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Nipped-B-Like Protein (NIPBL) Mouse Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1317315

This gene encodes the homolog of the Drosophila melanogaster Nipped-B gene product and fungal Scc2-type sister chromatid cohesion proteins. The Drosophila protein facilitates enhancer-promoter communication of remote enhancers and plays a role in… More details

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Testing Data View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
Nipped-B-like protein (Nipbl), Recombinant Protein
Full Product Name
Recombinant Mouse Nipped-B-like protein (Nipbl) , partial
Product Gene Name
Nipbl recombinant protein
Product Synonym Gene Name
Nipbl
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Molecular Weight
32,742 Da
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
3D Structure
ModBase 3D Structure for Q6KCD5
Species
Mouse
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of Nipbl recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Nipbl purchase

MBS1317315 is a recombinant protein targeting Nipbl. Also known as Recombinant Mouse Nipped-B-like protein (Nipbl) , partial. Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for Nipbl. It may not necessarily be applicable to this product.

NCBI GI #
49169845
NCBI GeneID
71175
NCBI Accession #
NP_081983.2
UniProt Primary Accession #
Q6KCD5
UniProt Secondary Accession #
Q6KC78; Q7TNS4; Q8BKV4; Q8CES9; Q9CUC6
UniProt Related Accession #
Q6KCD5
GenBank Nucleotide #
NM_027707.3
NCBI Official Full Name
nipped-B-like protein isoform a
NCBI Official Synonym Full Names
NIPBL cohesin loading factor
NCBI Official Symbol
Nipbl
NCBI Official Synonym Symbols
Idn3
UniProt Protein Name
Nipped-B-like protein
UniProt Synonym Protein Names
Delangin homolog; SCC2 homolog
Protein Family
Nipped-B-like protein
UniProt Gene Name
Nipbl
NCBI Protein Information
nipped-B-like protein

UniProt Comments for Nipbl

Plays an important role in the loading of the cohesin complex on to DNA (PubMed:29094699). Forms a heterodimeric complex (also known as cohesin loading complex) with MAU2/SCC4 which mediates the loading of the cohesin complex onto chromatin. Plays a role in cohesin loading at sites of DNA damage. Its recruitement to double-strand breaks (DSBs) sites occurs in a CBX3-, RNF8- and RNF168-dependent manner whereas its recruitement to UV irradiation-induced DNA damage sites occurs in a ATM-, ATR-, RNF8- and RNF168-dependent manner (). Along with ZNF609, promotes cortical neuron migration during brain development by regulating the transcription of crucial genes in this process. Preferentially binds promoters containing paused RNA polymerase II. Up-regulates the expression of SEMA3A, NRP1, PLXND1 and GABBR2 genes, among others (PubMed:28041881).
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Research Articles on Nipbl

1. Depletion of Zfp609 or Nipbl from cortical neural progenitors in vivo is detrimental to neuronal migration. Zfp609 and Nipbl overlap at genomic binding sites independently of cohesin and regulate genes that control cortical neuron migration.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with Nipbl recombinant protein

 Products by Pathway  Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle, Mitotic Pathway antibodies  Cell Cycle, Mitotic Pathway Diagram
 Cohesin Loading Onto Chromatin Pathway antibodies  Cohesin Loading Onto Chromatin Pathway Diagram
 M Phase Pathway antibodies  M Phase Pathway Diagram
 Mitotic Telophase/Cytokinesis Pathway antibodies  Mitotic Telophase/Cytokinesis Pathway Diagram

Diseases associated with Nipbl recombinant protein

 Disease Name  Pubmed Publications
 De Lange Syndrome Antibodies  >75 publications with Nipbl and De Lange Syndrome
 Nervous System Diseases Antibodies  >62 publications with Nipbl and Nervous System Diseases
 Craniofacial Abnormalities Antibodies  >8 publications with Nipbl and Craniofacial Abnormalities
 Microcephaly Antibodies  >5 publications with Nipbl and Microcephaly
 Heart Defects, Congenital Antibodies  >4 publications with Nipbl and Heart Defects, Congenital
 Neoplasms Antibodies  >3 publications with Nipbl and Neoplasms
 Cleft Palate Antibodies  >3 publications with Nipbl and Cleft Palate
 Nervous System Malformations Antibodies  >3 publications with Nipbl and Nervous System Malformations
 Bone Diseases, Developmental Antibodies  >2 publications with Nipbl and Bone Diseases, Developmental
 Eye Abnormalities Antibodies  >2 publications with Nipbl and Eye Abnormalities

Organs/Tissues associated with Nipbl recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Embryonic Tissue Antibodies  >3 publications with Nipbl and Embryonic Tissue
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