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Glypican-6 (GPC6) (GPC6\r) Human Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1312042

The glypicans comprise a family of glycosylphosphatidylinositol-anchored heparan sulfate proteoglycans, and they have been implicated in the control of cell growth and cell division. The glypican encoded by this gene is a putative cell surface coreceptor for… More details

$1310 / 0.02 mg (E-Coli) +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Glypican-6 (GPC6) (GPC6\r), Recombinant Protein
Full Product Name
Recombinant Human Glypican-6 (GPC6)
Product Gene Name
GPC6\r recombinant protein
Product Synonym Gene Name
GPC6
Sequence
DVKARSCGEV RQAYGAKGFS LADIPYQEIA GEHLRICPQE YTCCTTEMED KLSQQSKLEF ENLVEETSHF VRTTFVSRHK KFDEFFRELL ENAEKSLNDM FVRTYGMLYM QNSEVFQDLF TELKRYYTGG NVNLEEMLND FWARLLERMF QLINPQYHFS EDYLECVSKY TDQLKPFGDV PRKLKIQVTR AFIAARTFVQ GLTVGREVAN RVSKVSPTPG CIRALMKMLY CPYCRGLPTV RPCNNYCLNV MKGCLANQAD LDTEWNLFID AMLLVAERLE GPFNIESVMD PIDVKISEAI MNMQENSMQV SAKVFQGCGQ PKPAPALRSA RSAPENFNTR FRPYNPEERP TTAAGTSLDR LVTDIKEKLK LSKKVWSALP YTICKDESVT AGTSNEEECW NGHSKARYLP EIMNDGLTNQ INNPEVDVDI TRPDTFIRQQ IMALRVMTNK LKNAYNGNDV NFQDTSDESS GSGSGSGCMD DVCPTEFEFV TTEAPAVDPD RREVDS
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Molecular Weight
62,736 Da
Sequence Positions
24-529, Full length protein
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
OMIM
258315
3D Structure
ModBase 3D Structure for Q9Y625
Species
Human
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of GPC6\r recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for GPC6\r purchase

MBS1312042 is a recombinant protein targeting GPC6\r. Also known as Recombinant Human Glypican-6 (GPC6). Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for GPC6\r. It may not necessarily be applicable to this product.

NCBI GI #
5031719
NCBI GeneID
10082
NCBI Accession #
NP_005699.1
UniProt Primary Accession #
Q9Y625
UniProt Secondary Accession #
Q96SG5; Q96SG8; Q9H1P4; A8K279
UniProt Related Accession #
Q9Y625
GenBank Nucleotide #
NM_005708.4
NCBI Official Full Name
glypican-6
NCBI Official Synonym Full Names
glypican 6
NCBI Official Symbol
GPC6
NCBI Official Synonym Symbols
OMIMD1
UniProt Protein Name
Glypican-6
UniProt Gene Name
GPC6
NCBI Protein Information
glypican-6

NCBI Summary for GPC6\r

The glypicans comprise a family of glycosylphosphatidylinositol-anchored heparan sulfate proteoglycans, and they have been implicated in the control of cell growth and cell division. The glypican encoded by this gene is a putative cell surface coreceptor for growth factors, extracellular matrix proteins, proteases and anti-proteases. Mutations in this gene are associated with omodysplasia 1. [provided by RefSeq, Nov 2016]
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UniProt Comments for GPC6\r

Cell surface proteoglycan that bears heparan sulfate. Putative cell surface coreceptor for growth factors, extracellular matrix proteins, proteases and anti-proteases (). Enhances migration and invasion of cancer cells through WNT5A signaling.

Research Articles on GPC6\r

1. Thus, GPC6 and TMEM132D may serve as predictors of CD8+ T-lymphocyte infiltration and as favorable prognostic markers in early stage ovarian cancer with important consequences for diagnosis.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with GPC6\r recombinant protein

 Reference Product  PubMed Publications
 GPC3 recombinant protein  >26 publications with GPC6\r and GPC3
 GPC5 recombinant protein  >9 publications with GPC6\r and GPC5
 SDC2 recombinant protein  >3 publications with GPC6\r and SDC2
 SDC1 recombinant protein  >2 publications with GPC6\r and SDC1
 NDST1 recombinant protein  >2 publications with GPC6\r and NDST1
 VCAN recombinant protein  >1 publications with GPC6\r and VCAN
 NDST2 recombinant protein  >1 publications with GPC6\r and NDST2
 SDC4 recombinant protein  >1 publications with GPC6\r and SDC4
 SDC3 recombinant protein  >1 publications with GPC6\r and SDC3

Pathways associated with GPC6\r recombinant protein

 Products by Pathway  Pathway Diagram
 A Tetrasaccharide Linker Sequence Is Required For GAG Synthesis Pathway antibodies  A Tetrasaccharide Linker Sequence Is Required For GAG Synthesis Pathway Diagram
 Chondroitin Sulfate/dermatan Sulfate Metabolism Pathway antibodies  Chondroitin Sulfate/dermatan Sulfate Metabolism Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Diseases Associated With Visual Transduction Pathway antibodies  Diseases Associated With Visual Transduction Pathway Diagram
 Glycogen Storage Diseases Pathway antibodies  Glycogen Storage Diseases Pathway Diagram
 Glycosaminoglycan Metabolism Pathway antibodies  Glycosaminoglycan Metabolism Pathway Diagram
 HS-GAG Biosynthesis Pathway antibodies  HS-GAG Biosynthesis Pathway Diagram
 HS-GAG Degradation Pathway antibodies  HS-GAG Degradation Pathway Diagram
 Heparan Sulfate/heparin (HS-GAG) Metabolism Pathway antibodies  Heparan Sulfate/heparin (HS-GAG) Metabolism Pathway Diagram
 MPS I - Hurler Syndrome Pathway antibodies  MPS I - Hurler Syndrome Pathway Diagram

Diseases associated with GPC6\r recombinant protein

 Disease Name  Pubmed Publications
 Breast Neoplasms Antibodies  >2 publications with GPC6\r and Breast Neoplasms
 Carcinoma, Hepatocellular Antibodies  >2 publications with GPC6\r and Carcinoma, Hepatocellular
 Adenocarcinoma Antibodies  >1 publications with GPC6\r and Adenocarcinoma
 Neural Tube Defects Antibodies  >1 publications with GPC6\r and Neural Tube Defects
 Liver Neoplasms Antibodies  >1 publications with GPC6\r and Liver Neoplasms
 Pancreatic Neoplasms Antibodies  >1 publications with GPC6\r and Pancreatic Neoplasms
 Liver Diseases Antibodies  >1 publications with GPC6\r and Liver Diseases
 Inflammation Antibodies  >1 publications with GPC6\r and Inflammation
 Neoplasm Metastasis Antibodies  >1 publications with GPC6\r and Neoplasm Metastasis
 Rhabdomyosarcoma Antibodies  >1 publications with GPC6\r and Rhabdomyosarcoma

Organs/Tissues associated with GPC6\r recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >6 publications with GPC6\r and Bone
 Intestine Antibodies  >2 publications with GPC6\r and Intestine
 Muscle Antibodies  >2 publications with GPC6\r and Muscle
 Liver Antibodies  >2 publications with GPC6\r and Liver
 Kidney Antibodies  >2 publications with GPC6\r and Kidney
 Ovary Antibodies  >2 publications with GPC6\r and Ovary
 Prostate Antibodies  >1 publications with GPC6\r and Prostate
 Eye Antibodies  >1 publications with GPC6\r and Eye
 Lung Antibodies  >1 publications with GPC6\r and Lung
 Vascular Antibodies  >1 publications with GPC6\r and Vascular
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