVKFEY LSYCLKVKEM DDEEYSCIAL GEPLYRVSTG NYEYRLILRC RQEARARFSQ MRKDVLEKME LLDQEHVQDI VLQLQRFVST MSKYYNDCYS VLRDADVFPI EVDLAHTTLA YGLSQDEFTD GEDEEDEDEE DTAAGEPPRD SRGAAGPLDK GGSWCNS
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Molecular Weight
46,729 Da
Sequence Positions
1-417, full length protein
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
3D Structure
ModBase 3D Structure for Q2T9M1
Species
Bovine
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of PICK1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PICK1 purchase

MBS1310746 is a recombinant protein targeting PICK1. Also known as Recombinant Bovine PRKCA-binding protein (PICK1). Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for PICK1. It may not necessarily be applicable to this product.

NCBI GI #
122136937
NCBI GeneID
533737
NCBI Accession #
Q2T9M1.1
UniProt Primary Accession #
Q2T9M1
UniProt Related Accession #
Q2T9M1
NCBI Official Full Name
PRKCA-binding protein
NCBI Official Synonym Full Names
protein interacting with PRKCA 1
NCBI Official Symbol
PICK1
UniProt Protein Name
PRKCA-binding protein
UniProt Synonym Protein Names
Protein interacting with C kinase 1; Protein kinase C-alpha-binding protein
Protein Family
PRKCA-binding protein
UniProt Gene Name
PICK1
UniProt Synonym Gene Names
PRKCABP
NCBI Protein Information
PRKCA-binding protein

UniProt Comments for PICK1

Probable adapter protein that bind to and organize the subcellular localization of a variety of membrane proteins containing some PDZ recognition sequence. Involved in the clustering of various receptors, possibly by acting at the receptor internalization level. Plays a role in synaptic plasticity by regulating the trafficking and internalization of AMPA receptors. May be regulated upon PRKCA activation. May regulate ASIC1/ASIC3 channel. Regulates actin polymerization by inhibiting the actin-nucleating activity of the Arp2/3 complex; the function is competetive with nucleation promoting factors and is linked to neuronal morphology regulation and AMPA receptor (AMPAR) endocytosis. Via interaction with the Arp2/3 complex involved in regulation of synaptic plasicity of excitatory synapses and required for spine shrinkage during long-term depression (LTD). Involved in regulation of astrocyte morphology, antagonistic to Arp2/3 complex activator WASL/N-WASP function ().
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with PICK1 recombinant protein

 Reference Product  PubMed Publications
 GRIP1 recombinant protein  >27 publications with PICK1 and GRIP1
 GRIP2 recombinant protein  >8 publications with PICK1 and GRIP2
 ACCN2 recombinant protein  >8 publications with PICK1 and ACCN2
 SLC6A2 recombinant protein  >2 publications with PICK1 and SLC6A2

Pathways associated with PICK1 recombinant protein

 Products by Pathway  Pathway Diagram
 Glutamate Binding, Activation Of AMPA Receptors And Synaptic Plasticity Pathway antibodies  Glutamate Binding, Activation Of AMPA Receptors And Synaptic Plasticity Pathway Diagram
 Neuronal System Pathway antibodies  Neuronal System Pathway Diagram
 Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Pathway antibodies  Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Pathway Diagram
 Trafficking Of AMPA Receptors Pathway antibodies  Trafficking Of AMPA Receptors Pathway Diagram
 Trafficking Of GluR2-containing AMPA Receptors Pathway antibodies  Trafficking Of GluR2-containing AMPA Receptors Pathway Diagram
 Transmission Across Chemical Synapses Pathway antibodies  Transmission Across Chemical Synapses Pathway Diagram

Organs/Tissues associated with PICK1 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >97 publications with PICK1 and Brain
 Kidney Antibodies  >6 publications with PICK1 and Kidney
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