Rabbit Anti-RFWD3 Antibody – Cat# MBS001325

RFWD3 Antibody – Rabbit

Name: RFWD3 Antibody; Rabbit; Human-Reactive; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS001325
Price: 595 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS001325

MBS001325 is an antibody targeting RFWD3. Also known as Rabbit RFWD3 Antibody. Reactive in Human. Host: Rabbit. More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

RFWD3, Antibody

Full Product Name

Rabbit RFWD3 Antibody

Product Gene Name

anti-RFWD3 antibody

Host

Rabbit

Species Reactivity

Human

Form/Format

Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol

Concentration

1 mg/ml (lot specific)

Molecular Weight

85,094 Da

Chromosome Location

Chromosome: 16; NC_000016.9 (74655297..74700779, complement). Location: 16q23.1

OMIM

614151

3D Structure

ModBase 3D Structure for Q6PCD5

Applications Tested/Suitable for anti-RFWD3 antibody

ELISA (EIA), Western Blot (WB)

Other Notes

Small volumes of anti-RFWD3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for RFWD3. It may not necessarily be applicable to this product.

NCBI GI #

71143112

NCBI GeneID

55159

NCBI Accession #

NP_060594.3

UniProt Primary Accession #

Q6PCD5

UniProt Secondary Accession #

Q5XKR3; Q9H9Q3; Q9NVT4; A8K585; B2RE35; D3DUJ8

UniProt Related Accession #

Q6PCD5

GenBank Nucleotide #

NM_018124.3

NCBI Official Full Name

E3 ubiquitin-protein ligase RFWD3

NCBI Official Synonym Full Names

ring finger and WD repeat domain 3

NCBI Official Symbol

RFWD3

NCBI Official Synonym Symbols

RNF201

UniProt Protein Name

E3 ubiquitin-protein ligase RFWD3

UniProt Synonym Protein Names

RING finger and WD repeat domain-containing protein 3; RING finger protein 201

Protein Family

E3 ubiquitin-protein ligase

UniProt Gene Name

RFWD3

UniProt Synonym Gene Names

RNF201

UniProt Entry Name

RFWD3_HUMAN

NCBI Protein Information

E3 ubiquitin-protein ligase RFWD3; RING finger protein 201; RING finger and WD repeat domain-containing protein 3

UniProt Comments for RFWD3

RFWD3: E3 ubiquitin-protein ligase that mediates the ubiquitination of p53/TP53 in the late response to DNA damage, and acts as a positive regulator of p53/TP53 stability, thereby regulating the G1/S DNA damage checkpoint. May act by catalyzing the formation of short polyubiquitin chains on p53/TP53 that are not targeted to the proteasome. In response to ionizing radiation, interacts with MDM2 and enhances p53/TP53 ubiquitination, possibly by restricting MDM2 from extending polyubiquitin chains on ubiquitinated p53/TP53. Plays a role in RPA-mediated DNA damage signaling and repair.

Protein type: EC 6.3.2.-; EC 6.3.2.19; Ubiquitin ligase; Ubiquitin conjugating system

Chromosomal Location of Human Ortholog: 16q23.1

Cellular Component: PML body; cytoplasm; nucleus

Molecular Function: protein binding; zinc ion binding; p53 binding; ubiquitin-protein ligase activity; ligase activity

Biological Process: G1 DNA damage checkpoint; protein ubiquitination; response to ionizing radiation; DNA repair

Research Articles on RFWD3

1. RFWD3 and RPA2 functionally interact and participate in replication checkpoint control

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with anti-RFWD3 antibody

Disease Name	Pubmed Publications
Neoplasms Antibodies	>1 publications with RFWD3 and Neoplasms
Testicular Germ Cell Tumor Antibodies	>1 publications with RFWD3 and Testicular Germ Cell Tumor