Human CBR4 Recombinant Protein – Cat# MBS1316891

Carbonyl Reductase Family Member 4 (CBR4) Human Recombinant Protein

Name: CBR4 Recombinant Protein; Human; MyBioSource
Brand: MyBioSource
SKU: MBS1316891
Price: 385 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1316891

The heterotetramer with HSD17B8 has NADH-dependent 3-ketoacyl-acyl carrier protein reductase activity, and thereby plays a role in mitochondrial fatty acid biosynthesis. Within the heterotetramer, HSD17B8 binds NADH; CBR4 binds NADPD. The homotetramer has… More details

$385 / 0.02 mg (E-Coli) +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Carbonyl reductase family member 4 (CBR4), Recombinant Protein

Full Product Name

Recombinant Human Carbonyl reductase family member 4 (CBR4)

Product Gene Name

CBR4 recombinant protein

Product Synonym Names

Carbonyl reductase family member 4; EC=1.-.-.-; 3-oxoacyl-[acyl-carrier-protein] reductase; EC=1.1.1.-; Quinone reductase CBR4

Sequence

MDKVCAVFGG SRGIGRAVAQ LMARKGYRLA VIARNLEGAK AAAGDLGGDH LAFSCDVAKE HDVQNTFEEL EKHLGRVNFL VNAAGINRDG LLVRTKTEDM VSQLHTNLLG SMLTCKAAMR TMIQQQGGSI VNVGSIVGLK GNSGQSVYSA SKGGLVGFSR ALAKEVARKK IRVNVVAPGF VHTDMTKDLK EEHLKKNIPL GRFGETIEVA HAVVFLLESP YITGHVLVVD GGLQLIL

Host

E Coli or Yeast or Baculovirus or Mammalian Cell

Form/Format

Lyophilized or liquid (Format to be determined during the manufacturing process)

Purity/Purification

Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)

Preparation and Storage

Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Molecular Weight

52.3 kDa

Sequence Positions

1-237aa; Full Length

Tag Information

This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.

Sterility

Sterile filter available upon request.

Endotoxin

Low endotoxin available upon request.

3D Structure

ModBase 3D Structure for Q8N4T8

Species

Homo sapiens (Human)

Product Categories/Family for CBR4 recombinant protein

Signal Transduction

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of CBR4 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CBR4 purchase

MBS1316891 is a recombinant protein targeting CBR4. Also known as Recombinant Human Carbonyl reductase family member 4 (CBR4). Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for CBR4. It may not necessarily be applicable to this product.

NCBI GI #

40254992

NCBI GeneID

84869

NCBI Accession #

NP_116172.2

UniProt Primary Accession #

Q8N4T8

UniProt Secondary Accession #

Q8WTW8; Q96K93

UniProt Related Accession #

Q8N4T8

GenBank Nucleotide #

NM_032783.4

NCBI Official Full Name

carbonyl reductase family member 4

NCBI Official Synonym Full Names

carbonyl reductase 4

NCBI Official Symbol

CBR4

NCBI Official Synonym Symbols

SDR45C1

UniProt Protein Name

Carbonyl reductase family member 4

UniProt Synonym Protein Names

3-oxoacyl-[acyl-carrier-protein] reductase (EC:1.1.1.-); Quinone reductase CBR4

Protein Family

Carbonyl reductase family

UniProt Gene Name

CBR4

UniProt Entry Name

CBR4_HUMAN

NCBI Protein Information

carbonyl reductase family member 4; carbonic reductase 4; quinone reductase CBR4; 3-oxoacyl-[acyl-carrier-protein] reductase; short chain dehydrogenase/reductase family 45C, member 1

UniProt Comments for CBR4

CBR4: The heteroteramer with HSD17B8 has NADH-dependent 3- ketoacyl-acyl carrier protein reductase activity. May play a role in biosynthesis of fatty acids in mitochondria. The homotetramer may act as NADPH-dependent quinone reductase. Has broad substrate specificity and reduces 9,10-phenanthrenequinone, 1,4-benzoquinone and various other o-quinones and p-quinones (in vitro). Belongs to the short-chain dehydrogenases/reductases (SDR) family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Oxidoreductase; EC 1.-.-.-; Mitochondrial; EC 1.1.1.-

Chromosomal Location of Human Ortholog: 4q32.3

Cellular Component: mitochondrial matrix

Molecular Function: protein binding; NAD(P)H dehydrogenase (quinone) activity; NADPH dehydrogenase (quinone) activity; quinone binding

Biological Process: fatty acid biosynthetic process; protein homotetramerization

Research Articles on CBR4

1. Observational study of gene-disease association. (HuGE Navigator)

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with CBR4 recombinant protein

Disease Name	Pubmed Publications
Fibrosis Antibodies	>1 publications with CBR4 and Fibrosis

Organs/Tissues associated with CBR4 recombinant protein

Organ/Tissue Name	Pubmed Publications
Liver Antibodies	>4 publications with CBR4 and Liver
Kidney Antibodies	>2 publications with CBR4 and Kidney
Muscle Antibodies	>1 publications with CBR4 and Muscle
Blood Antibodies	>1 publications with CBR4 and Blood
Vascular Antibodies	>1 publications with CBR4 and Vascular
Uterus Antibodies	>1 publications with CBR4 and Uterus
Prostate Antibodies	>1 publications with CBR4 and Prostate