Human QKI Recombinant Protein – Cat# MBS1317791

Protein Quaking (QKI) Human Recombinant Protein

Name: QKI Recombinant Protein; Protein Quaking; Human; MyBioSource
Brand: MyBioSource
SKU: MBS1317791
Price: 455 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1317791

RNA-binding protein that plays a central role in myelinization. Binds to the 5'-NACUAAY-N(1,20)-UAAY-3' RNA core sequence. Regulates target mRNA stability. In addition, acts by regulating pre-mRNA splicing, mRNA export and protein translation. Required to… More details

$455 / 0.02 mg (E-Coli) +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Protein quaking (QKI), Recombinant Protein

Full Product Name

Recombinant Human Protein quaking (QKI)

Product Gene Name

QKI recombinant protein

Product Synonym Gene Name

QKI; HKQ

Product Synonym Names

Protein quaking; Hqk; HqkI

Sequence

MVGEMETKEK PKPTPDYLMQ LMNDKKLMSS LPNFCGIFNH LERLLDEEIS RVRKDMYNDT LNGSTEKRSA ELPDAVGPIV QLQEKLYVPV KEYPDFNFVG RILGPRGLTA KQLEAETGCK IMVRGKGSMR DKKKEEQNRG KPNWEHLNED LHVLITVEDA QNRAEIKLKR AVEEVKKLLV PAAEGEDSLK KMQLMELAIL NGTYRDANIK SPALAFSLAA TAQAAPRIIT GPAPVLPPAA LRTPTPAGPT IMPLIRQIQT AVMPNGTPHP TAAIVPPGPE AGLIYTPYEY PYTLAPATSI LEYPIEPSGV LGAVATKVRR HDMRVHPYQR IVTADRAATG N

Host

E Coli or Yeast or Baculovirus or Mammalian Cell

Form/Format

Lyophilized or liquid (Format to be determined during the manufacturing process)

Purity/Purification

Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)

Preparation and Storage

Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Molecular Weight

64.7 kDa

Sequence Positions

1-341aa; Full Length

Tag Information

This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.

Sterility

Sterile filter available upon request.

Endotoxin

Low endotoxin available upon request.

OMIM

609590

3D Structure

ModBase 3D Structure for Q96PU8

Species

Homo sapiens (Human)

Product Categories/Family for QKI recombinant protein

Neuroscience

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of QKI recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for QKI purchase

MBS1317791 is a recombinant protein targeting QKI. Also known as Recombinant Human Protein quaking (QKI). Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for QKI. It may not necessarily be applicable to this product.

NCBI GI #

45827706

NCBI GeneID

9444

NCBI Accession #

NP_006766.1

UniProt Primary Accession #

Q96PU8

UniProt Secondary Accession #

Q2I375; Q5MJQ1; Q969L9; Q96EJ3; Q96KA3; Q96PU6; Q96PU7; Q9P0X6; Q9P0X7; Q9P0X8; Q9P0X9

UniProt Related Accession #

Q96PU8

GenBank Nucleotide #

NM_006775.2

NCBI Official Full Name

protein quaking isoform 1

NCBI Official Synonym Full Names

QKI, KH domain containing, RNA binding

NCBI Official Symbol

QKI

NCBI Official Synonym Symbols

QK; Hqk; QK1; QK3; hqkI

UniProt Protein Name

Protein quaking

Protein Family

Protein quaking

UniProt Gene Name

QKI

UniProt Synonym Gene Names

HKQ; Hqk; HqkI

UniProt Entry Name

QKI_HUMAN

NCBI Protein Information

protein quaking; RNA binding protein HQK; quaking homolog, KH domain RNA binding; homolog of mouse quaking QKI (KH domain RNA binding protein)

NCBI Summary for QKI

The protein encoded by this gene is an RNA-binding protein that regulates pre-mRNA splicing, export of mRNAs from the nucleus, protein translation, and mRNA stability. The encoded protein is involved in myelinization and oligodendrocyte differentiation and may play a role in schizophrenia. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]

UniProt Comments for QKI

QKI: RNA-binding protein that plays a central role in myelinization. Binds to the 5'-NACUAAY-N(1,20)-UAAY-3' RNA core sequence. Acts by regulating pre-mRNA splicing, mRNA export, mRNA stability and protein translation. Required to protect and promote stability of mRNAs such as MBP and CDKN1B. Regulator of oligodendrocyte differentiation and maturation in the brain that may play a role in myelin and oligodendrocyte dysfunction in schizophrenia. Participates in mRNA transport by regulating the nuclear export of MBP mRNA. Also involved in regulation of mRNA splicing of MAG pre-mRNA. Acts as a translational repressor. 6 isoforms of the human protein are produced by alternative splicing.

Chromosomal Location of Human Ortholog: 6q26

Cellular Component: cytoplasm; nucleus

Molecular Function: mRNA binding; protein binding; SH3 domain binding

Biological Process: regulation of translation; myelination; muscle cell differentiation; mRNA transport; RNA splicing; long-chain fatty acid biosynthetic process; mRNA processing; vasculogenesis; spermatid development

Research Articles on QKI

1. the QKI-5 expression may be a novel, independent factor in the prognosis of prostate cancer patients.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with QKI recombinant protein

Reference Product	PubMed Publications
PRMT1 recombinant protein	>1 publications with QKI and PRMT1

Pathways associated with QKI recombinant protein

Products by Pathway	Pathway Diagram
Diurnally Regulated Genes With Circadian Orthologs Pathway antibodies	Diurnally Regulated Genes With Circadian Orthologs Pathway Diagram

Diseases associated with QKI recombinant protein

Disease Name	Pubmed Publications
Nervous System Diseases Antibodies	>16 publications with QKI and Nervous System Diseases
Neoplasms Antibodies	>15 publications with QKI and Neoplasms
Disease Models, Animal Antibodies	>3 publications with QKI and Disease Models, Animal
Inflammation Antibodies	>2 publications with QKI and Inflammation
Ovarian Neoplasms Antibodies	>2 publications with QKI and Ovarian Neoplasms
Endometrial Neoplasms Antibodies	>2 publications with QKI and Endometrial Neoplasms
Breast Neoplasms Antibodies	>2 publications with QKI and Breast Neoplasms
Ataxia Antibodies	>2 publications with QKI and Ataxia
Abnormalities, Multiple Antibodies	>2 publications with QKI and Abnormalities, Multiple
Cardiovascular Diseases Antibodies	>1 publications with QKI and Cardiovascular Diseases

Organs/Tissues associated with QKI recombinant protein

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>37 publications with QKI and Brain
Nerve Antibodies	>22 publications with QKI and Nerve
Embryonic Tissue Antibodies	>8 publications with QKI and Embryonic Tissue
Blood Antibodies	>7 publications with QKI and Blood
Heart Antibodies	>6 publications with QKI and Heart
Vascular Antibodies	>6 publications with QKI and Vascular
Muscle Antibodies	>4 publications with QKI and Muscle
Testis Antibodies	>2 publications with QKI and Testis
Kidney Antibodies	>2 publications with QKI and Kidney
Stomach Antibodies	>1 publications with QKI and Stomach