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CD166 Antigen (ALCAM) Human Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1317857

Cell adhesion molecule that mediates both heterotypic cell-cell contacts via its interaction with CD6, as well as homotypic cell-cell contacts. Promotes T-cell activation and proliferation via its interactions with CD6. Contributes to the formation and… More details

$315 / 0.02 mg (E-Coli) +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
CD166 antigen (ALCAM), Recombinant Protein
Full Product Name
Recombinant Human CD166 antigen (ALCAM)
Product Gene Name
ALCAM recombinant protein
Product Synonym Gene Name
ALCAM; MEMD
Product Synonym Names
CD166 antigen; Activated leukocyte cell adhesion molecule; CD_antigen=; CD166
Sequence
WYTVNSAYGD TIIIPCRLDV PQNLMFGKWK YEKPDGSPVF IAFRSSTKKS VQYDDVPEYK DRLNLSENYT LSISNARISD EKRFVCMLVT EDNVFEAPTI VKVFKQPSKP EIVSKALFLE TEQLKKLGDC ISEDSYPDGN ITWYRNGKVL HPLEGAVVII FKKEMDPVTQ LYTMTSTLEY KTTKADIQMP FTCSVTYYGP SGQKTIHSEQ AVFDIYYPTE QVTIQVLPPK NAIKEGDNIT LKCLGNGNPP PEEFLFYLPG QPEGIRSSNT YTLTDVRRNA TGDYKCSLID KKSMIASTAI TVHYLDLSLN PSGEVTRQIG DALPVSCTIS ASRNATVVWM KDNIRLRSSP SFSSLHYQDA GNYVCETALQ EVEGLKKRES LTLIVEGKPQ IKMTKKTDPS GLSKTIICHV EGFPKPAIQW TITGSGSVIN QTEESPYING RYYSKIIISP EENVTLTCTA ENQLERTVNS LNVSAISIPE HDEADEISD
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Molecular Weight
70.8 kDa
Sequence Positions
28-516aa; Partial
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
OMIM
601662
3D Structure
ModBase 3D Structure for Q13740
Species
Homo sapiens (Human)
Production Note
Special Offer: The E Coli host-expressed protein is manufactured from a stock plasmid containing the protein gene. E Colihost-expressed protein is stocked in different unit sizes ranging from as small as 10 ug to as large as 1 mg. Bulk inventory is also available. The E Coli host-expressed protein has been ordered over and over again by researchers and has stood the test of time as both a robust protein and important target for the research community. It is part of our new program to make our most popular protein targets and corresponding hosts available in expanded unit sizes and with a quick processing time. Select E Coli host-expressed protein for the fastest delivery among all hosts. Please contact our technical support team or email to support@mybiosource.com for more details.

Product Categories/Family for ALCAM recombinant protein

Immunology
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

SDS-Page of ALCAM recombinant protein

Human ALCAM Recombinant Protein – Cat# MBS1317857

Other Notes

Small volumes of ALCAM recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ALCAM purchase

MBS1317857 is a recombinant protein targeting ALCAM. Also known as Recombinant Human CD166 antigen (ALCAM). Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for ALCAM. It may not necessarily be applicable to this product.

NCBI GI #
343168770
NCBI GeneID
214
NCBI Accession #
NP_001230209.1
UniProt Primary Accession #
Q13740
UniProt Secondary Accession #
O60892; Q1HGM8; Q1HGM9; Q6PEY4; Q6ZS95; B2RNS3; B4DTU0
UniProt Related Accession #
Q13740
GenBank Nucleotide #
NM_001243280.1
NCBI Official Full Name
CD166 antigen isoform 2
NCBI Official Synonym Full Names
activated leukocyte cell adhesion molecule
NCBI Official Symbol
ALCAM
NCBI Official Synonym Symbols
MEMD; CD166
UniProt Protein Name
CD166 antigen
UniProt Synonym Protein Names
Activated leukocyte cell adhesion molecule; CD_antigen: CD166
Protein Family
CD166 antigen
UniProt Gene Name
ALCAM
UniProt Synonym Gene Names
MEMD
UniProt Entry Name
CD166_HUMAN
NCBI Protein Information
CD166 antigen

NCBI Summary for ALCAM

This gene encodes activated leukocyte cell adhesion molecule (ALCAM), also known as CD166 (cluster of differentiation 166), which is a member of a subfamily of immunoglobulin receptors with five immunoglobulin-like domains (VVC2C2C2) in the extracellular domain. This protein binds to T-cell differentiation antigene CD6, and is implicated in the processes of cell adhesion and migration. Multiple alternatively spliced transcript variants encoding different isoforms have been found. [provided by RefSeq, Aug 2011]
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UniProt Comments for ALCAM

ALCAM: Cell adhesion molecule that binds to CD6. Involved in neurite extension by neurons via heterophilic and homophilic interactions. May play a role in the binding of T- and B-cells to activated leukocytes, as well as in interactions between cells of the nervous system. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Cell adhesion

Chromosomal Location of Human Ortholog: 3q13.1

Cellular Component: focal adhesion; cell soma; axon; integral to membrane; external side of plasma membrane

Molecular Function: protein binding; receptor binding

Biological Process: axon guidance; motor axon guidance; cell adhesion; signal transduction
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Research Articles on ALCAM

1. By directly targeting the Rho GDP dissociation inhibitor alpha (RhoGDI1) and activated leukocyte cell adhesion molecule (ALCAM).

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with ALCAM recombinant protein

 Reference Product  PubMed Publications
 CD6 recombinant protein  >57 publications with ALCAM and CD6
 GRASP recombinant protein  >32 publications with ALCAM and GRASP
 L1CAM recombinant protein  >5 publications with ALCAM and L1CAM
 EGFR recombinant protein  >2 publications with ALCAM and EGFR
 CD5L recombinant protein  >1 publications with ALCAM and CD5L
 RELA recombinant protein  >1 publications with ALCAM and RELA

Pathways associated with ALCAM recombinant protein

 Products by Pathway  Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 L1CAM Interactions Pathway antibodies  L1CAM Interactions Pathway Diagram

Diseases associated with ALCAM recombinant protein

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >131 publications with ALCAM and Neoplasms
 Carcinoma Antibodies  >44 publications with ALCAM and Carcinoma
 Skin Diseases Antibodies  >35 publications with ALCAM and Skin Diseases
 Breast Neoplasms Antibodies  >26 publications with ALCAM and Breast Neoplasms
 Adenocarcinoma Antibodies  >19 publications with ALCAM and Adenocarcinoma
 Immune System Diseases Antibodies  >17 publications with ALCAM and Immune System Diseases
 Inflammation Antibodies  >16 publications with ALCAM and Inflammation
 Brain Diseases Antibodies  >14 publications with ALCAM and Brain Diseases
 Necrosis Antibodies  >13 publications with ALCAM and Necrosis
 Prostatic Neoplasms Antibodies  >12 publications with ALCAM and Prostatic Neoplasms

Organs/Tissues associated with ALCAM recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >117 publications with ALCAM and Blood
 Nerve Antibodies  >61 publications with ALCAM and Nerve
 Bone Antibodies  >58 publications with ALCAM and Bone
 Embryonic Tissue Antibodies  >54 publications with ALCAM and Embryonic Tissue
 Brain Antibodies  >52 publications with ALCAM and Brain
 Bone Marrow Antibodies  >43 publications with ALCAM and Bone Marrow
 Vascular Antibodies  >39 publications with ALCAM and Vascular
 Lung Antibodies  >29 publications with ALCAM and Lung
 Muscle Antibodies  >25 publications with ALCAM and Muscle
 Eye Antibodies  >22 publications with ALCAM and Eye
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