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COP9 Signalosome Complex Subunit 4 (COPS4) Human Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1311649

This gene encodes one of eight subunits composing COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S… More details

$1145 / 0.02 mg (E-Coli) +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
COP9 signalosome complex subunit 4 (COPS4), Recombinant Protein
Full Product Name
Recombinant Human COP9 signalosome complex subunit 4 (COPS4)
Product Gene Name
COPS4 recombinant protein
Product Synonym Gene Name
COPS4
Sequence
AAAVRQDLAQ LMNSSGSHKD LAGKYRQILE KAIQLSGAEQ LEALKAFVEA MVNENVSLVI SRQLLTDFCT HLPNLPDSTA KEIYHFTLEK IQPRVISFEE QVASIRQHLA SIYEKEEDWR NAAQVLVGIP LETGQKQYNV DYKLETYLKI ARLYLEDDDP VQAEAYINRA SLLQNESTNE QLQIHYKVCY ARVLDYRRKF IEAAQRYNEL SYKTIVHESE RLEALKHALH CTILASAGQQ RSRMLATLFK DERCQQLAAY GILEKMYLDR IIRGNQLQEF AAMLMPHQKA TTADGSSILD RAVIEHNLLS ASKLYNNITF EELGALLEIP AAKAEKIASQ MITEGRMNGF IDQIDGIVHF ETREALPTWD KQIQSLCFQV NNLLEKISQT APEWTAQAME AQMAQ
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Molecular Weight
40,197 Da
Sequence Positions
2-406, Full length protein
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
OMIM
616008
3D Structure
ModBase 3D Structure for Q9BT78
Species
Human
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of COPS4 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for COPS4 purchase

MBS1311649 is a recombinant protein targeting COPS4. Also known as Recombinant Human COP9 signalosome complex subunit 4 (COPS4). Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for COPS4. It may not necessarily be applicable to this product.

NCBI GI #
384367993
NCBI GeneID
51138
NCBI Accession #
NP_001244935.1
UniProt Primary Accession #
Q9BT78
UniProt Secondary Accession #
Q561W7; Q9NW31; Q9Y677; B3KN88; B3KST5
UniProt Related Accession #
Q9BT78
GenBank Nucleotide #
NM_001258006.1
NCBI Official Full Name
COP9 signalosome complex subunit 4 isoform 2
NCBI Official Synonym Full Names
COP9 signalosome subunit 4
NCBI Official Symbol
COPS4
NCBI Official Synonym Symbols
CSN4; SGN4
UniProt Protein Name
COP9 signalosome complex subunit 4
UniProt Synonym Protein Names
JAB1-containing signalosome subunit 4
UniProt Gene Name
COPS4
UniProt Synonym Gene Names
CSN4; SGN4; Signalosome subunit 4
NCBI Protein Information
COP9 signalosome complex subunit 4

NCBI Summary for COPS4

This gene encodes one of eight subunits composing COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]
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UniProt Comments for COPS4

Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. Also involved in the deneddylation of non-cullin subunits such as STON2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1, IRF8/ICSBP and SNAPIN, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.
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Research Articles on COPS4

1. CSN4 silencing decreases CSN5 protein levels and suggest that the CSN4 effects on sGCA1 and p53 proteins are mediated by CSN5.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with COPS4 recombinant protein

 Reference Product  PubMed Publications
 COPS2 recombinant protein  >1 publications with COPS4 and COPS2
 COPS6 recombinant protein  >1 publications with COPS4 and COPS6
 COPS5 recombinant protein  >1 publications with COPS4 and COPS5

Diseases associated with COPS4 recombinant protein

 Disease Name  Pubmed Publications
 Prostatic Diseases Antibodies  >1 publications with COPS4 and Prostatic Diseases

Organs/Tissues associated with COPS4 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Prostate Antibodies  >1 publications with COPS4 and Prostate
 Brain Antibodies  >1 publications with COPS4 and Brain
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