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Intraflagellar Transport Protein 74 Homolog (IFT74) Human Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1324565

MBS1324565 is a recombinant protein targeting IFT74. Also known as Recombinant Human Intraflagellar transport protein 74 homolog (IFT74). Host: E Coli or Yeast or Baculovirus or Mammalian Cell. More details

$1395 / 0.02 mg (E-Coli) +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Intraflagellar transport protein 74 homolog (IFT74), Recombinant Protein
Full Product Name
Recombinant Human Intraflagellar transport protein 74 homolog (IFT74)
Product Gene Name
IFT74 recombinant protein
Product Synonym Gene Name
IFT74
Sequence
MASNHKSSAA RPVSRGGVGL TGRPPSGIRP LSGNIRVATA MPPGTARPGS RGCPIGTGGV LSSQIKVAHR PVTQQGLTGM KTGTKGPQRQ ILDKSYYLGL LRSKISELTT EVNKLQKGIE MYNQENSVYL SYEKRAETLA VEIKELQGQL ADYNMLVDKL NTNTEMEEVM NDYNMLKAQN DRETQSLDVI FTERQAKEKQ IRSVEEEIEQ EKQATDDIIK NMSFENQVKY LEMKTTNEKL LQELDTLQQQ LDSQNMKKES LEAEIAHSQV KQEAVLLHEK LYELESHRDQ MIAEDKSIGS PMEEREKLLK QIKDDNQEIA SMERQLTDTK EKINQFIEEI RQLDMDLEEH QGEMNQKYKE LKKREEHMDT FIETFEETKN QELKRKAQIE ANIVALLEHC SRNINRIEQI SSITNQELKM MQDDLNFKST EVQKSQSTAQ NLTSDIQRLQ LDLQKMELLE SKMTEEQHSL KSKIKQMTTD LEIYNDLPAL KSSGEEKIKK LHQERMILST HRNAFKKIME KQNIEYEALK TQLQENETHS QLTNLERKWQ HLEQNNFAMK EFIATKSQES DYQPIKKNVT KQIAEYNKTI VDALHSTSGN
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Molecular Weight
42,332 Da
Sequence Positions
1-600, Full length protein
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
OMIM
608040
3D Structure
ModBase 3D Structure for Q96LB3
Species
Human
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of IFT74 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for IFT74. It may not necessarily be applicable to this product.

NCBI GI #
151105223
NCBI GeneID
80173
NCBI Accession #
NP_001092692.1
UniProt Primary Accession #
Q96LB3
UniProt Secondary Accession #
Q3B789; Q5VY34; Q6PGQ8; Q9H643; Q9H8G7
UniProt Related Accession #
Q96LB3
GenBank Nucleotide #
NM_001099222.2
NCBI Official Full Name
intraflagellar transport protein 74 homolog isoform a
NCBI Official Synonym Full Names
intraflagellar transport 74
NCBI Official Symbol
IFT74
NCBI Official Synonym Symbols
CMG1; BBS20; CCDC2; CMG-1
UniProt Protein Name
Intraflagellar transport protein 74 homolog
UniProt Synonym Protein Names
Capillary morphogenesis gene 1 protein; CMG-1; Coiled-coil domain-containing protein 2
Protein Family
Intraflagellar transport protein
UniProt Gene Name
IFT74
UniProt Synonym Gene Names
CCDC2; CMG1; CMG-1
NCBI Protein Information
intraflagellar transport protein 74 homolog

NCBI Summary for IFT74

This gene encodes a core intraflagellar transport (IFT) protein which belongs to a multi-protein complex involved in the transport of ciliary proteins along axonemal microtubules. IFT proteins are found at the base of the cilium as well as inside the cilium, where they assemble into long arrays between the ciliary base and tip. This protein, together with intraflagellar transport protein 81, binds and transports tubulin within cilia and is required for ciliogenesis. Naturally occurring mutations in this gene are associated with amyotrophic lateral sclerosis--frontotemporal dementia and Bardet-Biedl Syndrome. [provided by RefSeq, Mar 2017]
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UniProt Comments for IFT74

Component of the intraflagellar transport (IFT) complex B: together with IFT81, forms a tubulin-binding module that specifically mediates transport of tubulin within the cilium. Binds beta-tubulin via its basic region. Required for ciliogenesis.

Research Articles on IFT74

1. this study found that the two core intraflagellar transport proteins IFT74 and IFT81 form a tubulin-binding module and mapped the interaction to a calponin homology domain of IFT81 and a highly basic domain in IFT74.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with IFT74 recombinant protein

 Reference Product  PubMed Publications
 IFT81 recombinant protein  >4 publications with IFT74 and IFT81
 IFT172 recombinant protein  >2 publications with IFT74 and IFT172
 IFT88 recombinant protein  >2 publications with IFT74 and IFT88
 IFT27 recombinant protein  >2 publications with IFT74 and IFT27
 IFT52 recombinant protein  >2 publications with IFT74 and IFT52
 IFT20 recombinant protein  >1 publications with IFT74 and IFT20
 IFT80 recombinant protein  >1 publications with IFT74 and IFT80

Pathways associated with IFT74 recombinant protein

 Products by Pathway  Pathway Diagram
 Assembly Of The Primary Cilium Pathway antibodies  Assembly Of The Primary Cilium Pathway Diagram
 Intraflagellar Transport Pathway antibodies  Intraflagellar Transport Pathway Diagram
 Organelle Biogenesis And Maintenance Pathway antibodies  Organelle Biogenesis And Maintenance Pathway Diagram

Diseases associated with IFT74 recombinant protein

 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >4 publications with IFT74 and Nervous System Diseases
 Kidney Diseases Antibodies  >1 publications with IFT74 and Kidney Diseases

Organs/Tissues associated with IFT74 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Kidney Antibodies  >2 publications with IFT74 and Kidney
 Muscle Antibodies  >1 publications with IFT74 and Muscle
 Eye Antibodies  >1 publications with IFT74 and Eye
 Vascular Antibodies  >1 publications with IFT74 and Vascular
 Embryonic Tissue Antibodies  >1 publications with IFT74 and Embryonic Tissue
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