• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

Growth Factor Receptor-Bound Protein 14 (GRB14) Mouse Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1326907

The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with insulin… More details

$1345 / 0.02 mg (E-Coli) +1 FREE 8GB USB
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Growth factor receptor-bound protein 14 (Grb14), Recombinant Protein
Full Product Name
Recombinant Mouse Growth factor receptor-bound protein 14 (Grb14)
Product Gene Name
Grb14 recombinant protein
Product Synonym Gene Name
Grb14
Sequence
TTSLQDGQSA AGRAGAQDSP LAVQVCRVAQ GKGDAQDPAQ VPGLHALSPA SDATLRGAID RRKMKDLDVL EKPPIPNPFP ELCCSPLTSV LSAGLFPRAN SRKKQVIKVY SEDETSRALE VPSDITARDV CQLLILKNHY VDDNSWTLFE HLSHIGLERT VEDHELPTEV LSHWGVEEDN KLYLRKNYAK YEFFKNPMYF FPEHMVSFAA EMNGDRSPTQ ILQVFLSSST YPEIHGFLHA KEQGKKSWKK AYFFLRRSGL YFSTKGTSKE PRHLQLFSEF STSHVYMSLA GKKKHGAPTP YGFCLKPNKA GGPRDLKMLC AEEEQSRTCW VTAIRLLKDG MQLYQNYMHP YQGRSACNSQ SMSPMRSVSE NSLVAMDFSG EKSRVIDNPT EALSVAVEEG LAWRKKGCLR LGNHGSPSAP SQSSAVNMAL HRSQPWFHHR ISRDEAQRLI IRQGPVDGVF LVRDSQSNPR TFVLSMSHGQ KIKHYQIIPV EDDGELFHTL DDGHTKFTDL IQLVEFYQLN RGVLPCKLKH YCARMAV
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Molecular Weight
60,573 Da
Sequence Positions
2-538aa; Full Length of Mature Protein
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
3D Structure
ModBase 3D Structure for Q9JLM9
Species
Mouse
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of Grb14 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Grb14 purchase

MBS1326907 is a recombinant protein targeting Grb14. Also known as Recombinant Mouse Growth factor receptor-bound protein 14 (Grb14). Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for Grb14. It may not necessarily be applicable to this product.

NCBI GI #
7710032
NCBI GeneID
50915
NCBI Accession #
NP_057928.1
UniProt Primary Accession #
Q9JLM9
UniProt Secondary Accession #
Q3UI77; Q8VDI2; Q9CR03
UniProt Related Accession #
Q9JLM9
GenBank Nucleotide #
NM_016719.1
NCBI Official Full Name
growth factor receptor-bound protein 14
NCBI Official Synonym Full Names
growth factor receptor bound protein 14
NCBI Official Symbol
Grb14
NCBI Official Synonym Symbols
AI505286
UniProt Protein Name
Growth factor receptor-bound protein 14
UniProt Synonym Protein Names
GRB14 adapter protein
Protein Family
Growth factor receptor-bound protein
UniProt Gene Name
Grb14
NCBI Protein Information
growth factor receptor-bound protein 14

UniProt Comments for Grb14

Adapter protein which modulates coupling of cell surface receptor kinases with specific signaling pathways. Binds to, and suppresses signals from, the activated insulin receptor (INSR). Potent inhibitor of insulin-stimulated MAPK3 phosphorylation. Plays a critical role regulating PDPK1 membrane translocation in response to insulin stimulation and serves as an adapter protein to recruit PDPK1 to activated insulin receptor, thus promoting PKB/AKT1 phosphorylation and transduction of the insulin signal ().
Show more

Research Articles on Grb14

1. Study reveals that Grb14 acts as a new signaling node that regulates lipogenesis and modulates insulin sensitivity in the liver by acting at a crossroad between the insulin receptor and the p62-Nrf2-LXR signaling pathways.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with Grb14 recombinant protein

 Products by Pathway  Pathway Diagram
 Cell Surface Interactions At The Vascular Wall Pathway antibodies  Cell Surface Interactions At The Vascular Wall Pathway Diagram
 EGFR1 Signaling Pathway antibodies  EGFR1 Signaling Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 Insulin Signaling Pathway antibodies  Insulin Signaling Pathway Diagram
 Tie2 Signaling Pathway antibodies  Tie2 Signaling Pathway Diagram

Diseases associated with Grb14 recombinant protein

 Disease Name  Pubmed Publications
 Disease Models, Animal Antibodies  >4 publications with Grb14 and Disease Models, Animal
 Breast Neoplasms Antibodies  >4 publications with Grb14 and Breast Neoplasms
 Neoplasms Antibodies  >4 publications with Grb14 and Neoplasms
 Diabetes Mellitus, Type 2 Antibodies  >2 publications with Grb14 and Diabetes Mellitus, Type 2
 Adenocarcinoma Antibodies  >1 publications with Grb14 and Adenocarcinoma
 Myocardial Infarction Antibodies  >1 publications with Grb14 and Myocardial Infarction
 Weight Loss Antibodies  >1 publications with Grb14 and Weight Loss
 Cardiovascular Diseases Antibodies  >1 publications with Grb14 and Cardiovascular Diseases
 Hypertension Antibodies  >1 publications with Grb14 and Hypertension
 Necrosis Antibodies  >1 publications with Grb14 and Necrosis

Organs/Tissues associated with Grb14 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >13 publications with Grb14 and Muscle
 Liver Antibodies  >13 publications with Grb14 and Liver
 Eye Antibodies  >7 publications with Grb14 and Eye
 Ovary Antibodies  >5 publications with Grb14 and Ovary
 Kidney Antibodies  >5 publications with Grb14 and Kidney
 Heart Antibodies  >5 publications with Grb14 and Heart
 Embryonic Tissue Antibodies  >3 publications with Grb14 and Embryonic Tissue
 Lung Antibodies  >2 publications with Grb14 and Lung
 Testis Antibodies  >1 publications with Grb14 and Testis
 Brain Antibodies  >1 publications with Grb14 and Brain
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000