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Matrix Metalloproteinase-17 (MMP17) Mouse Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1319327

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as… More details

$1195 / 0.02 mg (E-Coli) +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Matrix metalloproteinase-17 (Mmp17), Recombinant Protein
Full Product Name
Recombinant Mouse Matrix metalloproteinase-17 (Mmp17)
Product Gene Name
Mmp17 recombinant protein
Product Synonym Gene Name
Mmp17
Sequence
QTPPPTKWSK RNLSWRVRTF PRDSPLGRDT VRALMYYALK VWSDITPLNF HEVAGNAADI QIDFSKADHN DGYPFDGPGG TVAHAFFPGD HHTAGDTHFD DDEPWTFRSS DAHGMDLFAV AVHEFGHAIG LSHVAAPSSI MQPYYQGPVG DPLRYGLPYE DRVRVWQLYG VRESVSPTAQ LDTPEPEEPP LLPEPPNNRS STPPQKDVPH RCTAHFDAVA QIRGEAFFFK GKYFWRLTRD RHLVSLQPAQ MHRFWRGLPL HLDSVDAVYE RTSDHKIVFF KGDRYWVFKD NNVEEGYPRP VSDFSLPPGG IDAVFSWAHN DRTYFFKDQL YWRYDDHTRR MDPGYPAQGP LWRGVPSMLD DAMRWSDGAS YFFRGQEYWK VLDGELEAAP GYPQSTARDW LVCGEPLADA EDVGPGPQGR SGAQDGLAVC SCTS
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Molecular Weight
64,333 Da
Sequence Positions
125-558, full length protein
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
3D Structure
ModBase 3D Structure for Q9R0S3
Species
Mouse
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of Mmp17 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Mmp17 purchase

MBS1319327 is a recombinant protein targeting Mmp17. Also known as Recombinant Mouse Matrix metalloproteinase-17 (Mmp17). Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for Mmp17. It may not necessarily be applicable to this product.

NCBI GI #
31543257
NCBI GeneID
23948
NCBI Accession #
NP_035976.3
UniProt Primary Accession #
Q9R0S3
UniProt Secondary Accession #
Q80UM9
UniProt Related Accession #
Q9R0S3
GenBank Nucleotide #
NM_011846.5
NCBI Official Full Name
matrix metalloproteinase-17 preproprotein
NCBI Official Synonym Full Names
matrix metallopeptidase 17
NCBI Official Symbol
Mmp17
NCBI Official Synonym Symbols
MT4MMP; MTMMP4; MT4-MMP
UniProt Protein Name
Matrix metalloproteinase-17
UniProt Synonym Protein Names
Membrane-type matrix metalloproteinase 4; MT-MMP 4; MTMMP4; Membrane-type-4 matrix metalloproteinase; MT4-MMP; MT4MMP
Protein Family
Matrix metalloproteinase
UniProt Gene Name
Mmp17
UniProt Synonym Gene Names
Mt4mmp; MMP-17; MT-MMP 4; MTMMP4; MT4-MMP; MT4MMP
NCBI Protein Information
matrix metalloproteinase-17

NCBI Summary for Mmp17

This gene encodes a member of the matrix metalloproteinase family of extracellular matrix-degrading enzymes that are involved in tissue remodeling, wound repair, progression of atherosclerosis and tumor invasion. The encoded preproprotein undergoes proteolytic processing to generate a mature, zinc-dependent endopeptidase enzyme. Mice lacking the encoded protein exhibit dysfunctional vascular smooth muscle cells and altered extracellular matrix in the vessel wall leading to an increased susceptibility to angiotensin-II-induced thoracic aortic aneurysm. [provided by RefSeq, Feb 2016]
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UniProt Comments for Mmp17

Endopeptidase that degrades various components of the extracellular matrix, such as fibrin. May be involved in the activation of membrane-bound precursors of growth factors or inflammatory mediators, such as tumor necrosis factor-alpha. May also be involved in tumoral process. Not obvious if able to proteolytically activate progelatinase A. Does not hydrolyze collagen types I, II, III, IV and V, gelatin, fibronectin, laminin, decorin nor alpha1-antitrypsin.
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Research Articles on Mmp17

1. while Adam17-deficiency suppresses Ang II-induced SMC remodeling in vitro, in vivo Adam17-deficiency provides only a transient protective effect against Ang II-mediated hypertension and end-organ damage.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with Mmp17 recombinant protein

 Reference Product  PubMed Publications
 Adamts4 recombinant protein  >4 publications with Mmp17 and Adamts4
 Mmp2 recombinant protein  >3 publications with Mmp17 and Mmp2
 Sdc1 recombinant protein  >2 publications with Mmp17 and Sdc1
 Furin recombinant protein  >2 publications with Mmp17 and Furin
 Timp1 recombinant protein  >2 publications with Mmp17 and Timp1
 Timp2 recombinant protein  >1 publications with Mmp17 and Timp2

Pathways associated with Mmp17 recombinant protein

 Products by Pathway  Pathway Diagram
 Matrix Metalloproteinases Pathway antibodies  Matrix Metalloproteinases Pathway Diagram

Diseases associated with Mmp17 recombinant protein

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >9 publications with Mmp17 and Neoplasms
 Carcinoma Antibodies  >5 publications with Mmp17 and Carcinoma
 Necrosis Antibodies  >4 publications with Mmp17 and Necrosis
 Skin Diseases Antibodies  >3 publications with Mmp17 and Skin Diseases
 Breast Neoplasms Antibodies  >3 publications with Mmp17 and Breast Neoplasms
 Gastrointestinal Diseases Antibodies  >2 publications with Mmp17 and Gastrointestinal Diseases
 Bone Marrow Diseases Antibodies  >1 publications with Mmp17 and Bone Marrow Diseases
 Nervous System Diseases Antibodies  >1 publications with Mmp17 and Nervous System Diseases
 Anemia Antibodies  >1 publications with Mmp17 and Anemia
 Neoplasm Metastasis Antibodies  >1 publications with Mmp17 and Neoplasm Metastasis

Organs/Tissues associated with Mmp17 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >4 publications with Mmp17 and Brain
 Bone Antibodies  >2 publications with Mmp17 and Bone
 Eye Antibodies  >2 publications with Mmp17 and Eye
 Intestine Antibodies  >1 publications with Mmp17 and Intestine
 Embryonic Tissue Antibodies  >1 publications with Mmp17 and Embryonic Tissue
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