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Katanin P80 WD40-Containing Subunit B1 (KATNB1) Mouse Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1315424

Microtubules, polymers of alpha and beta tubulin subunits, form the mitotic spindle of a dividing cell and help to organize membranous organelles during interphase. Katanin is a heterodimer that consists of a 60 kDa ATPase (p60 subunit A 1) and an 80 kDa… More details

$1475 / 0.02 mg (E-Coli) +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Katanin p80 WD40-containing subunit B1 (Katnb1), Recombinant Protein
Full Product Name
Recombinant Mouse Katanin p80 WD40-containing subunit B1 (Katnb1)
Product Gene Name
Katnb1 recombinant protein
Product Synonym Gene Name
Katnb1
Sequence
MATPVVTKTA WKLQEIVAHA SNVSSLVLGK ASGRLLATGG DDCRVNLWSI NKPNCIMSLT GHTSPVESVR LNTPEELIVA GSQSGSIRVW DLEAAKILRT LMGHKANICS LDFHPYGEFV ASGSQDTNIK LWDIRRKGCV FRYRGHSQAV RCLRFSPDGK WLASAADDHT VKLWDLTAGK MMSEFPGHTG PVNVVEFHPN EYLLASGSSD RTIRFWDLEK FQVVSCIEGE PGPVRSVLFN PDGCCLYSGC QDSLRVYGWE PERCFDVVLV NWGKVADLAI CNDQLIGVAF SQSNVSSYVV DLTRVTRTGT VTQDPVQANQ PLTQQTPNPG VSLRRIYERP STTCSKPQRV KHNSESERRS PSSEDDRDER ESRAEIQNAE DYNEIFQPKN SISRTPPRRS EPFPAPPEDD AATVKEVSKP SPAMDVQLPQ LPVPNLEVPA RPSVMTSTPA PKGEPDIIPA TRNEPIGLKA SDFLPAVKVP QQAELVDEDA MSQIRKGHDT MFVVLTSRHK NLDTVRAVWT TGDIKTSVDS AVAINDLSVV VDLLNIVNQK ASLWKLDLCT TVLPQIEKLL QSKYESYVQT GCTSLKLILQ RFLPLITDIL AAPPSVGVDI SREERLHKCR LCFKQLKSIS GLVKSKSGLS GRHGSAFREL HLLMASLD
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Molecular Weight
72,639 Da
Sequence Positions
1-658, Full length protein
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
3D Structure
ModBase 3D Structure for Q8BG40
Species
Mouse
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of Katnb1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Katnb1 purchase

MBS1315424 is a recombinant protein targeting Katnb1. Also known as Recombinant Mouse Katanin p80 WD40-containing subunit B1 (Katnb1). Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for Katnb1. It may not necessarily be applicable to this product.

NCBI GI #
84095201
NCBI GeneID
74187
NCBI Accession #
NP_083081.2
UniProt Primary Accession #
Q8BG40
UniProt Secondary Accession #
Q8CD18; Q8R1J0; Q9CWV2
UniProt Related Accession #
Q8BG40
GenBank Nucleotide #
NM_028805.2
NCBI Official Full Name
katanin p80 WD40 repeat-containing subunit B1
NCBI Official Synonym Full Names
katanin p80 (WD40-containing) subunit B 1
NCBI Official Symbol
Katnb1
NCBI Official Synonym Symbols
KAT; 2410003J24Rik
UniProt Protein Name
Katanin p80 WD40 repeat-containing subunit B1
UniProt Synonym Protein Names
p80 katanin
Protein Family
Katanin p80 WD40 repeat-containing
UniProt Gene Name
Katnb1
UniProt Synonym Gene Names
Katanin p80 subunit B1
NCBI Protein Information
katanin p80 WD40 repeat-containing subunit B1

UniProt Comments for Katnb1

Participates in a complex which severs microtubules in an ATP-dependent manner. May act to target the enzymatic subunit of this complex to sites of action such as the centrosome. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. The function in regulating microtubule dynamics at spindle poles seems to depend on the association of the katanin KATNA1:KATNB1 complex with ASPM which recruits it to microtubules. Reversely KATNA1:KATNB1 can enhance ASPM blocking activity on microtubule minus-end growth. Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins. This transport is required for axonal growth.
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Research Articles on Katnb1

1. Collectively these data demonstrate that katanin p80 serves an essential and evolutionarily conserved role in several aspects of male germ cell development

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with Katnb1 recombinant protein

 Disease Name  Pubmed Publications
 Bipolar Disorder Antibodies  >1 publications with Katnb1 and Bipolar Disorder
 Mental Disorders Antibodies  >1 publications with Katnb1 and Mental Disorders

Organs/Tissues associated with Katnb1 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >1 publications with Katnb1 and Brain
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