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Cyclin A1 (CCNA1) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS9600081

Description: CCNA1 May be involved in the control of the cell cycle at the G1/S (start) and G2/M (mitosis) transitions. May primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some… More details

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Product Overview

Online Datasheet in PDF
Product Name
Cyclin A1 (CCNA1), Polyclonal Antibody
Full Product Name
Cyclin A1 Antibody
Product Gene Name
anti-CCNA1 antibody
Product Synonym Names
CCN A1; CCNA 1; Ccna1; CCNA1_HUMAN; Cyclin-A1; CyclinA1; G2/mitotic specific cyclin A1; MGC132235; MGC159139
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
Liquid
Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purity/Purification
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin.
Concentration
1mg/ml (lot specific)
Specificity
Cyclin A1 antibody detects endogenous levels of total Cyclin A1
Preparation and Storage
Store at -20 degree C. Stable for 12 months from date of receipt.
Antibody/Peptide Pairs
Cyclin A1 peptide (MBS9614633) is used for blocking the activity of Cyclin A1 antibody (MBS9600081)
Molecular Weight
Observed: 52 kDa
Predicted: 53 kDa
3D Structure
ModBase 3D Structure for P78396
Supply Chain Verification
Manufactured in a lab with traceable raw materials manufactured on site. Coordinated product portfolio of antibodies, pairs, conjugates, recombinant proteins, and immunoassay materials available, please inquire.
Immunogen
A synthesized peptide derived from human Cyclin A1
Subcellular Location
Nucleus.
Tissue Specificity
Very high levels in testis and very low levels in brain. Also found in myeloid leukemia cell lines.
Conjugation
Unconjugated
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-CCNA1 antibody
Western Blot (WB), Immunohistochemisty (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC), ELISA (EIA)
Application Notes for anti-CCNA1 antibody
WB: 1:500-1:3000
IHC: 1:50-1:200
IF/ICC: 1:100-1:500

Western Blot (WB) of anti-CCNA1 antibody

Western blot analysis on SK-OV3 cell lysate using Cyclin A1 Antibody, The lane on the left is treated with the antigen-specific peptide.
Rabbit Anti-CCNA1 Polyclonal Antibody – Cat# MBS9600081

Immunohistochemistry (IHC) of anti-CCNA1 antibody

MBS9600081 at 1/200 staining human testis tissue sections by IHC-P. The tissue was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The tissue was then blocked and incubated with the antibody for 1.5 hours at 22 degree C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
Rabbit Anti-CCNA1 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS9600081

Product References and Citations for anti-CCNA1 antibody

Yuan Y, Xi Y, Chen J, Zhu P, Kang J, Zou Z, Wang F, Bu S; Journal: Biochem Biophys Res Commun. STAT3 stimulates adipogenic stem cell proliferation and cooperates with HMGA2 during the early stage of differentiation to promote adipogenesis.

Other Notes

Small volumes of anti-CCNA1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CCNA1 purchase

MBS9600081 is an antibody targeting CCNA1. Also known as Cyclin A1 Antibody. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for CCNA1. It may not necessarily be applicable to this product.

NCBI GI #
161377468
NCBI GeneID
8900
NCBI Accession #
NP_001104515.1
UniProt Primary Accession #
P78396
UniProt Secondary Accession #
Q5T3V0; Q5U0G2; Q8IY91; B7Z7E3
UniProt Related Accession #
P78396
GenBank Nucleotide #
NM_001111045.1
NCBI Official Full Name
cyclin-A1 isoform b
NCBI Official Synonym Full Names
cyclin A1
NCBI Official Symbol
CCNA1
NCBI Official Synonym Symbols
CT146
UniProt Protein Name
Cyclin-A1
Protein Family
Cyclin
UniProt Gene Name
CCNA1
NCBI Protein Information
cyclin-A1

NCBI Summary for CCNA1

The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. The cyclin encoded by this gene was shown to be expressed in testis and brain, as well as in several leukemic cell lines, and is thought to primarily function in the control of the germline meiotic cell cycle. This cyclin binds both CDK2 and CDC2 kinases, which give two distinct kinase activities, one appearing in S phase, the other in G2, and thus regulate separate functions in cell cycle. This cyclin was found to bind to important cell cycle regulators, such as Rb family proteins, transcription factor E2F-1, and the p21 family proteins. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
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UniProt Comments for CCNA1

May be involved in the control of the cell cycle at the G1/S (start) and G2/M (mitosis) transitions. May primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells.

Research Articles on CCNA1

1. Thus, Cyclin A/Cdk1 phosphorylation primes MYPT1 for Plk1 binding. These data demonstrate cross-regulation between Cyclin A/Cdk1-dependent and Plk1-dependent phosphorylation of substrates during mitosis to ensure efficient correction of kinetochore microtubule attachment errors necessary for high mitotic fidelity.
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CCNA1 antibody

 Reference Product  PubMed Publications
 CDK2 antibody  >18 publications with CCNA1 and CDK2
 CDKN1A antibody  >7 publications with CCNA1 and CDKN1A
 CDK1 antibody  >5 publications with CCNA1 and CDK1
 CDC25A antibody  >4 publications with CCNA1 and CDC25A
 CDKN1B antibody  >3 publications with CCNA1 and CDKN1B
 E2F1 antibody  >2 publications with CCNA1 and E2F1
 BRCA1 antibody  >2 publications with CCNA1 and BRCA1
 PROCA1 antibody  >1 publications with CCNA1 and PROCA1
 KLHDC9 antibody  >1 publications with CCNA1 and KLHDC9
 INCA1 antibody  >1 publications with CCNA1 and INCA1

Pathways associated with anti-CCNA1 antibody

 Products by Pathway  Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 APC/C-mediated Degradation Of Cell Cycle Proteins Pathway antibodies  APC/C-mediated Degradation Of Cell Cycle Proteins Pathway Diagram
 Acute Myeloid Leukemia Pathway antibodies  Acute Myeloid Leukemia Pathway Diagram
 Acute Myeloid Leukemia Pathway antibodies  Acute Myeloid Leukemia Pathway Diagram
 C-MYB Transcription Factor Network Pathway antibodies  C-MYB Transcription Factor Network Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle, Mitotic Pathway antibodies  Cell Cycle, Mitotic Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram

Diseases associated with anti-CCNA1 antibody

 Disease Name  Pubmed Publications
 Carcinoma, Squamous Cell Antibodies  >21 publications with CCNA1 and Carcinoma, Squamous Cell
 Cell Transformation, Neoplastic Antibodies  >10 publications with CCNA1 and Cell Transformation, Neoplastic
 Neoplasms, Experimental Antibodies  >8 publications with CCNA1 and Neoplasms, Experimental
 Lung Neoplasms Antibodies  >6 publications with CCNA1 and Lung Neoplasms
 Lung Diseases Antibodies  >5 publications with CCNA1 and Lung Diseases
 Immune System Diseases Antibodies  >4 publications with CCNA1 and Immune System Diseases
 Nervous System Diseases Antibodies  >3 publications with CCNA1 and Nervous System Diseases
 Drug Toxicity Antibodies  >3 publications with CCNA1 and Drug Toxicity
 Ovarian Neoplasms Antibodies  >3 publications with CCNA1 and Ovarian Neoplasms
 Abnormalities, Drug-Induced Antibodies  >2 publications with CCNA1 and Abnormalities, Drug-Induced

Organs/Tissues associated with anti-CCNA1 antibody

 Organ/Tissue Name  Pubmed Publications
 Testis Antibodies  >21 publications with CCNA1 and Testis
 Lung Antibodies  >8 publications with CCNA1 and Lung
 Bone Marrow Antibodies  >6 publications with CCNA1 and Bone Marrow
 Brain Antibodies  >6 publications with CCNA1 and Brain
 Kidney Antibodies  >4 publications with CCNA1 and Kidney
 Vascular Antibodies  >4 publications with CCNA1 and Vascular
 Eye Antibodies  >3 publications with CCNA1 and Eye
 Cervix Antibodies  >3 publications with CCNA1 and Cervix
 Nerve Antibodies  >3 publications with CCNA1 and Nerve
 Heart Antibodies  >2 publications with CCNA1 and Heart
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