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Zinc Finger Protein Gfi-1 (GFI1) Human Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1314619

This gene encodes a nuclear zinc finger protein that functions as a transcriptional repressor. This protein plays a role in diverse developmental contexts, including hematopoiesis and oncogenesis. It functions as part of a complex along with other cofactors… More details

$1165 / 0.02 mg (E-Coli) +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Zinc finger protein Gfi-1 (GFI1), Recombinant Protein
Full Product Name
Recombinant Human Zinc finger protein Gfi-1 (GFI1)
Product Gene Name
GFI1 recombinant protein
Product Synonym Gene Name
GFI1
Sequence
MPRSFLVKSK KAHSYHQPRS PGPDYSLRLE NVPAPSRADS TSNAGGAKAE PRDRLSPESQ LTEAPDRASA SPDSCEGSVC ERSSEFEDFW RPPSPSASPA SEKSMCPSLD EAQPFPLPFK PYSWSGLAGS DLRHLVQSYR PCGALERGAG LGLFCEPAPE PGHPAALYGP KRAAGGAGAG APGSCSAGAG ATAGPGLGLY GDFGSAAAGL YERPTAAAGL LYPERGHGLH ADKGAGVKVE SELLCTRLLL GGGSYKCIKC SKVFSTPHGL EVHVRRSHSG TRPFACEMCG KTFGHAVSLE QHKAVHSQER SFDCKICGKS FKRSSTLSTH LLIHSDTRPY PCQYCGKRFH QKSDMKKHTF IHTGEKPHKC QVCGKAFSQS SNLITHSRKH TGFKPFGCDL CGKGFQRKVD LRRHRETQHG LK
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Molecular Weight
45,297 Da
Sequence Positions
1-422, Full length protein
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
OMIM
600871
3D Structure
ModBase 3D Structure for Q99684
Species
Human
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of GFI1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for GFI1 purchase

MBS1314619 is a recombinant protein targeting GFI1. Also known as Recombinant Human Zinc finger protein Gfi-1 (GFI1). Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for GFI1. It may not necessarily be applicable to this product.

NCBI GI #
187761349
NCBI GeneID
2672
NCBI Accession #
NP_001120687.1
UniProt Primary Accession #
Q99684
UniProt Secondary Accession #
Q8N564
UniProt Related Accession #
Q99684
GenBank Nucleotide #
NM_001127215.2
NCBI Official Full Name
zinc finger protein Gfi-1
NCBI Official Synonym Full Names
growth factor independent 1 transcriptional repressor
NCBI Official Symbol
GFI1
NCBI Official Synonym Symbols
SCN2; GFI-1; GFI1A; ZNF163
UniProt Protein Name
Zinc finger protein Gfi-1
UniProt Synonym Protein Names
Growth factor independent protein 1; Zinc finger protein 163
Protein Family
Zinc finger protein
UniProt Gene Name
GFI1
UniProt Synonym Gene Names
ZNF163
NCBI Protein Information
zinc finger protein Gfi-1

UniProt Comments for GFI1

Transcription repressor essential for hematopoiesis. Functions in a cell-context and development-specific manner. Binds to 5'-TAAATCAC[AT]GCA-3' in the promoter region of a large number of genes. Component of several complexes, including the EHMT2-GFI1-HDAC1, AJUBA-GFI1-HDAC1 and RCOR-GFI-KDM1A-HDAC complexes, that suppress, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. Regulates neutrophil differentiation, promotes proliferation of lymphoid cells, and is required for granulocyte development. Mediates, together with U2AF1L4, the alternative splicing of CD45 and controls T-cell receptor signaling. Regulates the endotoxin-mediated Toll-like receptor (TLR) inflammatory response by antagonizing RELA. Cooperates with CBFA2T2 to regulate ITGB1-dependent neurite growth. Controls cell-cycle progression by repressing CDKNIA/p21 transcription in response to TGFB1 via recruitment of GFI1 by ZBTB17 to the CDKNIA/p21 and CDKNIB promoters. Required for the maintenance of inner ear hair cells.
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Research Articles on GFI1

1. GFI1 downregulation promotes inflammation-linked metastasis of colorectal cancer.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with GFI1 recombinant protein

 Reference Product  PubMed Publications
 MYC recombinant protein  >14 publications with GFI1 and MYC
 CDKN1A recombinant protein  >6 publications with GFI1 and CDKN1A
 CBFA2T3 recombinant protein  >2 publications with GFI1 and CBFA2T3
 KDM1A recombinant protein  >1 publications with GFI1 and KDM1A
 RCOR1 recombinant protein  >1 publications with GFI1 and RCOR1
 MAX recombinant protein  >1 publications with GFI1 and MAX
 SPI1 recombinant protein  >1 publications with GFI1 and SPI1
 ZBTB17 recombinant protein  >1 publications with GFI1 and ZBTB17

Pathways associated with GFI1 recombinant protein

 Products by Pathway  Pathway Diagram
 Validated Targets Of C-MYC Transcriptional Repression Pathway antibodies  Validated Targets Of C-MYC Transcriptional Repression Pathway Diagram

Diseases associated with GFI1 recombinant protein

 Disease Name  Pubmed Publications
 Hematologic Diseases Antibodies  >45 publications with GFI1 and Hematologic Diseases
 Lymphoma Antibodies  >28 publications with GFI1 and Lymphoma
 Leukemia, Myeloid, Acute Antibodies  >15 publications with GFI1 and Leukemia, Myeloid, Acute
 Inflammation Antibodies  >9 publications with GFI1 and Inflammation
 Carcinoma Antibodies  >8 publications with GFI1 and Carcinoma
 Necrosis Antibodies  >8 publications with GFI1 and Necrosis
 Congenital Abnormalities Antibodies  >5 publications with GFI1 and Congenital Abnormalities
 Precursor Cell Lymphoblastic Leukemia-Lymphoma Antibodies  >5 publications with GFI1 and Precursor Cell Lymphoblastic Leukemia-Lymphoma
 Lung Neoplasms Antibodies  >4 publications with GFI1 and Lung Neoplasms
 Neoplasms, Experimental Antibodies  >4 publications with GFI1 and Neoplasms, Experimental

Organs/Tissues associated with GFI1 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >121 publications with GFI1 and Blood
 Bone Marrow Antibodies  >43 publications with GFI1 and Bone Marrow
 Thymus Antibodies  >15 publications with GFI1 and Thymus
 Lung Antibodies  >14 publications with GFI1 and Lung
 Spleen Antibodies  >9 publications with GFI1 and Spleen
 Intestine Antibodies  >8 publications with GFI1 and Intestine
 Pancreas Antibodies  >3 publications with GFI1 and Pancreas
 Lymph Node Antibodies  >1 publications with GFI1 and Lymph Node
 Uncharacterized Tissue Antibodies  >1 publications with GFI1 and Uncharacterized Tissue
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