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Nuclear Pore Complex Protein Nup50 (NUP50) Mouse Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1323221

The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins are the main components of the nuclear pore complex in… More details

$1240 / 0.02 mg (E-Coli) +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Nuclear pore complex protein Nup50 (Nup50), Recombinant Protein
Full Product Name
Recombinant Mouse Nuclear pore complex protein Nup50 (Nup50)
Product Gene Name
Nup50 recombinant protein
Product Synonym Gene Name
Nup50
Sequence
MAKRVAEKEL TDRNWDEEDE VEEMGTFSVA SEEVMKNRAV KKAKRRNVGF ESDSGGAFKG FKGLVVPSGG GGFSGFGGSG GKPLEGLTNG NSTDNATPFS NVKTAAEPKA AFGSFAVNGP TTLVDKKISS PKCNNSNQPP SSGPASSTAC PGNAYHKQLA GLNCSVRDWI VKHVNTNPLC DLTPIFKDYE RYLATIEKQL ENGGGSSSES QTDRATAGME PPSLFGSTKL QQESPFSFHG NKAEDTSEKV EFTAEKKSDA AQGATSASFS FGKKIESSAL GSLSSGSLTG FSFSAGSSSL FGKDAAQSKA ASSLFSAKAS ESPAGGGSSE CRDGEEEEND EPPKVVVTEV KEEDAFYSKK CKLFYKKDNE FKEKGVGTLH LKPTATQKTQ LLVRADTNLG NILLNVLIAP NMPCTRTGKN NVLIVCVPNP PLDEKQPTLP ATMLIRVKTS EDADELHKIL LEKKDA
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Molecular Weight
49,485 Da
Sequence Positions
1-466, full length protein
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
3D Structure
ModBase 3D Structure for Q9JIH2
Species
Mouse
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of Nup50 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Nup50 purchase

MBS1323221 is a recombinant protein targeting Nup50. Also known as Recombinant Mouse Nuclear pore complex protein Nup50 (Nup50). Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for Nup50. It may not necessarily be applicable to this product.

NCBI GI #
38016154
NCBI GeneID
18141
NCBI Accession #
NP_057923.2
UniProt Primary Accession #
Q9JIH2
UniProt Secondary Accession #
Q3TG43; Q3TN17; Q6P1F4; Q6PAL4; Q8C2Y6; Q9CU02; Q9JK85
UniProt Related Accession #
Q9JIH2
GenBank Nucleotide #
NM_016714.2
NCBI Official Full Name
nuclear pore complex protein Nup50
NCBI Official Synonym Full Names
nucleoporin 50
NCBI Official Symbol
Nup50
NCBI Official Synonym Symbols
Npap60; AI413123; 1700030K07Rik
UniProt Protein Name
Nuclear pore complex protein Nup50
UniProt Synonym Protein Names
50 kDa nucleoporin; Nuclear pore-associated protein 60 kDa-like; Nucleoporin Nup50
Protein Family
Nuclear pore complex protein
UniProt Gene Name
Nup50
UniProt Synonym Gene Names
Npap60
NCBI Protein Information
nuclear pore complex protein Nup50

UniProt Comments for Nup50

Component of the nuclear pore complex that has a direct role in nuclear protein import (PubMed:10811608). Actively displaces NLSs from importin-alpha, and facilitates disassembly of the importin-alpha:beta-cargo complex and importin recycling (PubMed:16222336). Interacts with regulatory proteins of cell cycle progression including CDKN1B (PubMed:10891500, PubMed:10811608). This interaction is required for correct intracellular transport and degradation of CDKN1B (PubMed:10811608).
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Research Articles on Nup50

1. results suggest that nucleoporin 50 plays an essential role in the survival of primordial germ cells during embryonic development

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with Nup50 recombinant protein

 Products by Pathway  Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 Glucose Transport Pathway antibodies  Glucose Transport Pathway Diagram
 Hexose Transport Pathway antibodies  Hexose Transport Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Carbohydrates Pathway antibodies  Metabolism Of Carbohydrates Pathway Diagram
 Metabolism Of Non-coding RNA Pathway antibodies  Metabolism Of Non-coding RNA Pathway Diagram
 Nuclear Pore Complex Pathway antibodies  Nuclear Pore Complex Pathway Diagram
 Processing Of Capped Intron-Containing Pre-mRNA Pathway antibodies  Processing Of Capped Intron-Containing Pre-mRNA Pathway Diagram
 RNA Transport Pathway antibodies  RNA Transport Pathway Diagram
 RNA Transport Pathway antibodies  RNA Transport Pathway Diagram

Diseases associated with Nup50 recombinant protein

 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >1 publications with Nup50 and Nervous System Diseases
 Liver Failure, Acute Antibodies  >1 publications with Nup50 and Liver Failure, Acute
 Neural Tube Defects Antibodies  >1 publications with Nup50 and Neural Tube Defects
 Liver Diseases Antibodies  >1 publications with Nup50 and Liver Diseases
 Fetal Death Antibodies  >1 publications with Nup50 and Fetal Death

Organs/Tissues associated with Nup50 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Testis Antibodies  >1 publications with Nup50 and Testis
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