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Beta-Secretase 2 (BACE2) Rat Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1317482

Cerebral deposition of amyloid beta peptide is an early and critical feature of Alzheimer s disease and a frequent complication of Down syndrome. Amyloid beta peptide is generated by proteolytic cleavage of amyloid precursor protein by 2 proteases, one of… More details

$1675 / 0.5 mg (E-Coli) +2 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Beta-secretase 2 (Bace2), Recombinant Protein
Full Product Name
Recombinant Rat Beta-secretase 2 (Bace2), partial
Product Gene Name
Bace2 recombinant protein
Product Synonym Gene Name
Bace2
Sequence
VPVLAPAPFT LPLQVAGAAN HRASTVPGLG TPELPRADGL ALALEPARAT ANFLAMVDNL QGDSGRGYYL EMLIGTPPQK VRILVDTGSS NFAVAGAPHS YIDTYFDSES SSTYHSKGFE VTVKYTQGSW TGFVGEDLVT IPKGFNSSFL VNIATIFESE NFFLPGIKWN GILGLAYAAL AKPSSSLETF FDSLVAQAKI PDIFSMQMCG AGLPVAGSGT NGGSLVLGGI EPSLYKGDIW YTPIKEEWYY QIEILKLEIG GQSLNLDCRE YNADKAIVDS GTTLLRLPQK VFDAVVEAVA RTSLIPEFSD GFWTGAQLAC WTNSETPWAY FPKISIYLRD ENASRSFRIT ILPQLYIQPM MGAGFNYECY RFGISSSTNA LVIGATVMEG FYVVFDRAQR RVGFAVSPCA EIAGTTVSEI SGPFSTEDIA SNCVPAQALN EPILWIVSY
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Molecular Weight
55,858 Da
Sequence Positions
21-469
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
3D Structure
ModBase 3D Structure for Q6IE75
Species
Rat
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of Bace2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Bace2 purchase

MBS1317482 is a recombinant protein targeting Bace2. Also known as Recombinant Rat Beta-secretase 2 (Bace2), partial. Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for Bace2. It may not necessarily be applicable to this product.

NCBI GI #
50657390
NCBI GeneID
288227
NCBI Accession #
NP_001002802.1
UniProt Primary Accession #
Q6IE75
UniProt Secondary Accession #
B2GVB0
UniProt Related Accession #
Q6IE75
GenBank Nucleotide #
NM_001002802.1
NCBI Official Full Name
beta-secretase 2
NCBI Official Synonym Full Names
beta-site APP-cleaving enzyme 2
NCBI Official Symbol
Bace2
UniProt Protein Name
Beta-secretase 2
UniProt Synonym Protein Names
Beta-site amyloid precursor protein cleaving enzyme 2; Beta-site APP cleaving enzyme 2; Memapsin-1; Membrane-associated aspartic protease 1; Theta-secretase
Protein Family
Beta-secretase
UniProt Gene Name
Bace2
UniProt Synonym Gene Names
Beta-site APP cleaving enzyme 2
NCBI Protein Information
beta-secretase 2

UniProt Comments for Bace2

Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves APP, between residues 690 and 691, leading to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase. It has also been shown that it can cleave APP between residues 671 and 672 ().
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Research Articles on Bace2

1. found by global gene expression profiling that BACE2 was up-regulated in the rat pancreatic beta-cell line INS1E stably transfected with human IAPP gene

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with Bace2 recombinant protein

 Reference Product  PubMed Publications
 APP recombinant protein  >84 publications with Bace2 and APP

Pathways associated with Bace2 recombinant protein

 Products by Pathway  Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram

Diseases associated with Bace2 recombinant protein

 Disease Name  Pubmed Publications
 Necrosis Antibodies  >4 publications with Bace2 and Necrosis
 Learning Disorders Antibodies  >1 publications with Bace2 and Learning Disorders

Organs/Tissues associated with Bace2 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >79 publications with Bace2 and Brain
 Kidney Antibodies  >11 publications with Bace2 and Kidney
 Pancreas Antibodies  >8 publications with Bace2 and Pancreas
 Nerve Antibodies  >6 publications with Bace2 and Nerve
 Muscle Antibodies  >4 publications with Bace2 and Muscle
 Ovary Antibodies  >2 publications with Bace2 and Ovary
 Vascular Antibodies  >2 publications with Bace2 and Vascular
 Prostate Antibodies  >1 publications with Bace2 and Prostate
 Heart Antibodies  >1 publications with Bace2 and Heart
 Placenta Antibodies  >1 publications with Bace2 and Placenta
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