SRF: a transcription factor of the MADS domain family that binds to the serum response element (SRE). Regulates the transcription of immediate early genes including c-fos. Binds DNA as a multimer, probably a dimer.
Protein type: Motility/polarity/chemotaxis; Transcription factor
Cellular Component: cytoplasm; nuclear chromatin; nucleus
Molecular Function: chromatin binding; chromatin DNA binding; DNA binding; histone deacetylase binding; protein binding; protein dimerization activity; protein homodimerization activity; RNA polymerase II transcription factor activity, enhancer binding; sequence-specific DNA binding; transcription factor activity; transcription factor binding
Biological Process: actin cytoskeleton organization and biogenesis; actin filament organization; associative learning; cardiac myofibril assembly; cell migration during sprouting angiogenesis; cell-cell adhesion; cell-matrix adhesion; contractile actin filament bundle formation; developmental growth; erythrocyte development; gastrulation; heart development; heart looping; hippocampus development; in utero embryonic development; leukocyte differentiation; long-term memory; mesoderm formation; morphogenesis of an epithelial sheet; mRNA transcription from RNA polymerase II promoter; multicellular organismal development; muscle maintenance; negative regulation of cell migration; negative regulation of cell proliferation; neurite development; neuron migration; patterning of blood vessels; platelet activation; platelet formation; positive regulation of axon extension; positive regulation of cell differentiation; positive regulation of filopodium formation; positive regulation of smooth muscle contraction; positive regulation of transcription by glucose; positive regulation of transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; positive thymic T cell selection; regulation of cell adhesion; regulation of transcription, DNA-dependent; regulation of water loss via skin; response to cytokine stimulus; response to hormone stimulus; sarcomere organization; skin morphogenesis; stress fiber formation; tangential migration from the subventricular zone to the olfactory bulb; thymus development; thyroid gland development; transcription from RNA polymerase II promoter; transcription, DNA-dependent; trophectodermal cell differentiation
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